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Hemoporfin Photodynamic Therapy for Port-Wine Stain: A Randomized Controlled Trial

Background and Objectives Photodynamic therapy (PDT) has shown potentially beneficial results in treating port-wine stain, but its benefit–risk profile remains undefined. This study aimed to evaluate the efficacy and safety of PDT conducted with hemoporfin and a 532 nm continuous wave laser to treat port-wine stain clinically. Patients and Methods This randomized clinical trial...

Impulsive Pinning Markovian Switching Stochastic Complex Networks with Time-Varying Delay

The synchronization problem of stochastic complex networks with Markovian switching and time-varying delays is investigated by using impulsive pinning control scheme. The complex network possesses noise perturbations, Markovian switching, and internal and outer time-varying delays. Sufficient conditions for synchronization are obtained by employing the Lyapunov-Krasovskii...

Evaluation of the Role of Dynamic Contrast-Enhanced MR Imaging for Patients with BI-RADS 3–4 Microcalcifications

Objective The purpose of study was to prospectively evaluate the diagnostic performance of dynamic contrast-enhanced MR imaging in the differentiation of malignant lesions from benign ones in patients with BI-RADS 3–4 microcalcifications detected by mammography. Materials and Methods 93 women with 100 microcalcifications had undergone breast MRI from June 2010 to July 2013...

In vivo evidence of pathogenicity of VPS35 mutations in the Drosophila

Mutations of VPS35, a component of the retromer complex have been associated with late onset familial Parkinson�s disease. The D620N mutation in VPS35 appears to be most prevalent, however, P316S was found in two cases within the same family and a control, whereas L774M was identified in 6 cases and 1 control. In vivo evidence of their pathogenicity is lacking. Here we...

The GSTM1 Null Genotype Increased Risk of Gastric Cancer: A Meta-Analysis Based on 46 Studies

BackgroundGlutathione S-transferases M1 (GSTM1) is an important phase II metabolizing enzyme. The null genotype of GSTM1 causes total loss of GSTM1 enzyme activity and numerous studies have investigated the association between GSTM1 null genotype and gastric cancer risk. MethodsThis meta-analysis was designed to investigate the relationship between GSTM1 null genotype and...

Influence of Seismic Loading on Segment Opening of a Shield Tunnel

The influence of seismic loading on segment opening of a shield tunnel was explored using the dynamic finite element method to analyze the distribution of segment opening under multidirectional seismic loading, combined with a typical engineering installation. The calculation of segment opening was deduced from equivalent continuous theory and segment opening was obtained through...

Preliminary expression profile of cytokines in brain tissue of BALB/c mice with Angiostrongylus cantonensis infection

Background Angiostrongylus cantonensis (A. cantonensis) infection can result in increased risk of eosinophilic meningitis. Accumulation of eosinophils and inflammation can result in the A. cantonensis infection playing an important role in brain tissue injury during this pathological process. However, underlying mechanisms regarding the transcriptomic responses during brain...

Quantum Instanton Evaluations of the Thermal Rate Constants for Complex Systems

, Shaanxi Province, China Received 28 June 2011; Revised 26 August 2011; Accepted 10 September 2011 Academic Editor: Laimutis Bytautas Copyright © 2012 Yi Zhao and Wenji Wang. This is an open access

Cluster Synchronization for Linearly Coupled Complex Networks with Identical and Nonidentical Nodes

University, Guangdong Shenzhen 518060, China Received 11 April 2012; Accepted 7 July 2012 Academic Editor: Hai L. Liu Copyright © 2012 Yi Zhao et al. This is an open access article distributed under the

Pinning Two Nonlinearly Coupled Complex Networks with an Asymmetrical Coupling Matrix

This paper addresses the hybrid synchronization problem in two nonlinearly coupled complex networks with asymmetrical coupling matrices under pinning control schemes. The hybrid synchronization of two complex networks is the outer antisynchronization between the driving network and the response network while the inner complete synchronization in the driving network and the...

The Quaternary Lidocaine Derivative QX-314 Produces Long-Lasting Intravenous Regional Anesthesia in Rats

Background The lidocaine derivative, QX-314, produces long-lasting regional anesthesia in various animal models. We designed this study to examine whether QX-314 could produce long-lasting intravenous regional anesthesia (IVRA) in a rat model. Methods IVRA was performed on tail of rats. EC50 (median effective concentration) of QX-314 in IVRA was determined by up-and-down method...

Effect of Doxorubicin/Pluronic SP1049C on Tumorigenicity, Aggressiveness, DNA Methylation and Stem Cell Markers in Murine Leukemia

National Institutes of Health 2RO1 CA89225, UO1 CA151806, Center of Biomedical Research Excellence (COBRE) Nebraska Center for Nanomedicine 1P20RR021937, and a China Scholarship Council PhD Scholarship (Yi ... Zhao). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: AVK is a co-founder of Supratek Pharma, Inc. He

Lrrk2 R1628P variant is a risk factor for essential tremor

Essential tremor (ET) and Parkinson's disease (PD) are two of the most common adult onset movement disorders with overlapping clinical features. PD patients with leucine-rich repeat kinase-2 (LRRK2) mutations may present initially with an ET phenotype. To address the possibility of a common genetic link between ET and PD, we examined the association between a common LRRK2 R1628P...

NPInter v2.0: an updated database of ncRNA interactions

NPInter (http://www.bioinfo.org/NPInter) is a database that integrates experimentally verified functional interactions between noncoding RNAs (excluding tRNAs and rRNAs) and other biomolecules (proteins, RNAs and genomic DNAs). Extensive studies on ncRNA interactions have shown that ncRNAs could act as part of enzymatic or structural complexes, gene regulators or other functional...

LSD 2.0: an update of the leaf senescence database

This manuscript describes an update of the leaf senescence database (LSD) previously featured in the 2011 NAR Database Issue. LSD provides comprehensive information concerning senescence-associated genes (SAGs) and their corresponding mutants. We have made extensive annotations for these SAGs through both manual and computational approaches. Recently, we updated LSD to a new...

Single nucleotide polymorphism at alcohol dehydrogenase-1B is associated with risk of esophageal squamous cell carcinoma

Background Esophageal squamous incidence in many developed countries has increased dramatically over last decades, while the underlying mechanism of the biogenesis of ES was still unknown. Methods Here, we investigate 1001 subjects with esophageal cancer recruited from the affiliated hospital of Shanghai Jiao Tong University from Jan. 1, 2001 to Feb. 2, 2004. Single nucleotide...

A novel quinone-based polymer electrode for high performance lithium-ion batteries

Designing of high electrochemical performance organic electrode materials has attracted tremendous attention. Recent investigations revealed that quinone-based polymers along with the stable thioether bonds could achieve a high specific capacity and a good cycling stability simultaneously. In this study, we synthesized a novel ladder-structured polymer poly(2,3-dithiino-1,4...

Comprehensive Characterization of 10,571 Mouse Large Intergenic Noncoding RNAs from Whole Transcriptome Sequencing

Large intergenic noncoding RNAs (lincRNAs) have been recognized in recent years to constitute a significant portion of the mammalian transcriptome, yet their biological functions remain largely elusive. This is partly due to an incomplete annotation of tissue-specific lincRNAs in essential model organisms, particularly in mice, which has hindered the genetic annotation and...

Gaussian process regression model for normalization of LC-MS data using scan-level information

Background Differences in sample collection, biomolecule extraction, and instrument variability introduce bias to data generated by liquid chromatography coupled with mass spectrometry (LC-MS). Normalization is used to address these issues. In this paper, we introduce a new normalization method using the Gaussian process regression model (GPRM) that utilizes information from...

Large-scale study of long non-coding RNA functions based on structure and expression features

Mammals and other complex organisms can transcribe an abundance of long non-coding RNAs (lncRNAs) that fulfill a wide variety of regulatory roles in many biological processes. These roles, including as scaffolds and as guides for protein-coding genes, mainly depend on the structure and expression level of lncRNAs. In this review, we focus on the current methods for analyzing...