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Failure to detect significant association between estrogen receptor-alpha gene polymorphisms and endometriosis in Japanese women

, 3Email author, Yukie Y. Kikuti1, Shun-ichiro Izumi2, Kenichi Goya2, Takahiro Suzuki2, Li-yi Cai2, Akira Oka1, Hidetoshi Inoko1, Jerzy K. Kulski1, 4 and Minoru Kimura1Email author Environmental Health

Failure to detect significant association between estrogen receptor-alpha gene polymorphisms and endometriosis in Japanese women

ObjectivesThe aim of the study was to test whether estrogen receptor 1 (ESR1) gene polymorphisms are correlated with the risk of the development of endometriosis in Japanese women, as a preliminary study.MethodsTo compare allelic frequencies and genotype distributions, a case-control study of 100 affected women and 143 women with no evidence of disease was performed using 10...

Geochemistry of soil gas in the seismic fault zone produced by the Wenchuan Ms 8.0 earthquake, southwestern China

The spatio-temporal variations of soil gas in the seismic fault zone produced by the 12 May 2008 Wenchuan Ms 8.0 earthquake were investigated based on the field measurements of soil gas concentrations after the main shock. Concentrations of He, H2, CO2, CH4, O2, N2, Rn, and Hg in soil gas were measured in the field at eight short profiles across the seismic rupture zone in June...

High-Mg Adakite and Low-Ca Boninite from a Bonin Fore-arc Seamount: Implications for the Reaction between Slab Melts and Depleted Mantle

Initial subduction-related boninitic magmatism occurred between 48 and 44 Ma in the Izu–Bonin–Mariana (IBM) arc. High-Mg adakites and low-Ca boninites have been dredged from the Bonin Ridge fore-arc seamount. Whole-rock 40Ar/ 39Ar ages suggest that the boninite (44·0 ± 1·4 Ma) and adakite (43·1 ± 1·0 and 40·8 ± 0·8 Ma) magmatism overlapped, or that the adakite magmatism occurred...

High-Throughput Sequencing Reveals the Gut Microbiome of the Bactrian Camel in Different Ages

The complex gut microbiota plays a key role in host metabolism and health. However, the core microbial communities in the different aged Bactrian camels remain totally unclear. We used high-throughput 16S rRNA gene sequencing to examine the temporal variability of the fecal microbiota in Bactrian camels. At 2 months of age, the fecal microbiota was composed of Firmicutes...

High-level expression of human arginase I in Pichia pastoris and its immobilization on chitosan to produce L-ornithine

Background L-ornithine (L-Orn), is an intermediate metabolite in the urea cycle that plays a significant role in humans. L-Orn can be obtained from the catalysis of L-arginine (L-Arg) by arginase. The Pichia pastoris expression system offers the possibility of generating a large amount of recombinant protein. The immobilized enzyme technology can overcome the difficulties in...

Hydrochemistry of the Hot Springs in Western Sichuan Province Related to the Wenchuan 8.0 Earthquake

Hydrogeochemistry of 32 hot springs in the western Sichuan Province after the Wenchuan 8.0 earthquake was investigated by analyzing the concentrations of cation and anion and the isotopic compositions of hydrogen and oxygen. The water samples of the hot springs were collected four times from June 2008 to April 2010. Hydrogeochemical data indicated the water samples can be...

IKKα contributes to UVB-induced VEGF expression by regulating AP-1 transactivation

Exposure to ultraviolet B (UVB) irradiation from sunlight induces the upregulation of VEGF, a potent angiogenic factor that is critical for mediating angiogenesis-associated photodamage. However, the molecular mechanisms related to UVB-induced VEGF expression have not been fully defined. Here, we demonstrate that one of the catalytic subunits of the IκB kinase complex (IKK), IKK...

IL-6-induced DNMT1 activity mediates SOCS3 promoter hypermethylation in ulcerative colitis-related colorectal cancer

Ulcerative colitis (UC) is associated with a high risk of developing colorectal cancer (CRC). The mechanisms by which chronic inflammatory responses in the colon may promote CRC remain only partially understood, but may involve reduced negative regulation of interleukin (IL)-6 signaling towards signal transducer and activator of transcription 3 activation through the loss of...

Identification and characterization of a Streptococcus equi ssp. zooepidemicus immunogenic GroEL protein involved in biofilm formation

Streptococcus equi ssp. zooepidemicus (S. equi spp. zooepidemicus) is an opportunistic pathogen that causes major economic losses in the swine industry in China and is also a threat for human health. Biofilm formation by this bacterium has been previously reported. In this study, we used an immunoproteomic approach to search for immunogenic proteins expressed by biofilm-grown S...

Identification of a novel linear B-cell epitope using a monoclonal antibody against the carboxy terminus of the canine distemper virus nucleoprotein and sequence analysis of the identified epitope in different CDV isolates

The Nucleoprotein (NP) is the most abundant and highly immunogenic protein in canine distemper virus (CDV), playing an important role in CDV viral replication and assembly. In this study, a specific monoclonal antibody, named C8, was produced against the NP protein C terminal (amino acids 401–523). A linear N protein epitope was identified by subjecting a series of partially...

Identifying protein complex by integrating characteristic of core-attachment into dynamic PPI network

International Cooperation Project of Hubei Province (No. 2014BHE0017), and the National Key Research and Development Program of China (SQ2017YFSF090207). Author Contributions Conceptualization: Li Yi. Formal ... analysis: Li Yi. Investigation: Li Yi. Methodology: Li Yi. Funding acquisition: Xingpeng Jiang, Tingting He, Wei Xie, Po Hu, Xiaohua Hu. Project administration: Xianjun Shen, Xingpeng Jiang, Xiaohua Hu

Increased risk of cancer in chronic dialysis patients: a population-based cohort study in Taiwan

Background. An increased incidence of cancer in chronic dialysis patients has not been confirmed in the Chinese population. The aim of this population-based study was to examine the risk of various types of cancers in chronic dialysis patients in Taiwan.

Influence of defect density on the ZnO nanostructures of dye-sensitized solar cells

The relationship between bilayer nanostructure, defect density and dye-sensitized solar cell (DSCC) performances was investigated. By adjusting bilayer nanostructures, defect density of ZnO nanodendrite-nanorods structure was decreased comparing to that of nanoflower-nanorods structure. The performances of DSCC based on ZnO nanodendrites-nanorods structure and nanoflower-nanorods...

Inhibitory Effects of Vitamin A on TCDD-induced Cytochrome P-450 1A1 Enzyme Activity and Expression

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an extremely potent environmental contaminant that produces a wide range of adverse biological effects, including the induction of cytochrome P450 1A1(CYP1A1) that may enhance the toxic effects of TCDD. Several studies indicated that concurrent supplementation of vitamin A could reduce the toxicity, and potentially inhibit CYP1A1...

Insight into the specific virulence related genes and toxin-antitoxin virulent pathogenicity islands in swine streptococcosis pathogen Streptococcus equi ssp. zooepidemicus strain ATCC35246

Background Streptococcus equi ssp. zooepidemicus (S. zooepidemicus) is an important pathogen causing swine streptococcosis in China. Pathogenicity islands (PAIs) of S. zooepidemicus have been transferred among bacteria through horizontal gene transfer (HGT) and play important roles in the adaptation and increased virulence of S. zooepidemicus. The present study used comparative...

Interaction between M-Like Protein and Macrophage Thioredoxin Facilitates Antiphagocytosis for Streptococcus equi ssp. zooepidemicus

Streptococcus equi ssp. zooepidemicus (S. zooepidemicus, S.z) is one of the common pathogens that can cause septicemia, meningitis, and mammitis in domesticated species. M-like protein (SzP) is an important virulence factor of S. zooepidemicus and contributes to bacterial infection and antiphagocytosis. The interaction between SzP of S. zooepidemicus and porcine thioredoxin (TRX...

MMP7 expression regulated by endocrine therapy in ERβ-positive colon cancer cells

Background Many studies have shown that colon cancer is an estrogen-dependent carcinoma. This study explored the efficacy of endocrine therapy in colon cancer cells with high metastatic potential (HT29). We investigated the proliferation of HT29 cells after exposure to endocrine therapy (tamoxifen) and 5-FU. Methods Apoptosis was evaluated using flow cytometry. The expression of...

Mapping Brain Injury with Symmetrical-channels' EEG Signal Analysis – A Pilot Study

A technique for detecting brain injury at the bedside has great clinical value, but conventional imaging techniques (such as computed tomography [CT] and magnetic resonance imaging) are impractical. In this study, a novel method–the symmetrical channel electroencephalogram (EEG) signal analysis–was developed for this purpose. The study population consisted of 45 traumatic brain...