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AUCpreD: proteome-level protein disorder prediction by AUC-maximized deep convolutional neural fields

Motivation: Protein intrinsically disordered regions (IDRs) play an important role in many biological processes. Two key properties of IDRs are (i) the occurrence is proteome-wide and (ii) the ratio of disordered residues is about 6%, which makes it challenging to accurately predict IDRs. Most IDR prediction methods use sequence profile to improve accuracy, which prevents its...

Surveillance of Live Poultry Markets for Low Pathogenic Avian Influenza Viruses in Guangxi Province, Southern China, from 2012–2015

Institute, 51 You Ai North Road, Nanning, Guangxi, 530001, ChinaSisi Luo, Zhixun Xie, Zhiqin Xie, Liji Xie, Li Huang, Jiaoling Huang, Xianwen Deng, Tingting Zeng, Sheng Wang, Yanfang Zhang & Jiabo Liu ... Scholar Search for Sheng Wang in:Nature Research journals • PubMed • Google Scholar Search for Yanfang Zhang in:Nature Research journals • PubMed • Google Scholar Search for Jiabo Liu in:Nature Research

Advances on the Use of Biodegradable Proteins/Peptides in Photothermal Theranostics

Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China Received 11 April 2016; Accepted 14 June 2016 Academic Editor: Muhamamd A. Malik Copyright © 2016 Sheng Wang et al. This is an open

Impact of severe left ventricular dysfunction on in-hospital and mid-term outcomes of Chinese patients undergoing first isolated off-pump coronary artery bypass grafting

Few studies focused on evaluating the impacts of preoperative severe left ventricular dysfunction on clinical outcomes of patients undergoing off-pump coronary artery bypass grafting surgery (OPCAB). This single center retrospective study aimed to evaluate the impacts of severe left ventricular dysfunction on in-hospital and mid-term clinical outcomes of Chinese patients...

Physiological and genomic features of a novel violacein-producing bacterium isolated from surface seawater

Strains JW1T and JW3, isolated from surface seawater of the Arabian Sea, were subjected to polyphasic taxonomic analysis. Cells of both strains were Gram-stain-negative, aerobic, and rod-shaped. They formed violet pigment and produced violacein. On the basis of 16S rRNA gene sequence analysis, strains JW1T and JW3 showed high 16S rRNA gene sequence similarity with...

Arabidopsis ubiquitin-conjugating enzyme UBC22 is required for female gametophyte development and likely involved in Lys11-linked ubiquitination

Protein ubiquitination is critical for numerous processes in eukaryotes. The ubiquitin-conjugating enzyme (E2) is required for ubiquitination. The Arabidopsis genome has approximately 37 E2 genes, but in vivo functions for most of them remain unknown. In this study we observed that knockout mutants of Arabidopsis UBC22 had much-reduced silique length and seed number, with nearly...

Complete genome sequence of bacteriochlorophyll-synthesizing bacterium Porphyrobacter neustonensis DSM 9434

The genus Porphyrobacter belongs to aerobic anoxygenic phototrophic bacteria cluster. Porphyrobacter neustonensis DSM 9434 was isolated from a eutrophic freshwater pond in Australia, and is able to synthesize Bacteriochlorophyll a as well as grow under aerobic conditions. It is the type species of the genus Porphyrobacter. Here we describe the characteristics of the strain DSM...

Self-Powered Active Sensor with Concentric Topography of Piezoelectric Fibers

In this study, we demonstrated a flexible and self-powered sensor based on piezoelectric fibers in the diameter range of nano- and micro-scales. Our work is distinctively different from previous electrospinning research; we fabricated this apparatus precisely via near-field electrospinning which has a spectacular performance to harvest mechanical deformation in arbitrary...

RaptorX-Property: a web server for protein structure property prediction

RaptorX Property ( is a web server predicting structure property of a protein sequence without using any templates. It outperforms other servers, especially for proteins without close homologs in PDB or with very sparse sequence profile (i.e. carries little evolutionary information). This server employs a powerful in...

Effect of testosterone on the Connexin37 of sexual mature mouse cumulus oocyte complex

Background Recent researches demonstrate that pre-treatment with androgen could increase retrieved oocytes number and clinical pregnancy rate in poor ovarian response (POR) patients. In view of gap junction intercellular communication (GJIC) is important for follicular growth, and androgen plays an important role in improving prognosis of POR patients, we speculate that androgen...

Susceptibility of influenza A(H1N1)/pdm2009, seasonal A(H3N2) and B viruses to Oseltamivir in Guangdong, China between 2009 and 2014

, ShengWang. Contributed reagents/materials/ analysis tools: Ping Xiong, Chang-wen Ke, Sheng Wang. Wrote the paper: Ping Xiong. Revised the paper: Ping Xiong, Chang-wen Ke, Sheng Wang, Ling-zhi Jiang. Wen-zhe

Adjuvant radiotherapy improves cause specific survival in stage II, not stage III mucinous carcinoma of the rectum

Background The effect of adjuvant radiotherapy on the survival outcomes of patients with mucinous rectal cancer remains unclear. This study evaluated the 5-year cause specific survival (CSS) of patients with mucinous rectal cancer after surgery to determine whether adjuvant radiotherapy conferred a survival benefit. Methods An analysis of the Surveillance, Epidemiology, and End...

Feed-Forward Neural Network Soft-Sensor Modeling of Flotation Process Based on Particle Swarm Optimization and Gravitational Search Algorithm

-Sheng Wang and Shuang Han. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided ... . Authors’ Contribution Jie-Sheng Wang participated in the concept, design, and interpretation and commented on the paper. Shuang Han participated in the data collection, analysis, algorithm simulation, the

Internal mammary sentinel lymph node biopsy: abandon or persist?

Internal mammary sentinel lymph node biopsy: abandon or persist? Peng-Fei Qiu, Yan-Bing Liu, Yong-Sheng Wang Breast Cancer Center, Shandong Cancer Hospital and Institute, Jinan, Shandong, People’s

Hybrid Multiple Soft-Sensor Models of Grinding Granularity Based on Cuckoo Searching Algorithm and Hysteresis Switching Strategy

Liaoning, Anshan 114044, China Received 21 July 2015; Revised 25 November 2015; Accepted 25 November 2015 Academic Editor: Frédéric Lardeux Copyright © 2015 Jie-Sheng Wang and Na-Na Shen. This is an open

SNAI1, an endothelial–mesenchymal transition transcription factor, promotes the early phase of ocular neovascularization

Ocular neovascularization is a comprehensive process involved in retinal vascular development and several blinding diseases such as age-related macular degeneration and retinopathy of prematurity, with vascular endothelial growth factor (VEGF) regarded as the master regulator. However, the qualified effect of anti-VEGF therapy reveals that the underlying mechanisms are still not...

Fluorescence and Magnetic Resonance Dual-Modality Imaging-Guided Photothermal and Photodynamic Dual-Therapy with Magnetic Porphyrin-Metal Organic Framework Nanocomposites

Phototherapy shows some unique advantages in clinical application, such as remote controllability, improved selectivity, and low bio-toxicity, than chemotherapy. In order to improve the safety and therapeutic efficacy, imaging-guided therapy seems particularly important because it integrates visible information to speculate the distribution and metabolism of the probe. Here we...

CoinFold: a web server for protein contact prediction and contact-assisted protein folding

CoinFold ( is a web server for protein contact prediction and contact-assisted de novo structure prediction. CoinFold predicts contacts by integrating joint multi-family evolutionary coupling (EC) analysis and supervised machine learning. This joint EC analysis is unique in that it not only uses residue coevolution information in the...