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Peripheral brain-derived neurotrophic factor in autism spectrum disorder: a systematic review and meta-analysis

Brain-derived neurotrophic factor (BDNF) regulates neuronal survival and growth and promotes synaptic plasticity. Recently, researchers have begun to explore the relationship between peripheral BDNF levels and autism spectrum disorder (ASD), but the findings are inconsistent. We undertook the first systematic review and meta-analysis of studies examining peripheral BDNF levels in...

To Unveil the Molecular Mechanisms of Qi and Blood through Systems Biology-Based Investigation into Si-Jun-Zi-Tang and Si-Wu-Tang formulae

Traditional Chinese Medicine (TCM) is increasingly getting clinical application worldwide. But its theory like QI-Blood is still abstract. Actually, Qi deficiency and blood deficiency, which were treated by Si-Jun-Zi-Tang (SJZT) and Si-Wu-Tang (SWT) respectively, have characteristic clinical manifestations. Here, we analyzed targets of the ingredients in SJZT and SWT to unveil...

Combined Impact of Known Lifestyle Factors on Total and Cause-Specific Mortality among Chinese Men: A Prospective Cohort Study

& Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200032, ChinaQing-Li Zhang, Long-Gang Zhao, Wei Zhang, Hong-Lan Li, Jing Gao ... , USAWei Zheng & Xiao-Ou Shu AuthorsSearch for Qing-Li Zhang in:Nature Research journals • PubMed • Google Scholar Search for Long-Gang Zhao in:Nature Research journals • PubMed • Google Scholar Search for

Fabrication and Manipulation of Ciliary Microrobots with Non-reciprocal Magnetic Actuation

Non- reciprocal Magnetic Actuation Sangwon Kim Seungmin Lee Jeonghun Lee Bradley J. Nelson Li Zhang Hongsoo Choi OPEN Magnetically actuated ciliary microrobots were designed, fabricated, and

A novel chalcone derivative S17 induces apoptosis through ROS dependent DR5 up-regulation in gastric cancer cells

A new series of etherification chalcone derivatives were designed and synthesized through Willimison etherification and Claisen-Schmidt condensation. Among them, compound 2-c which was given chemical name of S17, has been successfully screened out as the most potent one on gastric cancer cell line(MGC803) through the investigation for their effects against the growth of five...

Electrophysiological evidences demonstrating differences in brain functions between nonmusicians and musicians

Li Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Weiwei Peng in:Nature Research journals • PubMed • Google ScholarSearch for Jie Chen in:Nature Research journals • PubMed

Cerebrospinal Fluid IL-10 and IL-10/IL-6 as Accurate Diagnostic Biomarkers for Primary Central Nervous System Large B-cell Lymphoma

Early diagnosis of primary central nervous system lymphoma (PCNSL) represents a challenge, and cerebrospinal fluid (CSF) cytokines may be diagnostic biomarkers for PCNSL. We used an electrochemiluminescence immunoassay to measure interleukin (IL)-10, IL-6, IL-8 and tumor necrosis factor α (TNF-α) in the CSF of 22 B cell PCNSL patients and 80 patients with other CNS diseases. CSF...

Calcium sensing receptor protects high glucose-induced energy metabolism disorder via blocking gp78-ubiquitin proteasome pathway

Hongzhu Li Li Zhang Yajun Zhao Bo Wu Ye Tian Weihua Zhang Lingyun Wu Rui Wang Changqing Xu Diabetic cardiomyopathy (DCM) is a major complication and fatal cause of the patients with diabetes. The calcium

Partial Oxidized Arsenene: Emerging Tunable Direct Bandgap Semiconductor

Arsenene, as a member of the Group V elemental two-dimensional materials appears on the horizon, has shown great prospects. However, its indirect bandgap limits the applications in optoelectronics. In this theoretical work, we reported that partial oxidation can tune the indirect bandgap of arsenene into the direct one. Attributed to the enthalpy decreasing linear to the oxygen...

Electrically driven single-photon emission from an isolated single molecule

Strategic Priority Research Program of the Chinese Academy of Sciences. Author information Author notes Li Zhang and Yun-Jie Yu contributed equally to this work. AffiliationsHefei National Laboratory for ... , Liu-Guo Chen, Yang Luo, Ben Yang, Fan-Fang Kong, Gong Chen, Yang Zhang, Qiang Zhang, Yi Luo, Jin-Long Yang, Zhen-Chao Dong & J. G. Hou AuthorsSearch for Li Zhang in:Nature Research journals • PubMed

Precise Photodynamic Therapy of Cancer via Subcellular Dynamic Tracing of Dual-loaded Upconversion Nanophotosensitizers

, Changchun, Jilin, ChinaYulei Chang, Xiaodan Li, Li Zhang, Lu Xia, Xiaomin Liu, Cuixia Li, Youlin Zhang, Langping Tu, Bin Xue & Xianggui KongThe First Hospital of Jilin University, Changchun 130021 ... , ChinaXiaodan Li, Li Zhang & Huiying ZhaoVan’t Hoff Institute for Molecular Sciences, University of Amsterdam Science Park 904, 1098 XH Amsterdam, The NetherlandsLangping Tu, Bin Xue & Hong Zhang AuthorsSearch

Whole Genome Sequencing Identifies Novel Compound Heterozygous Lysosomal Trafficking Regulator Gene Mutations Associated with Autosomal Recessive Chediak-Higashi Syndrome

Study Design: Zigang Xu, Tieliu Shi, and Yongli Guo. Conducted experiments: Yaqiong Jin, Li Zhang, Senfen Wang, Feng Chen, Yang Gu, Enyu Hong and Yongbo Yu. Performed data analysis: Li Zhang, Yaqiong Jin ... , Yongli Guo and Tieliu Shi. Wrote or contributed to the writing of the manuscript: Yaqiong Jin, Yongli Guo, Li Zhang, Senfen Wang, Feng Chen, Zigang Xu and Tieliu Shi. Project principal: Xin Ni, Tieliu Shi

Ultrabroadband Design for Linear Polarization Conversion and Asymmetric Transmission Crossing X- and K- Band

In this work, a high-efficiency and broadband reflective converter using ultrathin planar metamaterial (MM) composed of single-layered SRR is firstly realized. Numerical and experimental results demonstrate that the cross-polarization conversion reflectance above 0.84 is achieved from 8.6 to 18.6 GHz for linearly polarized (LP) incident waves under normal incidence. Subsequently...

Magnetically modulated critical current densities of Co/Nb hybrid

• Google ScholarSearch for Weike Wang in:Nature Research journals • PubMed • Google ScholarSearch for Li Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Zhaorong Yang in:Nature Research

Cytoplasmic Determination of Meiotic Spindle Size Revealed by a Unique Inter-Species Germinal Vesicle Transfer Model

Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, ChinaZhong-Wei Wang, Guang-Li Zhang & Qing-Yuan SunDepartment of Veterinary Pathobiology, University of ... Research journals • PubMed • Google ScholarSearch for Guang-Li Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Heide Schatten in:Nature Research journals • PubMed • Google ScholarSearch

Cyclooxygenase-2 induced β1-integrin expression in NSCLC and promoted cell invasion via the EP1/MAPK/E2F-1/FoxC2 signal pathway

Cyclooxygenase-2 (COX-2) has been implicated in cell invasion in non-small-cell lung cancer (NSCLC). However, the mechanism is unclear. The present study investigated the effect of COX-2 on β1-integrin expression and cell invasion in NSCLC. COX-2 and β1-integrin were co-expressed in NSCLC tissues. COX-2 overexpression or Prostaglandin E2 (PGE2) treatment increased β1-integrin...

Efficacy and safety of acupuncture in children: an overview of systematic reviews

Chunsong Yang in:Nature Research journals • PubMed • Google ScholarSearch for Zilong Hao in:Nature Research journals • PubMed • Google ScholarSearch for Ling-Li Zhang in:Nature Research journals • PubMed ... • Google ScholarSearch for Qin Guo in:Nature Research journals • PubMed • Google Scholar Corresponding author Correspondence to Ling-Li Zhang. Rights and permissions To obtain permission to re-use

Accelerating Gas Adsorption on 3D Percolating Carbon Nanotubes

, ChinaHui Li, Chenyu Wen, Youwei Zhang, Dongping Wu & Zhi-Jun QiuSolid-State Electronics, The Ångström Laboratory, Uppsala University, Uppsala Box 534, SE-751 21, SwedenShi-Li Zhang AuthorsSearch for Hui Li ... ScholarSearch for Dongping Wu in:Nature Research journals • PubMed • Google ScholarSearch for Shi-Li Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Zhi-Jun Qiu in:Nature Research journals

Needle-array to Plate DBD Plasma Using Sine AC and Nanosecond Pulse Excitations for Purpose of Improving Indoor Air Quality

RepoRts | Needle-array to plate DBD plasma Using sine AC and Nanosecond pulse excitations for purpose of Improving Indoor Air Quality Li Zhang DezhengYang Wenchun Wang sen Wang Hao Yuan Zilu Zhao

Prevalence and correlates of valvular heart diseases in the elderly population in Hubei, China

We sought to determine the prevalence and correlates of valvular heart diseases (VHD) in the elderly population. The participants’ personal information, medical history, behavioral habits and clinical status were assessed by questionnaire, while the left ventricular dimensions, function and the presence and severity of VHD were evaluated by transthoracic echocardiography. This...