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The Design of a Modified PSO Guidance Law Using Predictor and LOS Rate Evaluation

This paper proposes a modified particle swarm optimization guidance (MPSOG) for the pursuit-evasion optimization problem. If the line-of-sight (LOS) rate equals zero, the curvature of the missile’s trajectory would be smaller and the probability of intercept greater. Thus, we propose using a MPSOG to improve the guidance performance. The MPSOG uses a Kalman filter to predict a...

SULF2 Expression Is a Potential Diagnostic and Prognostic Marker in Lung Cancer

Aims Lung cancer is one of the most deadly cancers; median survival from diagnosis is less than one year in those with advanced disease. Novel lung cancer biomarkers are desperately needed. In this study, we evaluated SULF2 expression by immunohistochemistry and its association with overall survival in a cohort of patients with non-small cell lung cancer (NSCLC). We also looked...

National health insurance and life satisfaction in late life: longitudinal findings from a natural experiment in Taiwan

Background To determine whether the availability of National Health Insurance (NHI) is associated with a longitudinal increase in life satisfaction among older Taiwanese adults.

Impact of chronic rhinosinusitis on severe asthma patients

Coexistence of chronic rhinosinusitis (CRS) with asthma appears to impair asthma control. Type-2 innate lymphoid cells (ILC2s) respond to the cytokines of thymic stromal lymphopoietin (TSLP), interleukin (IL)-25 and IL-33, thus contributing to airway diseases such as CRS and asthma. We investigate whether the augmented Th2-cytokines in CRS might be related to sinonasal tract...

Low-photon-number optical switch and AND/OR logic gates based on quantum dot-bimodal cavity coupling system

. AffiliationsState Key Laboratory of Information Photonics and Optical Communications, Beijing University of Posts and Telecommunications, Beijing 100876, ChinaShen Ma, Han Ye, Zhong-Yuan Yu, Wen Zhang, Yi-Wei Peng ... in:Nature Research journals • PubMed • Google ScholarSearch for Wen Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Yi-Wei Peng in:Nature Research journals • PubMed • Google

Xianfanghuomingyin, a Chinese Compound Medicine, Modulates the Proliferation and Differentiation of T Lymphocyte in a Collagen-Induced Arthritis Mouse Model

, Yi Wei, Meng Chen, and Jingwei Zhou contributed equally to this work. Acknowledgments This work was supported by the National Natural Science Foundation of China (81173228). References K. Andreas

Xianfanghuomingyin, a Chinese Compound Medicine, Modulates the Proliferation and Differentiation of T Lymphocyte in a Collagen-Induced Arthritis Mouse Model

. Competing Interests The authors declare no competing financial interests. Authors? Contributions Bo Nie, Xue Li, Yi Wei, Meng Chen, and Jingwei Zhou contributed equally to this work. Acknowledgments This

Levamisole-Adulterated Cocaine Nephrotoxicity Ultrastructural Features

Objectives: The issue of levamisole-adulterated cocaine is emerging as a rapidly growing public health concern due to an increasing number of reports describing its role in cutaneous vasculitis and agranulocytosis. Of note, levamisole is recognized as a contaminant in 69% of the cocaine used within the United States.

Expression and Functions of CreD, an Inner Membrane Protein in Stenotrophomonas maltophilia

CreBC is a highly conserved two-component regulatory system (TCS) in several gram-negative bacteria, including Escherichia coli, Aeromonas spp., Pseudomonas aeruginosa, and Stenotrophomonas maltophilia. CreD is a conserved gene that encodes a predicted inner-membrane protein and is located near the creBC loci. Activation of CreBC increases creD expression; therefore, creD...

Serum proteomic-based analysis identifying autoantibodies against PRDX2 and PRDX3 as potential diagnostic biomarkers in nasopharyngeal carcinoma

. Carbamidomethylation on Cys was specified as fixed modification. All MS/MS spectra were manually verified. ELISA for autoantibodies ELISA for autoantibodies against PRDX2 and PRDX3 was performed by two researchers (Yi ... -Wei Xu and LieHao Lin) as previously described [13, 18]. Briefly, purified recombinant antigens, PRDX2 (Sino Biological Inc.) and PRDX3 (Abcam, ab168006) were diluted to a final protein concentration of

Alcohol intake and associated risk of major cardiovascular outcomes in women compared with men: a systematic review and meta-analysis of prospective observational studies

Background The prevalence of alcohol intake is increasing among women in some populations. Alcohol consumption plays an important role in the risk of major cardiovascular outcomes and total mortality. Here, we conducted a meta-analysis to estimate the association between alcohol intake and major cardiovascular outcomes or total mortality in women compared with men. Methods We...

Eliciting cytotoxic T lymphocytes against human laryngeal cancer-derived antigens: evaluation of dendritic cells pulsed with a heat-treated tumor lysate and other antigen-loading strategies for dendritic-cell-based vaccination

Background Dendritic cells (DCs) have been used successfully in clinical pilot studies. However, tumor-specific immunity and clinical responses were only induced in certain cancer patients. It has been well documented that immunotherapy efficacy can be optimized for responses using antigen pulsing. Methods The human laryngeal squamous cell cancer (LSCC) cell line SNU899 was used...

Correlation between the Uptake of 18F-Fluorodeoxyglucose (18F-FDG) and the Expression of Proliferation-Associated Antigen Ki-67 in Cancer Patients: A Meta-Analysis

Objective To study the correlation between 18F-FDG uptake and cell proliferation in cancer patients by meta-analysis of published articles. Methods We searched PubMed (MEDLINE included), EMBASE, and Cochrane Database of Systematic Review, and selected research articles on the relationship between 18F-FDG uptake and Ki-67 expression (published between August 1, 1994-August 1, 2014...

c-Myc and viral cofactor Kaposin B co-operate to elicit angiogenesis through modulating miRNome traits of endothelial cells

Background MicroRNAs (miRNAs) have emerged as master regulators of angiogenesis and other cancer-related events. Discovering new angiogenesis-regulating microRNAs (angiomiRs) will eventually help in developing new therapeutic strategies for tumor angiogenesis and cardiovascular diseases. Kaposi’s sarcoma (KS), which is induced by the etiological infectious agent KS-associated...

Inference of high resolution HLA types using genome-wide RNA or DNA sequencing reads

Background Accurate HLA typing at amino acid level (four-digit resolution) is critical in hematopoietic and organ transplantations, pathogenesis studies of autoimmune and infectious diseases, as well as the development of immunoncology therapies. With the rapid adoption of genome-wide sequencing in biomedical research, HLA typing based on transcriptome and whole exome/genome...

Prognostic and clinical significance of claudin-4 in gastric cancer: a meta-analysis

Background The current reports on the association of claudin-4 expression with gastric cancer outcome were inconsistent. Thus, we conducted a meta-analysis to assess the association of claudin-4 expression with the prognosis and clinical parameters more precisely. Methods Systematic searches on PubMed, Embase, and Cochrane Library prior to December 2014 were performed. The pooled...

Comparison of Long-Term Outcomes of Postmastectomy Radiotherapy between Breast Cancer Patients with and without Immediate Flap Reconstruction

Purpose To compare the long-term clinical outcomes of postmastectomy radiotherapy (PMRT) between breast cancer patients with and without immediate transverse rectus abdominis myocutaneous (TRAM) flap reconstruction. Methods The study included 492 patients with stage II or III breast cancer who underwent modified radical mastectomy (MRM) and chemotherapy followed by PMRT between...

DATS suppresses invasion of oral squamous cell carcinoma cell lines by reducing matrix metalloproteinase-9 via PI3K/AKT

Oral squamous cell carcinomas (OSCCs) are the most common type of oral cancers, and high morbidity and mortality are largely attributable to late-stage diagnosis. Despite significant advances in therapeutic strategies, the 5-year survival rate still remains low. Diallyl trisulfide (DATS), an oil-soluble organosulfur compound of garlic, was recently reported for its anticancer...