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Qualitative and Quantitative Characterization of Monosaccharide Components of Salvia miltiorrhiza, Liguspyragine Hydrochloride, and Glucose Injection

 Chang-qiong Bi,3 Tian-ling Chen,2,4 Xiang-dong Zhang,1,2 and Xue Xiao2,4 1School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China 2Nansha Research Institute, Sun Yat-sen

The prognostic significance of DAPK1 in bladder cancer

Bladder cancer is one of the leading causes of cancer-related death in men, however, there was only limited effective treatment for invasive bladder cancer. DAPK1 has been shown to play important role in apoptosis and autophagy to suppress cancer progression. Previous results have shown that DAPK1 promoter was hypermethylated in the majority of bladder cancer specimens, however...

Phylogenetic reassessment of tribe Anemoneae (Ranunculaceae): Non-monophyly of Anemone s.l. revealed by plastid datasets

Morphological and molecular evidence strongly supported the monophyly of tribe Anemoneae DC.; however, phylogenetic relationships among genera of this tribe have still not been fully resolved. In this study, we sampled 120 specimens representing 82 taxa of tribe Anemoneae. One nuclear ribosomal internal transcribed spacer (nrITS) and six plastid markers (atpB-rbcL, matK, psbA...

Association between acute gastrointestinal injury and biomarkers of intestinal barrier function in critically ill patients

To assess the associations of biomarkers of intestinal barrier function and other clinical variables with acute gastrointestinal injury (AGI) grade, and of these clinical variables with mortality in critically ill patients. This was a single-center, observational, prospective study. Patients were included if they were diagnosed with AGI and underwent tests for the measurement of...

Glycopatterns of Urinary Protein as New Potential Diagnosis Indicators for Diabetic Nephropathy

, China 3Laboratory for Functional Glycomics, College of Life Sciences, Northwest University, Xi’an, China Correspondence should be addressed to Zheng Li; nc.ude.uwn@ilgnehz and Dong Zhang; moc.621

A comparative study of the characterization of miR-155 in knockout mice

miR-155 is one of the most important miRNAs and plays a very important role in numerous biological processes. However, few studies have characterized this miRNA in mice under normal physiological conditions. We aimed to characterize miR-155 in vivo by using a comparative analysis. In our study, we compared miR-155 knockout (KO) mice with C57BL/6 wild type (WT) mice in order to...

A network-based method for mechanistic investigation of Shexiang Baoxin Pill’s treatment of cardiovascular diseases

Liu Run-Hui Liu Wei-Dong Zhang wdzhangy@hotmail Jing Zhao OPEN Shexiang Baoxin Pill (SBP), a traditional Chinese medicine formula, is commonly used to treat cardiovascular disease (CVD) in China

Transcriptome analysis of bagging-treated red Chinese sand pear peels reveals light-responsive pathway functions in anthocyanin accumulation

• Google Scholar Search for Lin Li in:Nature Research journals • PubMed • Google Scholar Search for Qun Shu in:Nature Research journals • PubMed • Google Scholar Search for Dong Zhang in:Nature Research ... manuscript. All of the authors read and approved the final manuscript. Competing Interests The authors declare that they have no competing interests. Corresponding authors Correspondence to Dong Zhang or

Phase-specific expression of an insulin-like androgenic gland factor in a marine shrimp Lysmata wurdemanni: Implication for maintaining protandric simultaneous hermaphroditism

Background Shrimp in the genus Lysmata have a unique and rare sexual system referred to as protandric simultaneous hermaphroditism, whereby individuals mature first as male (male phase), and then the female function may also develop as the shrimp grow, so that the gonad is able to produce both eggs and sperms simultaneously, a condition called simultaneous hermaphroditism...

Up-regulation of CRKL by microRNA-335 methylation is associated with poor prognosis in gastric cancer

MicroRNAs have been suggested to play a vital role in regulating carcinogenesis, tumor progression and invasion. MiR-335 is involved in suppressing metastasis and invasion in various human cancers. However, the mechanisms responsible for the aberrant expression of miR-335 in gastric cancer (GC) remain unknown. Expression of miR-335 in four GC cell lines and 231 GC tissues was...

Rapamycin/sodium hyaluronate binding on nano-hydroxyapatite coated titanium surface improves MC3T3-E1 osteogenesis

Endosseous titanium (Ti) implant failure due to poor biocompatibility of implant surface remains a major problem for osseointegration. Improving the topography of Ti surface may enhance osseointegration, however, the mechanism remains unknown. To investigate the effect of modified Ti surface on osteogenesis, we loaded rapamycin (RA) onto nano-hydroxyapatite (HAp) coated Ti...

Integrated Analysis of LncRNA-mRNA Co-Expression Profiles in Patients with Moyamoya Disease

equally to this work. AffiliationsDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, ChinaWen Wang, Faliang Gao, Dong Zhang, Yan Zhang, Jiangfei Wang & Jizong ... , 100050, ChinaWen Wang, Faliang Gao, Dong Zhang, Yan Zhang, Jiangfei Wang & Jizong ZhaoBeijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, 100050, ChinaWen Wang, Faliang

Autophagy induced by DAMPs facilitates the inflammation response in lungs undergoing ischemia-reperfusion injury through promoting TRAF6 ubiquitination

Hao Cao Jian Li Bo Wang Peng Zhang Xu Dong Zhang Zhongmin Liu Hongbin Yuan Zhenzhen Zhan Lung ischemia-reperfusion (I/R) injury remains one of the most common complications after various

ZP3 is Required for Germinal Vesicle Breakdown in Mouse Oocyte Meiosis

-Lei Gao, Chun-Xiang Zhou, Xiao-Lan Zhang, Peng Liu, Zhen Jin, Gang-Yi Zhu, Yang Ma, Jing Li, Zhi-Xia Yang & Dong Zhang AuthorsSearch for Lei-Lei Gao in:Nature Research journals • PubMed • Google ... for Dong Zhang in:Nature Research journals • PubMed • Google Scholar Contributions D.Z., Z.-X.Y. and J.L. designed research; L.-L.G., and C.-X.Z. performed most of the experiments and data analysis; X

Kinematic space and wormholes

Abstract The kinematic space could play a key role in constructing the bulk geometry from dual CFT. In this paper, we study the kinematic space from geometric points of view, without resorting to differential entropy. We find that the kinematic space could be intrinsically defined in the embedding space. For each oriented geodesic in the Poincaré disk, there is a corresponding...

The status of diagnosis and treatment to intracranial hypotension, including SIH

Intracranial hypotension, especially spontaneous intracranial hypotension (SIH), is a well—recognized entity associated with cerebrospinal fluid (CSF) leaks, and has being recognized better in resent years, while still woefully inadequate. An increasing number of factors including iatrogenic factors are realized to involve in development and progression of intracranial...

MiR-1307 promotes ovarian cancer cell chemoresistance by targeting the ING5 expression

Background We aimed to investigate the function of miR-1307 in chemoresistance and to explore its chemoresistance mechanism in ovarian cancer. Methods IC50 determination was used to test the chemoresistance profling in ovarian cancer cells. QRT-PCR or western blot was used to validate the expression level of miR-1307 and candidate gene or protein. Colony formation assay and FITC...

Intratumoral and peritumoral lymphatic vessel density both correlate with lymph node metastasis in breast cancer

The status of lymph node involvement is an important prognostic factor for breast cancer. However, the presence of intratumoral lymphatic vessels in primary tumor lesions and the relationship between lymphatic vessel density (LVD) and lymph node metastasis (LNM) have not been firmly established. Therefore, we performed a meta-analysis study to investigate these issues. According...

Risk Factors for the Rupture of Middle Cerebral Artery Bifurcation Aneurysms Using CT Angiography

Background and Purpose To investigate the clinical and morphological characteristics associated with risk factors for the rupture of bifurcation-type middle cerebral artery aneurysms (MCAAs). Methods A total of 169 consecutive patients with 177 bifurcation-type MCAAs were reviewed from August 2011 to January 2016. Based on the clinical and morphologic characteristics findings...

Predicting missing links in complex networks based on common neighbors and distance

, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, P.R. ChinaJinxuan Yang & Xiao-Dong Zhang AuthorsSearch for Jinxuan Yang in:Nature Research journals • PubMed • Google ScholarSearch for ... Xiao-Dong Zhang in:Nature Research journals • PubMed • Google Scholar Contributions This manuscript was completed by J.-X. Yang and X.-D. Zhang. In the initial stage X.-D. Zhang provided many good ideas