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Research on compression-rod lock–release mechanism with large load for space manipulator

With the development of Chinese space station, the space manipulator with large load plays a more and more important role. At the same time, the lock–release mechanism for the space manipulator must be reliable. In this study, the locking point layout method was proposed according to the size and the structure of the space manipulator, and the number and the position of the lock...

SDF1–CXCR4 signaling contributes to persistent pain and hypersensitivity via regulating excitability of primary nociceptive neurons: involvement of ERK-dependent Nav1.8 up-regulation

Background Pain is one critical hallmark of inflammatory responses. A large number of studies have demonstrated that stromal cell-derived factor 1 (SDF1, also named as CXCL12) and its cognate receptor C-X-C chemokine receptor type 4 (CXCR4) play an important role in immune reaction and inflammatory processes. However, whether and how SDF1–CXCR4 signaling is involved in...

SUMOylation of Mouse p53b by SUMO-1 Promotes Its Pro-Apoptotic Function in Ovarian Granulosa Cells

Follicular atresia is a process of spontaneous degradation of follicles, hindering growth and development in the mammalian ovary. Previous studies showed that follicular atresia was caused by apoptosis of granulosa cells, for which a number of apoptosis-related genes have already been identified. The roles of p53 in apoptosis of mouse granulosa cells and its post-translational...

Selenium Inhibits Root Elongation by Repressing the Generation of Endogenous Hydrogen Sulfide in Brassica rapa

Selenium (Se) has been becoming an emerging pollutant causing severe phytotoxicity, which the biochemical mechanism is rarely known. Although hydrogen sulfide (H2S) has been suggested as an important exogenous regulator modulating plant physiological adaptions in response to heavy metal stress, whether and how the endogenous H2S regulates Se-induce phytotoxicity remains unclear...

Single-dose pharmacokinetic and toxicity analysis of pyrrole–imidazole polyamides in mice

PurposePyrrole–imidazole (Py-Im) polyamides are programmable, sequence-specific DNA minor groove–binding ligands. Previous work in cell culture has shown that various polyamides can be used to modulate the transcriptional programs of oncogenic transcription factors. In this study, two hairpin polyamides with demonstrated activity against androgen receptor signaling in cell...

Splicing proofreading at 5′ splice sites by ATPase Prp28p

Fidelity and efficiency of pre-mRNA splicing are critical for generating functional mRNAs, but how such accuracy in 5′ splice site (SS) selection is attained is not fully clear. Through a series of yeast genetic screens, we isolated alleles of prp28 that improve splicing of suboptimal 5′SS substrates, demonstrating that WT-Prp28p proofreads, and consequently rejects, poor 5′SS...

Stochastic Control-Oriented Modeling of Flexible Air-Breathing Hypersonic Vehicle

, Xi’an 710038, China 2Research Center for Evaluation and Argumentation, Academy of Military Science, Beijing 100091, China Correspondence should be addressed to Peng-fei Yang; moc.621@8891gnayfp Received

Structure and properties of indium-doped ZnO films prepared by RF magnetron sputtering under different pressures

High conductive and transparent In-doped ZnO thin films were deposited on glass substrates by radio-frequency (RF) magnetron sputtering at 250 °C. Argon gas was used as the sputtering gas, and its pressure varies from 0.1 to 4.0 Pa. The influences of deposition pressure on the structural, electrical and optical properties of the films were investigated by means of X-ray...

Substance P Promotes the Proliferation, but Inhibits Differentiation and Mineralization of Osteoblasts from Rats with Spinal Cord Injury via RANKL/OPG System

Spinal cord injury (SCI) causes a significant amount of bone loss, which results in osteoporosis (OP). The neuropeptide substance P (SP) and SP receptors may play important roles in the pathogenesis of OP after SCI. To identify the roles of SP in the bone marrow mesenchymal stem cell derived osteoblasts (BMSC-OB) in SCI rats, we investigated the expression of neurokinin-1...

Targeted inhibition of the phosphoinositide 3-kinase impairs cell proliferation, survival, and invasion in colon cancer

Targeted inhibition of the phosphoinositide 3-kinase impairs cell proliferation, survival, and invasion in colon cancer Fei Yang,1,* Jun-Yi Gao,2,* Hua Chen,1 Zhen-Hua Du,1 Xue-Qun Zhang,3 Wei Gao4

The Adjoint Method for the Inverse Problem of Option Pricing

The estimation of implied volatility is a typical PDE inverse problem. In this paper, we propose the model for identifying the implied volatility. The optimal volatility function is found by minimizing the cost functional measuring the discrepancy. The gradient is computed via the adjoint method which provides us with an exact value of the gradient needed for the minimization...

The Adjoint Method for the Inverse Problem of Option Pricing

The estimation of implied volatility is a typical PDE inverse problem. In this paper, we propose the model for identifying the implied volatility. The optimal volatility function is found by minimizing the cost functional measuring the discrepancy. The gradient is computed via the adjoint method which provides us with an exact value of the gradient needed for the minimization...

The Endogenous Nitric Oxide Mediates Selenium-Induced Phytotoxicity by Promoting ROS Generation in Brassica rapa

Selenium (Se) is suggested as an emerging pollutant in agricultural environment because of the increasing anthropogenic release of Se, which in turn results in phytotoxicity. The most common consequence of Se-induced toxicity in plants is oxidative injury, but how Se induces reactive oxygen species (ROS) burst remains unclear. In this work, histofluorescent staining was applied...

The Soluble Form of the EIAV Receptor Encoded by an Alternative Splicing Variant Inhibits EIAV Infection of Target Cells

Equine lentivirus receptor 1 (ELR1) has been identified as the sole receptor for equine infectious anemia virus (EIAV) and is a member of the tumor necrosis factor receptor (TNFR) superfamily. In addition to the previously described membrane-associated form of ELR1, two other major alternative splicing variant mRNAs were identified in equine monocyte-derived macrophages (eMDMs...

The association between pulse pressure and vascular access thrombosis in chronic hemodialysis patients

Medical University Hospital, Taichung, TaiwanChe-Yi Chou, Jiung-Hsiun Liu, Huey-Liang Kuo, Yao-Lung Liu, Hsin-Hung Lin, Ya-Fei Yang, Shu-Ming Wang & Chiu-Ching Huang AuthorsSearch for Che-Yi Chou in:Nature ... ScholarSearch for Yao-Lung Liu in:Nature Research journals • PubMed • Google ScholarSearch for Hsin-Hung Lin in:Nature Research journals • PubMed • Google ScholarSearch for Ya-Fei Yang in:Nature Research journals

The development of the own-race advantage in school-age children: A morphing face paradigm

, the child participants and their parents for joining the study. Author Contributions Conceptualization: Sarina Hui-Lin Chien. Data curation: Chu-Lik Tai, Shu-Fei Yang. Formal analysis: Sarina Hui ... -Lin Chien, Shu-Fei Yang. Funding acquisition: Sarina Hui-Lin Chien. Investigation: Chu-Lik Tai. Methodology: Sarina Hui-Lin Chien, Chu-Lik Tai, Shu-Fei Yang. Project administration: Sarina Hui-Lin

The embodiment of emotion: language use during the feeling of social emotions predicts cortical somatosensory activity

Complex social emotions involve both abstract cognitions and bodily sensations, and individuals may differ on their relative reliance on these. We hypothesized that individuals’ descriptions of their feelings during a semi-structured emotion induction interview would reveal two distinct psychological styles—a more abstract, cognitive style and a more body-based, affective style...

The prevalence of primary headache disorders and their associated factors among nursing staff in North China

Background Epidemiological data on the prevalence of headache in nursing staff in Mainland China are lacking. We therefore performed a study to assess the prevalence of headache, and factors associated with headaches, in nursing staff in three hospitals in North China. Methods Stratified random cluster sampling was used to select 1102 nurses from various departments in three...