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LncRNA-AF113014 promotes the expression of Egr2 by interaction with miR-20a to inhibit proliferation of hepatocellular carcinoma cells

Long non-coding RNAs (lncRNAs), tentatively identified as non-protein coding RNA, are transcripts more than 200nt in length and accounting for 98% of the whole genome of human being. Accumulating evidence showed aberrant expressions of lncRNAs are strongly correlated to the development of cancers. In this study, AF113014 is a new lncRNA identified from Microarray. We found...

AAgAtlas 1.0: a human autoantigen database

Autoantibodies refer to antibodies that target self-antigens, which can play pivotal roles in maintaining homeostasis, distinguishing normal from tumor tissue and trigger autoimmune diseases. In the last three decades, tremendous efforts have been devoted to elucidate the generation, evolution and functions of autoantibodies, as well as their target autoantigens. However, reports...

Genome-wide identification of the Jatropha curcas MYB family and functional analysis of the abiotic stress responsive gene JcMYB2

Background The MYB family is one of the most abundant transcription factor families in plants. MYB proteins are involved in plant development, abiotic stress tolerance, hormone signal transduction and disease resistance. Here we perform genome-wide identification of MYB family transcription factors in an energy plant J. curcas, including determining family composition...

Kangfuxinye Enema Combined with Mesalamine for Ulcerative Colitis: A Systematic Review and GRADE Approach

’ Contributions Guarantor of the article is De-ying Kang. De-ying Kang conceived and designed the review. Peng-wei Ren, Wen-jie Yang, Jing-yan Shan, and Dan-dan Wang conducted literature searches, selected studies ... , assessed risk of bias, and extracted data. Peng-wei Ren, Wen-jie Yang, and Dan-dan Wang carried out analysis, applied GRADE, and interpreted results. Peng-wei Ren, De-ying Kang, and Qi Hong drafted the

Reduction of selenite to Se(0) nanoparticles by filamentous bacterium Streptomyces sp. ES2-5 isolated from a selenium mining soil

Wang 0 Gejiao Wang 0 Shixue Zheng 0 0 State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University , Wuhan 430070 , People's Republic of

Disrupting ROS-protection mechanism allows hydrogen peroxide to accumulate and oxidize Sb(III) to Sb(V) in Pseudomonas stutzeri TS44

Background Microbial antimonite [Sb(III)] oxidation converts toxic Sb(III) into less toxic antimonate [Sb(V)] and plays an important role in the biogeochemical Sb cycle. Currently, little is known about the mechanisms underlying bacterial Sb(III) resistance and oxidation. Results In this study, Tn5 transposon mutagenesis was conducted in the Sb(III)-oxidizing strain Pseudomonas...

Performance Gains in Genome-Wide Association Studies for Longitudinal Traits via Modeling Time-varied effects

Complex traits with multiple phenotypic values changing over time are called longitudinal traits. In traditional genome-wide association studies (GWAS) for longitudinal traits, a combined/averaged estimated breeding value (EBV) or deregressed proof (DRP) instead of multiple phenotypic measurements per se for each individual was frequently treated as response variable in...

Multivariate Time-Varying Copula GARCH Model and Its Application in the Financial Market Risk Measurement

Taking full advantage of the strengths of - distribution, Copula function, and GARCH model in depicting the return distribution of financial asset, we construct the multivariate time-varying - Copula GARCH model which can comprehensively describe “asymmetric, leptokurtic, and heavy-tail” characteristics, the time-varying volatility characteristics, and the extreme-tail dependence...

Multivariate Time-Varying Copula GARCH Model and Its Application in the Financial Market Risk Measurement

Taking full advantage of the strengths of - distribution, Copula function, and GARCH model in depicting the return distribution of financial asset, we construct the multivariate time-varying - Copula GARCH model which can comprehensively describe “asymmetric, leptokurtic, and heavy-tail” characteristics, the time-varying volatility characteristics, and the extreme-tail dependence...

Liposome bupivacaine for pain control after total knee arthroplasty: a meta-analysis

Background Total knee arthroplasty (TKA) is associated with intense and long-duration pain. Research is currently being conducted on the use of liposome bupivacaine (LB) to prolong the effects of local infiltration anesthesia. This systematic review and meta-analysis of randomized controlled trials (RCTs) evaluated the efficacy and safety of pain control of using LB versus...

Performance analysis of cooperative cognitive MIMO multiuser downlink transmission with perfect and imperfect CSI over Rayleigh fading channels

In this paper, a comprehensive comparison analysis in terms of outage probability and average symbol error ratio (SER) is presented for cooperative cognitive multiple-input and multiple-output (CC-MIMO) multiuser systems with amplify-and-forward (AF) protocol. Specially, we consider two scenarios where the CC-MIMO multiuser systems have the perfect and imperfect channel state...

Comparative epidemiology of porcine circovirus type 3 in pigs with different clinical presentations

Porcine circovirus type 3 (PCV3), as an emerging circovirus species, was reported to be widely circulating in the United States, China, South Korea and Poland. Previous studies revealed that PCV3 was mainly concentrated in sick animals with respiratory disease, skin disease, reproductive disorders and so on. However, the circulating status of PCV3 in pigs with other clinical...

Development and characterization of a novel luciferase based cytotoxicity assay

Gong, Saurabh D. Chitnis, Michael Kahn, Xu Han, Vishan Chaudhary, Adam Soni, Jennifer Sernas, Prottasha Khan, Dan Wang & Preet M. Chaudhary AuthorsSearch for Hittu Matta in:Nature Research journals ... Khan in:Nature Research journals • PubMed • Google Scholar Search for Dan Wang in:Nature Research journals • PubMed • Google Scholar Search for Preet M. Chaudhary in:Nature Research journals • PubMed

Magnetic and pH dual-responsive mesoporous silica nanocomposites for effective and low-toxic photodynamic therapy

Magnetic and pH dual-responsive mesoporous silica nanocomposites for effective and low-toxic photodynamic therapy Jieqiong Zhan,1,2,* Zhiqiang Ma,2,* Dan Wang,3 Xinfang Li,2 Xiangui Li,2 Lijing Le,2

Ginsenosides synergize with mitomycin C in combating human non-small cell lung cancer by repressing Rad51-mediated DNA repair

participated in research design; Min ZHAO, Dan-dan WANG, Yuan CHE, Qing-ran LI and Chang SHAO conducted experiments; Yuan CHE, Meng-qiu WU and Yun WANG contributed new reagents or analytical tools; Min ZHAO

Effectiveness of Traditional Chinese Medicine Compound JieDuTongLuoShengJin Granules Treatment in Primary Sjögren’s Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

 Jiaqi Hou,1 Yue Yang,1 Xuemei Piao,1 Yueying Chen,2 Luan Xue,1 Dan Wang,1 Jiandong Hu,1 Guoling Li,1 Xiangxiang Wu,1 Yu Sun,1 and Runa Jin3 1Department of Rheumatology and Immunology, Yueyang Hospital of

Gliomatosis peritonei: a series of eight cases and review of the literature

Background Gliomatosis peritonei (GP) is a rare condition characterized by mature glial tissue implants widespread in the peritoneum. The GP is often associated with ovarian teratoma. However, little is known about the characteristics and prognosis of GP. The purpose of this study was to describe the features, treatment, and prognosis of GP. Additionally, we review previously...

Malignancy risk stratification of thyroid nodules: comparisons of four ultrasound Thyroid Imaging Reporting and Data Systems in surgically resected nodules

, 200072, ChinaYing Wang, Ya-Ping He, Xiao-Long Li, Wei-Wei Ren, Chong-Ke Zhao, Xiao-Wan Bo, Dan Wang, Cheng-Yu Sun & Hui-Xiong XuDepartment of Medical Ultrasound, Yangpu Hospital, Tongji University School ... Zhao, Xiao-Wan Bo, Dan Wang, Cheng-Yu Sun & Hui-Xiong XuShanghai Center for Thyroid Diseases, Shanghai, 200072, ChinaYing Wang, Ya-Ping He, Xiao-Long Li, Wei-Wei Ren, Chong-Ke Zhao, Xiao-Wan Bo, Dan Wang

Risk factors for nosocomial nontraumatic coma: sepsis and respiratory failure

Risk factors for nosocomial nontraumatic coma: sepsis and respiratory failure Ye-Ting Zhou,1,2 Shao-Dan Wang,3 Guang-Sheng Wang,4 Xiao-Dong Chen,4 Dao-Ming Tong4 1Department of Clinical Research

Jin Fu Kang Oral Liquid Inhibits Lymphatic Endothelial Cells Formation and Migration

Lung cancer is the leading cause of cancer-related deaths worldwide. Jin Fu Kang (JFK), an oral liquid prescription of Chinese herbal drugs, has been clinically available for the treatment of non-small cell lung cancer (NSCLC). Lymphangiogenesis is a primary event in the process of cancer development and metastasis, and the formation and migration of lymphatic endothelial cells...