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Identification of Mur34 as the Novel Negative Regulator Responsible for the Biosynthesis of Muraymycin in Streptomyces sp. NRRL30471

Background Muraymycin, a potent translocase I (MraY) inhibitor, is produced by Streptomyces sp. NRRL30471. The muraymycin gene cluster (mur) was recently cloned, and bioinformatic analysis of mur34 revealed its encoding product exhibits high homology to a large family of proteins, including KanI and RacI in individual biosynthetic pathway of kanamycin and ribostamycin. However...

Tumor Vascularity and Glucose Metabolism Correlated in Adenocarcinoma, but Not in Squamous Cell Carcinoma of the Lung

Background/Objectives To prospectively examine the relation between tumor vascularity and glucose metabolism in adenocarcinoma (AC) and squamous cell carcinoma(SCC) of the lung by using positron emission tomography/computed tomography (PET/CT) and dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). Materials and Methods Forty-one consecutive patients with...

Myeloid thrombomodulin lectin-like domain inhibits osteoclastogenesis and inflammatory bone loss

Ministry of Science and Technology (Taipei, Taiwan; grants NSC 102-2325-B-006-002- for Hua-Lin Wu, and MOST 104-2320-B-037-026 – for Tsung-Lin Cheng). This research was, in part, supported by the Ministry of ... These authors contributed equally to this work. AffiliationsDepartment of Physiology, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanTsung-Lin Cheng, Chau-Zen Wang & Mei-Ling

Microglia retard dengue virus-induced acute viral encephalitis

Patients with dengue virus (DENV) infection may also present acute viral encephalitis through an unknown mechanism. Here, we report that encephalitic DENV-infected mice exhibited progressive hunchback posture, limbic seizures, limbic weakness, paralysis, and lethality 7 days post-infection. These symptoms were accompanied by CNS inflammation, neurotoxicity, and blood-brain...

Toll-Like Receptor 4 Is Essential in the Development of Abdominal Aortic Aneurysm

Toll-like receptor (TLR) family plays a key role in innate immunity and various inflammatory responses. TLR4, one of the well-characterized pattern-recognition receptors, can be activated by endogenous damage-associated molecular pattern molecules such as high mobility group box 1 (HMGB1) to sustain sterile inflammation. Evidence suggested that blockade of TLR4 signaling may...

Treatment Outcomes of Adenotonsillectomy for Children with Obstructive Sleep Apnea: A Prospective Longitudinal Study

To evaluate the efficacy of adenotonsillectomy (AT) in the treatment of children with obstructive sleep apnea (OSA) in a 3-y prospective, longitudinal study with analysis of risk factors of recurrence of OSA.

Diversity and Antimicrobial Activity of Culturable Endophytic Fungi Isolated from Moso Bamboo Seeds

Bamboos, regarded as therapeutic agents in ethnomedicine, have been used to inhibit inflammation and enhance natural immunity for a long time in Asia, and there are many bamboo associated fungi with medical and edible value. In the present study, a total of 350 fungal strains were isolated from the uncommon moso bamboo (Phyllostachys edulis) seeds for the first time. The...

Rapid and high-efficiency generation of mature functional hepatocyte-like cells from adipose-derived stem cells by a three-step protocol

The generation of functional hepatocytes is a major challenge for regenerative medicine and drug discovery. Here we show a method that facilitates generation of induced functional hepatocytes (iHeps) from adipose-derived stem cells (ADSCs) within 9 days. iHeps express hepatocytic gene programs and display functions characteristic of mature hepatocytes, including cytochrome P450...

Improving early infant HIV diagnosis in Kenya: study protocol of a cluster-randomized efficacy trial of the HITSystem

Background Early infant diagnosis among human immunodeficiency virus (HIV)-exposed infants is a critical component of prevention of mother-to-child transmission programs. Barriers to early infant diagnosis include poor uptake, low retention at designated re-testing intervals, delayed test results, passive systems of communication, and poor linkage to treatment. This study will...

Myxofibrosarcoma of the sinus piriformis: case report and literature review

Myxofibrosarcoma is a common sarcoma in the extremities of older people, but is rare in the head and neck region. Here, we report the case of a 42-year-old male patient in whom myxofibrosarcoma generated from the sinus piriformis. Histopathologically, the tumor was characterized by spindle cellular proliferation with moderate cellular density in fibromyxoid stroma...

Theoretical analysis of a method for segmented heat exchanger design

In the process of the design of heat exchangers, it is difficult to establish the factors governing the optimal points of the design objective functions due to the contradictions and uncertainties of the design objectives. The variation of fluid properties is one of the main factors causing this type of uncertainty. Conventional design methods have not completely solved these...

A Comparison of the Microwave Photoconductivity Decay and Open-Circuit Voltage Decay Lifetime Measurement Techniques for Lifetime-Enhanced 4H-SiC Epilayers

This work compares the optical microwave photoconductivity decay (μPCD) and electrical open-circuit voltage decay (OCVD) techniques for measuring the ambipolar carrier lifetime in 4H-silicon carbide (4H-SiC) epitaxial layers. Lifetime measurements were carried out by fabricating P+/intrinsic/N+ (PiN) diodes on 100-μm-thick, 1 × 1014 cm−3 to 4.5 × 1014 cm−3 doped N-type 4 H-SiC...

Job autonomy, its predispositions and its relation to work outcomes in community health centers in Taiwan

It has been debated that employees in a government or public ownership agency may perceive less need for growth opportunities or high-powered incentives than is the case for employees in private organizations. This study examined employees’ job autonomy in government-run community health centers, its predispositions and its relation to their work outcomes. A cross-sectional study...

Dengue Virus Infection Causes the Activation of Distinct NF-κB Pathways for Inducible Nitric Oxide Synthase and TNF-α Expression in RAW264.7 Cells

University, Taipei 110, Taiwan Received 29 October 2014; Revised 14 April 2015; Accepted 19 May 2015 Academic Editor: Dennis D. Taub Copyright © 2015 Yi-Lin Cheng et al. This is an open access article

RNA-binding protein RNPC1: acting as a tumor suppressor in breast cancer

Jin-Qiu Xue 0 Tian-Song Xia 0 Xiu-Qing Liang Wenbin Zhou Lin Cheng Liang Shi Ying Wang Qiang Ding 0 Equal contributors Jiangsu Breast Disease Center, the First Affiliated Hospital with Nanjing

T cell immunohistochemistry refines lung transplant acute rejection diagnosis and grading

Objective Lung transplant volume has been increasing. However, inaccurate and uncertain diagnosis for lung transplant rejection hurdles long-term outcome due to, in part, interobserver variability in rejection grading. Therefore, a more reliable method to facilitate diagnosing and grading rejection is warranted. Method Rat lung grafts were harvested on day 3, 7, 14 and 28 post...

The entransy dissipation minimization principle under given heat duty and heat transfer area conditions

Under given heat duty and heat transfer area conditions, the equipartition of the entransy dissipation (EoED) principle, the equipartition of the temperature difference (EoTD) principle, and the equipartition of the heat flux (EoHF) principle are applied to the optimization design of a heat exchanger with a variable heat transfer coefficient. The results show that the difference...

Long-term Fluorometholone Topical Use Induces Ganglion Cell Damage in Rats Analyzed With Optical Coherence Tomography

To determine the toxic effects of long-term topical usage of fluorometholone (FLM) on ganglion cells using a direct in vivo retinopathological Brown Norway (BN) rat model. The BN rat retinal model was investigated with a minimum of 3 rats and a maximum of 4 rats per group. Rats received vehicle and 0.02% FLM suspension via topical administration 3 times a day for 28 days. The...

Visualized Gene Network Reveals the Novel Target Transcripts Sox2 and Pax6 of Neuronal Development in Trans-Placental Exposure to Bisphenol A

Background Bisphenol A (BPA) is a ubiquitous endocrine disrupting chemical in our daily life, and its health effect in response to prenatal exposure is still controversial. Early-life BPA exposure may impact brain development and contribute to childhood neurological disorders. The aim of the present study was to investigate molecular target genes of neuronal development in trans...

Systematic Review and Meta-Analysis of 16 Randomized Clinical Trials of Radix Astragali and Its Prescriptions for Diabetic Retinopathy

Editor: Benny Tan Kwong Huat Copyright © 2013 Lin Cheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution