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The Associations between Toll-Like Receptor 9 Gene Polymorphisms and Cervical Cancer Susceptibility

This meta-analysis systematically reviews the association between Toll-like receptor 9 polymorphisms and the risk of cervical cancer. Case-control studies focused on the association were collected from the PubMed, Web of Science, Cochrane Library, Embase, MEDLINE, CNKI, VIP, and Wanfang databases from inception to July 2017. We screened the studies and assessed the methodological...

Validity of parameter optimization in improving MJO simulation and prediction using the sub-seasonal to seasonal forecast model of Beijing Climate Center

Using the sub-seasonal to seasonal forecast model of Beijing Climate Center, several key physical parameters are perturbed by the Latin hypercube sampling method to find a better configuration for representation of Madden–Julian oscillation (MJO) in the free-run simulation. We find that although model simulation is especially sensitive to some parameters, there are overall no...

Computational Analysis of Artimisinin Derivatives on the Antitumor Activities

The study on antitumor activities of artemisinin and its derivatives has been closely focused on in recent years. Herein, 2D and 3D QSAR analysis was performed on the basis of a series of artemisinin derivatives with known bioactivities against the non-small-cell lung adenocarcinoma A549 cells. Four QSAR models were successfully established by CoMSIA, CoMFA, topomer CoMFA and...

Six-Point Subdivision Schemes with Cubic Precision

This paper presents 6-point subdivision schemes with cubic precision. We first derive a relation between the 4-point interpolatory subdivision and the quintic B-spline refinement. By using the relation, we further propose the counterparts of cubic and quintic B-spline refinements based on 6-point interpolatory subdivision schemes. It is proved that the new family of 6-point...

Fabrication of ultrasmall WS2 quantum dots-coated periodic mesoporous organosilica nanoparticles for intracellular drug delivery and synergistic chemo-photothermal therapy

Fabrication of ultrasmall WS2 quantum dots-coated periodic mesoporous organosilica nanoparticles for intracellular drug delivery and synergistic chemo-photothermal therapy Wenyun Liao,1 Li Zhang,1

First-line afatinib vs gefitinib for patients with EGFR mutation-positive NSCLC (LUX-Lung 7): impact of afatinib dose adjustment and analysis of mode of initial progression for patients who continued treatment beyond progression

PurposeIn the randomized phase IIb LUX-Lung 7 trial, afatinib significantly improved progression-free survival (PFS) and time-to-treatment failure vs gefitinib in patients with treatment-naïve epidermal growth factor receptor mutation-positive non-small cell lung cancer. We report post hoc analyses of tolerability-guided dose adjustment for afatinib and summarize the clinical...

A Facile Synthesis of Highly Nitrogen-Doped Carbon Dots for Imaging and Detection in Biological Samples

A facile, green, and high-output hydrothermal synthesis was proposed for the fabrication of highly fluorescent nitrogen-doped carbon quantum dots (N-doped CDs). The nitrogen content in N-doped CDs reached 19.2% and demonstrated strong blue fluorescence emission was obtained with fluorescence quantum yield (QY) of up to 32.9%, which exhibit high fluorescence quantum yield, high...

Prognostic impact of HbA1c variability on long-term outcomes in patients with heart failure and type 2 diabetes mellitus

The prognostic impact of long-term glycemic variability on clinical outcomes in patients with heart failure (HF) and type 2 diabetes mellitus (T2DM) remains unclear. We determined and compared hemoglobin A1c (HbA1c) variability and clinical outcomes for patients with HF with preserved ejection fraction (HFpEF), HF with mid-range ejection fraction (HFmrEF) and HF with reduced...

An Alternative Method for Long-Term Culture of Chicken Embryonic Stem Cell In Vitro

addressed to Hongbing Han; nc.ude.uac@gnibgnohnah Received 10 January 2018; Accepted 20 March 2018; Published 9 May 2018 Academic Editor: Cinzia Marchese Copyright © 2018 Li Zhang et al. This is an open ... corresponding author upon request. Conflicts of Interest The authors declare that they have no competing financial interests. Authors’ Contributions Li Zhang and Yenan Wu contributed equally to this work

An Alternative Method for Long-Term Culture of Chicken Embryonic Stem Cell In Vitro

addressed to Hongbing Han; nc.ude.uac@gnibgnohnah Received 10 January 2018; Accepted 20 March 2018; Published 9 May 2018 Academic Editor: Cinzia Marchese Copyright © 2018 Li Zhang et al. This is an open ... corresponding author upon request. Conflicts of Interest The authors declare that they have no competing financial interests. Authors’ Contributions Li Zhang and Yenan Wu contributed equally to this work

Perioperative diltiazem or nitroglycerin in on-pump coronary artery bypass: A systematic review and network meta-analysis

conducted, there is no institutional funding support for this study. (DOC) Author Contributions Conceptualization: Li Zhang, Xianren Wu, Xiaopeng Zhang. Data curation: Xinbei Yang, Xianren Wu, Anastasia ... Yian Liu, Xiaopeng Zhang. Formal analysis: Yirui Hu, Xiaopeng Zhang. Funding acquisition: H. Lester Kirchner, Xiaopeng Zhang. Investigation: Li Zhang, Xianren Wu, Joseph A. Boscarino, Alfred S. Casale

Interface-Dependent Effective Mobility in Graphene Field-Effect Transistors

By pretreating the substrate of a graphene field-effect transistor (G-FET), a stable unipolar transfer characteristic, instead of the typical V-shape ambipolar behavior, has been demonstrated. This behavior is achieved through functionalization of the SiO2/Si substrate that changes the SiO2 surface from hydrophilic to hydrophobic, in combination with postdeposition of an Al2O3...

External Electric Field Effect on Shallow Donor Impurity States in Zinc-Blende InxGa1−xN/GaN Symmetric Coupled Quantum Dots

Based on the effective-mass approximation and variational procedure, the ground-state donor binding energy in a cylindrical zinc-blende /GaN symmetric coupled quantum dots (SCQDs) is investigated in the presence of the external electric field. Numerical results show that the donor binding energy increases firstly until a maximum value, and then it begins to drop quickly in all...

External Electric Field Effect on Shallow Donor Impurity States in Zinc-Blende InxGa1−xN/GaN Symmetric Coupled Quantum Dots

Based on the effective-mass approximation and variational procedure, the ground-state donor binding energy in a cylindrical zinc-blende /GaN symmetric coupled quantum dots (SCQDs) is investigated in the presence of the external electric field. Numerical results show that the donor binding energy increases firstly until a maximum value, and then it begins to drop quickly in all...

Microstructure and mechanical properties of a hot-extruded Al-based composite reinforced with core–shell-structured Ti/Al3Ti

An Al-based composite reinforced with core–shell-structured Ti/Al3Ti was fabricated through a powder metallurgy route followed by hot extrusion and was found to exhibit promising mechanical properties. The ultimate tensile strength and elongation of the composite sintered at 620°C for 5 h and extruded at a mass ratio of 12.75:1 reached 304 MPa and 14%, respectively, and its...

Role of poly (ADP-ribose) polymerase-1 and cytokines in acute renal injury in elderly Chinese patients with diabetes mellitus

Role of poly (ADP-ribose) polymerase-1 and cytokines in acute renal injury in elderly Chinese patients with diabetes mellitus Li Cao, Yan Liu, Li Zhang, Yanfei Wei Intensive Medicine, Nanxishan

Characterizing dynamic behaviors of three-particle paramagnetic microswimmer near a solid surface

Particle-based magnetically actuated microswimmers have the potential to act as microrobotic tools for biomedical applications. In this paper, we report the dynamic behaviors of a three-particle paramagnetic microswimmer. Actuated by a rotating magnetic field with different frequencies, the microswimmer exhibits simple rotation and propulsion. When the input frequency is below 8...

Integrated analysis of hepatic mRNA and miRNA profiles identified molecular networks and potential biomarkers of NAFLD

Peiyong Zheng Li Zhang Guang Ji OPEN To enhance our understanding of molecular mechanisms and mine novel biomarkers of non-alcoholic fatty liver disease (NAFLD), RNA sequencing was performed to gain

Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model

Opioid analgesics are frequently prescribed in the United States and worldwide. However, serious comorbidities, such as dependence, tolerance, immunosuppression and gastrointestinal disorders limit their long-term use. In the current study, a morphine-murine model was used to investigate the role of the gut microbiome and metabolome as a potential mechanism contributing to the...

Design of Phase Gradient Coding Metasurfaces for Broadband Wave Modulating

Wave modulating is one of the most interesting applications of metasurfaces. It requires an effective method to design metasurfaces with arbitrary space-variant phase. In this paper, we proposed an optimized design method for arbitrarily modulating wave based on the Genetic Algorithm, which is efficient to optimize designated radiation patterns according to application...