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The Study on In-City Capacity Affected by Pedestrian Crossing

Currently, the urban road traffic congestion is serious and the traffic accident is happening at a high frequency; thus it has not satisfied the travel needs of security and affects the quality of urban trips. In order to effectively relieve the confliction of people and motor vehicle, to make sure of the safety of pedestrians crossing the road, and to improve the capacity of...

The Study on In-City Capacity Affected by Pedestrian Crossing

Currently, the urban road traffic congestion is serious and the traffic accident is happening at a high frequency; thus it has not satisfied the travel needs of security and affects the quality of urban trips. In order to effectively relieve the confliction of people and motor vehicle, to make sure of the safety of pedestrians crossing the road, and to improve the capacity of...

Bee Inspired Novel Optimization Algorithm and Mathematical Model for Effective and Efficient Route Planning in Railway System

Railway and metro transport systems (RS) are becoming one of the popular choices of transportation among people, especially those who live in urban cities. Urbanization and increasing population due to rapid development of economy in many cities are leading to a bigger demand for urban rail transit. Despite being a popular variant of Traveling Salesman Problem (TSP), it appears...

Impact of Participation in the Adalimumab (Humira) Patient Support Program on Rheumatoid Arthritis Treatment Course: Results from the PASSION Study

. Jasmina Kalabic is an employee of AbbVie and may hold stock or options. Chen Wang is an employee of AbbVie and may hold stock or options. Naijun Chen is an employee of AbbVie and may hold stock or options

Model Development for Risk Assessment of Driving on Freeway under Rainy Weather Conditions

additional informed consent was required. In addition, Dr. Xiaonan Cai and other researchers in Transportation Research Center including Chen Wang, and Jian Lu administered this questionnaire. Moreover, the

Bedding down new words: Sleep promotes the emergence of lexical competition in visual word recognition

Lexical competition processes are widely viewed as the hallmark of visual word recognition, but little is known about the factors that promote their emergence. This study examined for the first time whether sleep may play a role in inducing these effects. A group of 27 participants learned novel written words, such as banara, at 8 am and were tested on their learning at 8 pm the...

Cuprous oxide nanoparticle-inhibited melanoma progress by targeting melanoma stem cells

Cuprous oxide nanoparticle-inhibited melanoma progress by targeting melanoma stem cells Bin Yu,1,2,* Ye Wang,3,* Xinlu Yu,1,* Hongxia Zhang,1 Ji Zhu,4 Chen Wang,1 Fei Chen,1 Changcheng Liu,1

PAK1 confers chemoresistance and poor outcome in non-small cell lung cancer via β-catenin-mediated stemness

Chen AuthorsSearch for Ming-Jenn Chen in:Nature Research journals • PubMed • Google ScholarSearch for De-Wei Wu in:Nature Research journals • PubMed • Google ScholarSearch for Yao-Chen Wang in:Nature

Nonequilibrium Energy Transfer at Nanoscale: A Unified Theory from Weak to Strong Coupling

Science and Engineering, Tongji University, 200092 Shanghai, P. R. ChinaJie Ren AuthorsSearch for Chen Wang in:Nature Research journals • PubMed • Google ScholarSearch for Jie Ren in:Nature Research

Drug discovery using clinical outcome-based Connectivity Mapping: application to ovarian cancer

Background Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer death among women in the United States (5 % of cancer deaths). The standard treatment for patients with advanced EOC is initial debulking surgery followed by carboplatin-paclitaxel combination chemotherapy. Unfortunately, with chemotherapy most patients relapse and die resulting in a five-year overall...

Characterization of eleven monosomic alien addition lines added from Gossypium anomalum to Gossypium hirsutum using improved GISH and SSR markers

Background Gossypium anomalum (BB genome) possesses the desirable characteristics of drought tolerance, resistance to diseases and insect pests, and the potential for high quality fibers. However, it is difficult to transfer the genes associated with these desirable traits into cultivated cotton (G. hirsutum, AADD genome). Monosomic alien addition lines (MAALs) can be used as a...

Positive Correlation between Enhanced Expression of TLR4/MyD88/NF-κB with Insulin Resistance in Placentae of Gestational Diabetes Mellitus

Insulin resistance (IR) is a critical factor of the pathophysiology of Gestational diabetes mellitus (GDM). Studies on key organs involved in IR, such as livers and adipose tissues, showed that Toll-like receptor 4 (TLR4) can regulate insulin sensitivity. As a maternal-fetal interface with multi-functions, placentae could contribute to the development of IR for GDM. Thus, we...

Smoking cessation in Asians: focus on varenicline

Smoking cessation in Asians: focus on varenicline Dan Xiao,* Shuilian Chu,* Chen Wang Clinical Cessation and Tobacco Medicine Research Centre, China-Japan Friendship Hospital, Beijing, People’s ... covered by medical insurance in most Asian countries. Disclosure Chen Wang and Dan Xiao have consulted for a number of companies with an interest in clinical trials of medication and medical professionals

Improvement of sexual function in POEMS syndrome after combination therapy of Lenalidomide and dexamethasone

Background POEMS syndrome is a rare paraneoplastic syndrome due to an underlying plasma cell neoplasm. Hypogonadism is the most common endocrine abnormality in POEMS syndrome. There is no data about improvement of hypogonadism and sexual dysfunction after appropriate treatment of POEMS syndrome so far. In this single-center prospective study, the efficacy of low-dose lenalidomide...

Phylogenetic Analyses of Armillaria Reveal at Least 15 Phylogenetic Lineages in China, Seven of Which Are Associated with Cultivated Gastrodia elata

Fungal species of Armillaria, which can act as plant pathogens and/or symbionts of the Chinese traditional medicinal herb Gastrodia elata (“Tianma”), are ecologically and economically important and have consequently attracted the attention of mycologists. However, their taxonomy has been highly dependent on morphological characterization and mating tests. In this study, we...

Improving E-Bike Safety on Urban Highways in China

This paper aims to examine characteristics of e-bike fatal crashes on urban highways in China. Crash data were retrieved from the three-year crash reports (2010–2012) of Taixing City. Descriptive analysis was conducted to examine characteristics of e-bike riders, drivers, and crashes. The important findings include the following: (1) most fatal crashes were related to e-bike...

Comparative analysis of volatiles difference of Yunnan sun-dried Pu-erh green tea from different tea mountains: Jingmai and Wuliang mountain by chemical fingerprint similarity combined with principal component analysis and cluster analysis

Background Modern instrumental analysis technology can provide various chemical data and information on tea samples. Unfortunately, it remains difficult to extract the useful information. We describe the use of chemical fingerprint similarities, combined with principal component and cluster analyses, to distinguish and recognize Pu-erh green teas, which from two tea mountains...

MiR-26 enhances chemosensitivity and promotes apoptosis of hepatocellular carcinoma cells through inhibiting autophagy

Hongwei Liang Chen Wang Feng Wang Chen-Yu Zhang Ke Zen Limin Li Hepatocellular carcinoma (HCC) generally possesses a high resistance to chemotherapy. Given that autophagy is an important factor promoting

Identification of downstream target genes regulated by the nitric oxide–soluble guanylate cyclase–cyclic guanosine monophosphate signal pathway in pulmonary hypertension

Objective To investigate the downstream target genes regulated by the nitric oxide–soluble guanylate cyclase–cyclic guanosine monophosphate (NO-sGC-cGMP) signal pathway and their possible roles in the pathogenesis of pulmonary hypertension (PH).