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Sex-specific increase in susceptibility to metabolic syndrome in adult offspring after prenatal ethanol exposure with post-weaning high-fat diet

, Wuhan 430071, ChinaZheng He, Jing Li, Li Zhang & Hui WangDepartment of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, ChinaHanwen Luo & Liaobin ChenHubei Provincial Key ... ScholarSearch for Li Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Lu Ma in:Nature Research journals • PubMed • Google ScholarSearch for Liaobin Chen in:Nature Research journals • PubMed

Accurate Quantitative Sensing of Intracellular pH based on Self-ratiometric Upconversion Luminescent Nanoprobe

Accurate quantitation of intracellular pH (pHi) is of great importance in revealing the cellular activities and early warning of diseases. A series of fluorescence-based nano-bioprobes composed of different nanoparticles or/and dye pairs have already been developed for pHi sensing. Till now, biological auto-fluorescence background upon UV-Vis excitation and severe photo-bleaching...

The Chk1 inhibitor MK-8776 increases the radiosensitivity of human triple-negative breast cancer by inhibiting autophagy

MK-8776 is a recently described inhibitor that is highly selective for checkpoint kinase 1 (Chk1), which can weaken the DNA repair capacity in cancer cells to achieve chemo-sensitization. A number of studies show that MK-8776 enhances the cytotoxicity of hydroxyurea and gemcitabine without increasing normal tissue toxicities. Thus far, there is no evidence that MK-8776 can be...

Sub-nanometre control of the coherent interaction between a single molecule and a plasmonic nanocavity

Quantum Information and Quantum Physics, University of Science and Technology of China, Hefei 230026, ChinaYao Zhang, Qiu-Shi Meng, Li Zhang, Yang Luo, Yun-Jie Yu, Ben Yang, Yang Zhang, Yi Luo, Jin-Long ... Esteban AuthorsSearch for Yao Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Qiu-Shi Meng in:Nature Research journals • PubMed • Google ScholarSearch for Li Zhang in:Nature Research

ON and OFF retinal ganglion cells differentially regulate serotonergic and GABAergic activity in the dorsal raphe nucleus

The dorsal raphe nucleus (DRN), the major source of serotonergic input to the forebrain, receives excitatory input from the retina that can modulate serotonin levels and depressive-like behavior. In the Mongolian gerbil, retinal ganglion cells (RGCs) with alpha-like morphological and Y-like physiological properties innervate the DRN with ON DRN-projecting RGCs out numbering OFF...

USP16 Downregulation by Carboxyl-terminal Truncated HBx Promotes the Growth of Hepatocellular Carcinoma Cells

Hepatitis B virus (HBV) infection is a major factor that contributes to the development of hepatocellular carcinoma (HCC). HBV X protein (HBx) has been shown to accelerate HCC progression by promoting tumour growth and metastasis. In the clinic, carboxyl-terminal truncated HBx (Ct-HBx) proteins are frequently present in HCC tumour tissues, but not in non-tumorous tissues. In this...

MiR-152 suppresses the proliferation and invasion of NSCLC cells by inhibiting FGF2

journals • PubMed • Google ScholarSearch for Rongli Ma in:Nature Research journals • PubMed • Google ScholarSearch for Weijun Tan in:Nature Research journals • PubMed • Google ScholarSearch for Li Zhang

Efficacy-oriented compatibility for component-based Chinese medicine

Single-target drugs have not achieved satisfactory therapeutic effects for complex diseases involving multiple factors. Instead, innovations in recent drug research and development have revealed the emergence of compound drugs, such as cocktail therapies and “polypills”, as the frontier in new drug development. A traditional Chinese medicine (TCM) prescription that is usually...

Dietary, circulating beta-carotene and risk of all-cause mortality: a meta-analysis from prospective studies

applicable estimates. Data collection Two investigators (Long-Gang Zhao and Qing-Li Zhang) independently reviewed all available studies and extracted data with a standard collection form. Any discrepancies ... Disciplines and Specialties Foundation. Author information AffiliationsShanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaLong-Gang Zhao, Qing-Li Zhang

A versatile nanoplatform for synergistic combination therapy to treat human esophageal cancer

One of the major goals of precision oncology is to promote combination therapy to improve efficacy and reduce side effects of anti-cancer drugs based on their molecular mechanisms. In this study, we aimed to develop and validate new nanoformulations of docetaxel (DTX) and bortezomib (BTZ) for targeted combination therapy to treat human esophageal cancer. By leveraging our...

Maresin1 stimulates alveolar fluid clearance through the alveolar epithelial sodium channel Na,K-ATPase via the ALX/PI3K/Nedd4-2 pathway

of Wenzhou Medical University, Zhejiang, ChinaJun-Li Zhang, Xiao-Jun Zhuo, Jing Lin, Ling-Chun Luo, Wei-Yang Ying, Xiang Xie, Hua-Wei Zhang, Jing-Xiang Yang, Dan Li, Fang Gao Smith & Sheng-Wei ... JinAcademic Department of Anesthesia, Critical Care, Pain and Resuscitation, Birmingham Heartlands Hospital, Heart of England NHS Foundation Trust, Birmingham, UKFang Gao Smith AuthorsSearch for Jun-Li Zhang

Differential effects of gram-positive and gram-negative bacterial products on morphine induced inhibition of phagocytosis

in:Nature Research journals • PubMed • Google ScholarSearch for Li Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Anuj Saluja in:Nature Research journals • PubMed • Google ScholarSearch ... , Minneapolis, MN 55455Jana Ninkovic, Vidhu Anand, Raini Dutta, Anuj Saluja, Jingjing Meng, Lisa Koodie, Santanu Banerjee & Sabita RoyDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455.Li

Microwave ablation of hepatocellular carcinoma as first-line treatment: long term outcomes and prognostic factors in 221 patients

Ping Li Li Zhang Xiao-Yu Zhang Bo Zhai OPEN This retrospective study aimed at evaluating the long-term outcomes and prognostic factors of microwave ablation (MWA) as a first-line treatment for

Dual-functionalized liposomal delivery system for solid tumors based on RGD and a pH-responsive antimicrobial peptide

. AffiliationsKey Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern RenminRoad, Chengdu 610041, ChinaQianyu Zhang, Libao Lu, Li Zhang ... • PubMed • Google ScholarSearch for Li Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Kairong Shi in:Nature Research journals • PubMed • Google ScholarSearch for Xingli Cun in:Nature

Environmental spread of microbes impacts the development of metabolic phenotypes in mice transplanted with microbial communities from humans

University of Denmark, Lyngby, DenmarkLars I Hellgren AuthorsSearch for Li Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Martin Iain Bahl in:Nature Research journals • PubMed • Google

Chemical or genetic Pin1 inhibition exerts potent anticancer activity against hepatocellular carcinoma by blocking multiple cancer-driving pathways

Fujian Province Natural Science Fund for Distinguished Young Scientist (No. 2015J06017) and National Institutes of Health grant R01CA167677. Author information Author notesXin-Hua Liao, Arina Li Zhang ... , Fujian Medical University, Fuzhou, Fujian 350122, ChinaXin-Hua Liao, Arina Li Zhang, Min Zheng, Mei-Qing Li, Champ Peng Chen, Huijuan Xu, Qing-Song Chu, Dayun Yang, Wenxian Lu, Hekun Liu & Kun Ping LuKey

Expression of programmed death ligand-1 on tumor cells varies pre and post chemotherapy in non-small cell lung cancer

journals • PubMed • Google ScholarSearch for Hongyun Zhao in:Nature Research journals • PubMed • Google ScholarSearch for Li Zhang in:Nature Research journals • PubMed • Google Scholar Contributions Z.H.Y ... the manuscript and files. Competing interests The authors declare no competing financial interests. Corresponding author Correspondence to Li Zhang. Supplementary information PDF files1

Cholecystectomy is associated with higher risk of early recurrence and poorer survival after curative resection for early stage hepatocellular carcinoma

Although cholecystectomy has been reported to be associated with increased risk of developing hepatocellular carcinoma (HCC), the association between cholecystectomy and prognosis of HCC patients underwent curative resection has never been examined. Through retrospective analysis of the data of 3933 patients underwent curative resection for HCC, we found that cholecystectomy was...

Genome-wide detection of CNVs in Chinese indigenous sheep with different types of tails using ovine high-density 600K SNP arrays

Hongwei Wang Li Zhang Caihong Wei Qin Zhang Fuping Zhao Lixin Du OPEN Chinese indigenous sheep can be classified into three types based on tail morphology: fat-tailed, fatrumped, and thin-tailed sheep, of