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Identifying ultrasound and clinical features of breast cancer molecular subtypes by ensemble decision

Breast cancer is molecularly heterogeneous and categorized into four molecular subtypes: Luminal-A, Luminal-B, HER2-amplified and Triple-negative. In this study, we aimed to apply an ensemble decision approach to identify the ultrasound and clinical features related to the molecular subtypes. We collected ultrasound and clinical features from 1,000 breast cancer patients and...

Differential Natural Selection of Human Zinc Transporter Genes between African and Non-African Populations

of this manuscript. All funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Author information Author notesChao Zhang & Jing Li ... Partner Institute for Computational Biology (PICB), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, ChinaChao Zhang, Jing Li, Lei Tian, Dongsheng Lu, Kai Yuan

Suberoylanilide Hydroxamic Acid Treatment Reveals Crosstalks among Proteome, Ubiquitylome and Acetylome in Non-Small Cell Lung Cancer A549 Cell Line

Suberoylanilide hydroxamic acid (SAHA) is a well-known histone deacetylase (HDAC) inhibitor and has been used as practical therapy for breast cancer and non-small cell lung cancer (NSCLC). It is previously demonstrated that SAHA treatment could extensively change the profile of acetylome and proteome in cancer cells. However, little is known about the impact of SAHA on other...

Trek1 contributes to maintaining nasal epithelial barrier integrity

Epithelial barrier integrity is critical to maintain the homeostasis in the body. The regulatory mechanism of the epithelial barrier function has not been fully understood. This study aims to elucidate the role of the TWIK-related potassium channel-1 (Trek1) in the regulation of the epithelial barrier function of the nasal mucosa. In this study, the levels of Trek1 were assessed...

Microstructural Abnormalities in Children with Post-traumatic Stress Disorder: A Diffusion Tensor Imaging Study at 3.0T

in:Nature Research journals • PubMed • Google ScholarSearch for Su Lui in:Nature Research journals • PubMed • Google ScholarSearch for Jing Li in:Nature Research journals • PubMed • Google ScholarSearch for

Aurora B-dependent phosphorylation of Ataxin-10 promotes the interaction between Ataxin-10 and Plk1 in cytokinesis

ScholarSearch for Jing Li in:Nature Research journals • PubMed • Google Scholar Contributions J.Li. wrote the manuscript; J.Li., M.-Q.D. and X.X. designed the project and analyzed the data; J.T., C.T., Y.D., Z.L ... Correspondence to Xingzhi Xu or Jing Li. Supplementary information PDF files1.Supplementary Information Supplemental information Rights and permissions This work is licensed under a Creative Commons

Aggregation of polyglutamine-expanded ataxin-3 sequesters its specific interacting partners into inclusions: Implication in a loss-of-function pathology

Expansion of polyglutamine (polyQ) tract may cause protein misfolding and aggregation that lead to cytotoxicity and neurodegeneration, but the underlying mechanism remains to be elucidated. We applied ataxin-3 (Atx3), a polyQ tract-containing protein, as a model to study sequestration of normal cellular proteins. We found that the aggregates formed by polyQ-expanded Atx3...

Synergism and Rules of the new Combination drug Yiqijiedu Formulae (YQJD) on Ischemic Stroke based on amino acids (AAs) metabolism

Ding-Rong Yu in:Nature Research journals • PubMed • Google ScholarSearch for Hong-Jun Yang in:Nature Research journals • PubMed • Google ScholarSearch for Shao-Jing Li in:Nature Research journals ... . Corresponding authors Correspondence to Hong-Jun Yang or Shao-Jing Li. Supplementary information Word documents1.Supplementary Information Supplementary materials Rights and permissions This work is

Digital reconstruction of the cell body in dense neural circuits using a spherical-coordinated variational model

Mapping the neuronal circuits is essential to understand brain function. Recent technological advancements have made it possible to acquire the brain atlas at single cell resolution. Digital reconstruction of the neural circuits down to this level across the whole brain would significantly facilitate brain studies. However, automatic reconstruction of the dense neural connections...

The relationship between moral judgment and cooperation in children with high-functioning autism

Behavioral Science, Institute of Psychology, Chinese Academy of SciencesJing Li & Liqi ZhuSchool of Psychology, University of Plymouth, Plymouth, UKMichaela Gummerum AuthorsSearch for Jing Li in:Nature

Plasmonic Amplification with Ultra-High Optical Gain at Room Temperature

Nanoplasmonic devices are promising for next generation information and communication technologies because of their capability to confine light at subwavelength scale and transport signals with ultrahigh speeds. However, ohmic losses are inherent to all plasmonic devices so that further development of integrated plasmonics requires efficient in situ loss compensation of signals...

Metagenomic and metabolomic analyses unveil dysbiosis of gut microbiota in chronic heart failure patients

Previous studies suggested a possible gut microbiota dysbiosis in chronic heart failure (CHF). However, direct evidence was lacking. In this study, we investigated the composition and metabolic patterns of gut microbiota in CHF patients to provide direct evidence and comprehensive understanding of gut microbiota dysbiosis in CHF. We enrolled 53 CHF patients and 41 controls...

Numerical Investigation of Damage Risks of Roadway Surrounding Rocks under Oblique Incident Dynamic Loads

In order to quantitatively demonstrate the damage risks of roadway surrounding rocks and meanwhile comprehensively consider stress states of surrounding rocks, an index to evaluate damage hazards was established based on Mohr-Coulomb strength criterion. Taking the track roadway of Longwall Panel 402103 in Hujiahe Coal Mine as an example, damage risks and dynamic response...

Magnetoelastic Principal Parametric Resonance of a Rotating Electroconductive Circular Plate

Nonlinear principal parametric resonance and stability are investigated for rotating circular plate subjected to parametric excitation resulting from the time-varying speed in the magnetic field. According to the conductive rotating thin circular plate in magnetic field, the magnetoelastic parametric vibration equations of a conductive rotating thin circular plate are deduced by...

Multi-Fault Feature Extraction and Diagnosis of Gear Transmission System Using Time-Frequency Analysis and Wavelet Threshold De-Noising Based on EMD

Wentao Hu 0 Jing Li 0 0 School of Mechatronics, Northwestern Polytechnical University , Xi'an, Shaanxi , China A gear transmission system is a complex non-stationary and nonlinear time-varying coupling

Multi-Fault Feature Extraction and Diagnosis of Gear Transmission System Using Time-Frequency Analysis and Wavelet Threshold De-Noising Based on EMD

Wentao Hu 0 Jing Li 0 0 School of Mechatronics, Northwestern Polytechnical University , Xi'an, Shaanxi , China A gear transmission system is a complex non-stationary and nonlinear time-varying coupling

DUP1 peptide modified micelle efficiently targeted delivery paclitaxel and enhance mitochondrial apoptosis on PSMA-negative prostate cancer cells

Li Xuehua Jiang Lulu Cai Xiang Li Prostate tumor cell targeted peptide fragment conjugated to the nano drug delivery system is a promising strategy for prostate cancer therapy. In this work, an

Can pelvic lymphadenectomy be omitted in patients with stage IA2, IB1, and IIA1 squamous cell cervical cancer?

Purpose This study aimed to identify the surgical-pathologic risk factors of lymph node metastasis (LNM) in patients with early stage squamous cell cervical cancer and to evaluate the potential efficacy of omitting pelvic lymphadenectomy. Methods A total of 276 patients with stage IA2, IB1, and IIA1 squamous cell cervical cancer receiving primary radical hysterectomy with pelvic...

Global budget payment system helps to reduce outpatient medical expenditure of hypertension in China

BackgroundAs healthcare spending continues to increase, medical insurance is now under great pressure of growing economic burden. To control the excessive growth of medical expenditure, change of medical payment system was clearly put forward in China’s new healthcare reform. With this end, Tianjin, a large city in North China, is now exploring to replace traditional fee-for...

Mutation detection in Chinese patients with familial hypercholesterolemia

BackgroundFamilial hypercholesterolemia (FH) is the first molecularly and clinically characterized genetic disease of lipid metabolism. It is an autosomal dominant disorder with significantly elevated levels of total cholesterol and low density of lipoprotein cholesterol in serum, which would lead to extensive xanthomas and premature coronary heart disease. Mutations in low...