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Synthesis and Evaluation of In Vitro Antibacterial and Antitumor Activities of Novel N,N-Disubstituted Schiff Bases

Medical University, Guizhou 550025, China Correspondence should be addressed to Wei-dong Pan; moc.361@napdw and Xiao-dong Zhang; ten.362@185dxz Received 29 November 2016; Revised 8 February 2017; Accepted

Synthesis and Evaluation of In Vitro Antibacterial and Antitumor Activities of Novel N,N-Disubstituted Schiff Bases

Medical University, Guizhou 550025, China Correspondence should be addressed to Wei-dong Pan; moc.361@napdw and Xiao-dong Zhang; ten.362@185dxz Received 29 November 2016; Revised 8 February 2017; Accepted

Synthesis and Evaluation of In Vitro Antibacterial and Antitumor Activities of Novel N,N-Disubstituted Schiff Bases

Medical University, Guizhou 550025, China Correspondence should be addressed to Wei-dong Pan; moc.361@napdw and Xiao-dong Zhang; ten.362@185dxz Received 29 November 2016; Revised 8 February 2017; Accepted

Defective autophagy leads to the suppression of stem-like features of CD271 + osteosarcoma cells

Background As an important stress-response mechanism, autophagy plays crucial role in the tumor formation and drug resistance of cancer cells including osteosarcoma (OS). OS cancer stem cells (CSCs) also are considered a key factor of tumorigenesis, drug resistance and tumor recurrence. However, the relationship between autophagy and OS CSCs still remains unclear. Methods CD271...

A Rate-Distortion Optimized Coding Method for Region of Interest in Scalable Video Coding

The support for region of interest (ROI) browsing, which allows dropping background part of video bitstreams, is a desirable feature for video applications. With the help of the slice group technique provided by H.264/SVC, rectangular ROI areas can be encoded into separate ROI slices. Additionally, by imposing certain constraints on motion estimation, ROI part of the bitstream...

A Rate-Distortion Optimized Coding Method for Region of Interest in Scalable Video Coding

The support for region of interest (ROI) browsing, which allows dropping background part of video bitstreams, is a desirable feature for video applications. With the help of the slice group technique provided by H.264/SVC, rectangular ROI areas can be encoded into separate ROI slices. Additionally, by imposing certain constraints on motion estimation, ROI part of the bitstream...

Molecular Characterization and Functional Analysis of Annulate Lamellae Pore Complexes in Nuclear Transport in Mammalian Cells

Annulate lamellae are cytoplasmic organelles containing stacked sheets of membranes embedded with pore complexes. These cytoplasmic pore complexes at annulate lamellae are morphologically similar to nuclear pore complexes at the nuclear envelope. Although annulate lamellae has been observed in nearly all types of cells, their biological functions are still largely unknown. Here...

Rapamycin/sodium hyaluronate binding on nano-hydroxyapatite coated titanium surface improves MC3T3-E1 osteogenesis

Endosseous titanium (Ti) implant failure due to poor biocompatibility of implant surface remains a major problem for osseointegration. Improving the topography of Ti surface may enhance osseointegration, however, the mechanism remains unknown. To investigate the effect of modified Ti surface on osteogenesis, we loaded rapamycin (RA) onto nano-hydroxyapatite (HAp) coated Ti...

Efficient Gene Knockdown in Mouse Oocytes through Peptide Nanoparticle-Mediated SiRNA Transfection

The use of mouse oocytes as a model for studying female meiosis is very important in reproductive medicine. Gene knockdown by specific small interfering RNA (siRNA) is usually the first step in the study of the function of a target gene in mouse oocytes during in vitro maturation. Traditionally, the only way to introduce siRNA into mouse oocytes is through microinjection, which...

Population Structure and Adaptive Divergence in a High Gene Flow Marine Fish: The Small Yellow Croaker (Larimichthys polyactis)

The spatial distribution of genetic diversity has been long considered as a key component of policy development for management and conservation of marine fishes. However, unraveling the population genetic structure of migratory fish species is challenging due to high potential for gene flow. Despite the shallow population differentiation revealed by putatively neutral loci, the...

In vivo and in vitro performance of a China-made hemodialysis machine: a multi-center prospective controlled study

To evaluate the in vivo and in vitro performance of a China-made dialysis machine (SWS-4000). This was a multi-center prospective controlled study consisting of both long-term in vitro evaluations and cross-over in vivo tests in 132 patients. The China-made SWS-4000 dialysis machine was compared with a German-made dialysis machine (Fresenius 4008) with regard to Kt/V values, URR...

Genome-Wide SNP Discovery, Genotyping and Their Preliminary Applications for Population Genetic Inference in Spotted Sea Bass (Lateolabrax maculatus)

Next-generation sequencing and the collection of genome-wide single-nucleotide polymorphisms (SNPs) allow identifying fine-scale population genetic structure and genomic regions under selection. The spotted sea bass (Lateolabrax maculatus) is a non-model species of ecological and commercial importance and widely distributed in northwestern Pacific. A total of 22 648 SNPs was...

Mitochondrial-dependent mechanisms are involved in angiotensin II-induced apoptosis in dopaminergic neurons

Introduction: We recently demonstrated that angiotensin II (Ang II) was involved in the etiology of Parkinson’s disease (PD) via induction of apoptosis of dopaminergic neurons, but the mechanisms are not completely elucidated. Here, we asked whether mitochondrial-dependent mechanisms contributed to the Ang II-induced dopaminergic neuronal apoptosis.

miR-511 promotes the proliferation of human hepatoma cells by targeting the 3′UTR of B cell translocation gene 1 (BTG1) mRNA

and Treatment of Key Infectious Diseases (No 2014ZX0002002-005). Author contribution Xiao-dong ZHANG conceived the projects; Xiao-dong ZHANG, Jun-qi NIU and Li-hong YE designed the experiments and

The prognostic significance of DAPK1 in bladder cancer

Bladder cancer is one of the leading causes of cancer-related death in men, however, there was only limited effective treatment for invasive bladder cancer. DAPK1 has been shown to play important role in apoptosis and autophagy to suppress cancer progression. Previous results have shown that DAPK1 promoter was hypermethylated in the majority of bladder cancer specimens, however...

Computational cancer biology: education is a natural key to many locks

Background Oncology is a field that profits tremendously from the genomic data generated by high-throughput technologies, including next-generation sequencing. However, in order to exploit, integrate, visualize and interpret such high-dimensional data efficiently, non-trivial computational and statistical analysis methods are required that need to be developed in a problem...

ZP3 is Required for Germinal Vesicle Breakdown in Mouse Oocyte Meiosis

-Lei Gao, Chun-Xiang Zhou, Xiao-Lan Zhang, Peng Liu, Zhen Jin, Gang-Yi Zhu, Yang Ma, Jing Li, Zhi-Xia Yang & Dong Zhang AuthorsSearch for Lei-Lei Gao in:Nature Research journals • PubMed • Google ... for Dong Zhang in:Nature Research journals • PubMed • Google Scholar Contributions D.Z., Z.-X.Y. and J.L. designed research; L.-L.G., and C.-X.Z. performed most of the experiments and data analysis; X

What’s Wrong with the Murals at the Mogao Grottoes: A Near-Infrared Hyperspectral Imaging Method

). Author information AffiliationsSchool of Computer Science, Tianjin University, Tianjin, ChinaMeijun Sun, Dong Zhang & Jizhou SunSchool of Computer Software, Tianjin University, Tianjin, ChinaZheng ... • PubMed • Google ScholarSearch for Dong Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Zheng Wang in:Nature Research journals • PubMed • Google ScholarSearch for Jinchang Ren

Effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy

Xiao-Dong Zhang 3 4 0 Tianjin Key l aboratory of r adiation Medicine and Molecular Nuclear Medicine, Institute of r adiation Medicine, c hinese a cademy of Medical s ciences and Peking Union Medical

Surface Corrosion Resistance in Turning of Titanium Alloy

This work addresses the issues associated with implant surface modification. We propose a method to form the oxide film on implant surfaces by dry turning to generate heat and injecting oxygen-rich gas at the turning-tool flank. The morphology, roughness, composition, and thickness of the oxide films in an oxygen-rich atmosphere were characterized using scanning electron...