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Etoposide Induces Apoptosis in Activated Human Hepatic Stellate Cells via ER Stress

Tower Clinical Medical School of Nanjing Medical University, Nanjing, ChinaMingcui Xu AuthorsSearch for Chen Wang in:Nature Research journals • PubMed • Google ScholarSearch for Feng Zhang in:Nature

Numerical and experimental investigation of light trapping effect of nanostructured diatom frustules

, CBET-1055379, and CBET-1066776. Author information AffiliationsMechanical Engineering Department, Northwestern University, Evanston, IL 60208, USAXiangfan Chen, Chen Wang, Evan Baker & Cheng Sun ... AuthorsSearch for Xiangfan Chen in:Nature Research journals • PubMed • Google ScholarSearch for Chen Wang in:Nature Research journals • PubMed • Google ScholarSearch for Evan Baker in:Nature Research journals

Elevated Serum Uric Acid Is Associated with Greater Bone Mineral Density and Skeletal Muscle Mass in Middle-Aged and Older Adults

Background and objective Previous studies have suggested a positive link between serum uric acid (UA) and bone mineral density (BMD). In this study, we re-examined the association between UA and BMD and further explored whether this was mediated by skeletal muscle mass in a general Chinese population. Method This community-based cross-sectional study was conducted among 3079 (963...

A comparison of beliefs about exercise during pregnancy between Chinese and Australian pregnant women

Science , Exercise and Health , The University of Western Australia , 35 Stirling Highway, Crawley, Western Australia 6009 , Australia 2 Kym J. Guelfi and Chen Wang are co-first authors 3 School of Women's

Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer

, Chen-Yu Zhang, Tao Wang, Chen wang, Junfeng Zhang, and Xi Chen declare that they have no competing interests. All procedures followed were in accordance with the ehhical standards of the responsible

Preparation of arginine–glycine–aspartic acid-modified biopolymeric nanoparticles containing epigalloccatechin-3-gallate for targeting vascular endothelial cells to inhibit corneal neovascularization

Che-Yi Chang,1,2,* Ming-Chen Wang,2,* Takuya Miyagawa,1 Zhi-Yu Chen,1 Feng-Huei Lin,3,4 Ko-Hua Chen,5,6 Guei-Sheung Liu,7 Ching-Li Tseng1 1Graduate Institute of Biomedical Materials and Tissue

The optimum timing to wean invasive ventilation for patients with AECOPD or COPD with pulmonary infection

The optimum timing to wean invasive ventilation for patients with AECOPD or COPD with pulmonary infection Yuanlin Song,1 Rongchang Chen,2 Qingyuan Zhan,3 Shujing Chen,1 Zujin Luo,4 Jiaxian Ou,1 Chen Wang3 1Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, 2Guangzhou Institute of Respiratory Disease, Guangzhou, 3Department of Respiratory and...

Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Promotes Hepatic Stellate Cells Migration via Canonical NF-κB/MMP9 Pathway

In the liver, the signal and function of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) have mainly been assessed in association with liver regeneration. However, the effects of TWEAK on liver fibrosis have not been fully elucidated. To investigate the effects of TWEAK on human hepatic stellate cells (HSCs) and to explore the relevant potential mechanisms, human...

Cloning and molecular identification of triosephosphate isomerase gene from Apis cerana cerana and its role in response to various stresses

Apis cerana cerana triosephosphate isomerase (AccTPI), a key regulatory enzyme in glycolysis and gluconeogenesis pathway, catalyzes the interconversion of glyceraldehyde 3-phosphate to dihydroxyacetone phosphate. However, its role in A. cerana cerana has not been completely clarified. In this study, a TPI gene was cloned from A. cerana cerana and named AccTPI. The open reading...

Follistatin-like 1 protects against hypoxia-induced pulmonary hypertension in mice

WangBeijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Capital Medical University, Beijing 100069, P.R. ChinaWei Zhang, Wang Wang, Jie Liu, Zhifei Zhang, Yafei Liu, Chen Wang & Jun ... • Google ScholarSearch for Jifeng Li in:Nature Research journals • PubMed • Google ScholarSearch for Jie Cao in:Nature Research journals • PubMed • Google ScholarSearch for Chen Wang in:Nature Research

Dynamin-related protein 1 is involved in micheliolide-induced breast cancer cell death

Dynamin-related protein 1 is involved in micheliolide-induced breast cancer cell death Yongsheng Jia,1,2 Liyan Zhou,1,2 Chen Tian,3 Yehui Shi,1,2 Chen Wang,1,2 Zhongsheng Tong1,2 1Department of

The Predictive Effects of Early Pregnancy Lipid Profiles and Fasting Glucose on the Risk of Gestational Diabetes Mellitus Stratified by Body Mass Index

, China Received 9 November 2015; Accepted 13 January 2016 Academic Editor: Andrea Tura Copyright © 2016 Chen Wang et al. This is an open access article distributed under the Creative Commons ... . Conflict of Interests The authors have declared no conflict of interests. Authors’ Contribution Chen Wang was involved in the collection and analysis of the data as well as drafting of the paper. Weiwei Zhu

An Optimal Allocation Model of Public Transit Mode Proportion for the Low-Carbon Transportation

Public transit has been widely recognized as a potential way to develop low-carbon transportation. In this paper, an optimal allocation model of public transit mode proportion (MPMP) has been built to achieve the low-carbon public transit. Optimal ratios of passenger traffic for rail, bus, and taxi are derived by running the model using typical data. With different values of...

Alteration in Expression and Methylation of IGF2/H19 in Placenta and Umbilical Cord Blood Are Associated with Macrosomia Exposed to Intrauterine Hyperglycemia

Objective Macrosomia is one of the most common complications in gestational diabetes mellitus. Insulin-like growth factor 2 and H19 are two of the imprinted candidate genes that are involved in fetal growth and development. Change in methylation at differentially methylated region of the insulin-like growth factor 2 and H19 has been proved to be an early event related to the...

Extra-Nuclear Signaling Pathway Involved in Progesterone-Induced Up-Regulations of p21cip1 and p27kip1 in Male Rat Aortic Smooth Muscle Cells

Previously, we demonstrated that progesterone (P4) at physiologic levels (5-500 nM) inhibited proliferation in cultured rat aortic smooth muscle cells (RASMCs) through a P4 receptor (PR)-dependent pathway. We also showed that P4-induced cell cycle arrest in RASMCs occurs when the cyclin-CDK2 system is inhibited just as p21cip1 and p27kip1 protein levels are augmented. In the...

Modulation Effect of Peroxisome Proliferator-Activated Receptor Agonists on Lipid Droplet Proteins in Liver

Peroxisome proliferator-activated receptor (PPAR) agonists are used for treating hyperglycemia and type 2 diabetes. However, the mechanism of action of these agonists is still under investigation. The lipid droplet-associated proteins FSP27/CIDEC and LSDP5, regulated directly by PPARγ and PPARα, are associated with hepatic steatosis and insulin sensitivity. Here, we evaluated the...

Exercise intervention during pregnancy can be used to manage weight gain and improve pregnancy outcomes in women with gestational diabetes mellitus

Background The study aimed to evaluate whether exercise intervention can be applied to pregnant women with gestational diabetes mellitus (GDM) for controlling gestational weight gain (GWG) and combating GDM-related outcomes. Methods Retrospective six months analysis of 14,168 single pregnant women without diabetes from 15 hospitals in Beijing in 2013. Each participant’s...

Risk alleles for IgA nephropathy-associated SNPs conferred completely opposite effects to idiopathic membranous nephropathy in Chinese Han

were found to be significantly associated with the susceptibility of IMN, with rs9275596 as the top one (p = 1.97E-43, Xiaosong Qin and Chen Wang contributed equally to the work. - Department of

Inhibitory effects of hesperetin on Nav1.5 channels stably expressed in HEK 293 cells and on the voltage-gated cardiac sodium current in human atrial myocytes

, and Xin-ling DU designed the study; Huan WANG, Hao ZHANG, Chen WANG, and Yu-fang CHEN performed the experiments; Huan WANG and Rong MA analyzed the data; Hong-fei WANG, Chen WANG, and Yu-fang CHEN ... , Huazhong University of Science and Technology, Wuhan 430030, ChinaHuan Wang, Chen Wang, Yu-fang Chen, Rong Ma, Ji-zhou Xiang & Qiang TangDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical