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?-Well-Posedness for Mixed Quasi Variational-Like Inequality Problems

January 2011; Revised 18 March 2011; Accepted 14 April 2011 Academic Editor: V. Zeidan Copyright © 2011 Jian-Wen Peng and Jing Tang. This is an open access article distributed under the Creative ... Inequality Problems Jian-Wen Peng and Jing Tang School of Mathematics, Chongqing Normal University, Chongqing 400047, China Received 15 January 2011; Revised 18 March 2011; Accepted 14 April 2011 Academic

Association of Lipidome Remodeling in the Adipocyte Membrane with Acquired Obesity in Humans

The authors describe a new approach to studying cellular lipid profiles and propose a compensatory mechanism that may help maintain the normal membrane function of adipocytes in the context of obesity.

Polymerization of aniline under various concentrations of APS and HCl

Effects from various initial molar ratios of aniline (AN), ammonium peroxydisulfate (APS) and HCl ([AN]:[APS]:[HCl]) on the polymerization of AN were investigated. First, a scheme derived from a molecular point of view was proposed to distinguish formation mechanisms based on their initial conditions. Thereafter, by choosing a relatively low ratio of [APS]/[AN]=0.23 at [AN]=0.27...

Metabolome in schizophrenia and other psychotic disorders: a general population-based study

Background Persons with schizophrenia and other psychotic disorders have a high prevalence of obesity, impaired glucose tolerance, and lipid abnormalities, particularly hypertriglyceridemia and low high-density lipoprotein. More detailed molecular information on the metabolic abnormalities may reveal clues about the pathophysiology of these changes, as well as about disease...

Drosophila FMRP regulates microtubule network formation and axonal transport of mitochondria

Fragile X syndrome, the most common form of inherited mental retardation, is caused by the absence of the fragile X mental retardation protein FMRP. The RNA-binding FMRP represses translation of the microtubule (MT)-associated protein 1B (MAP1B) during synaptogenesis in the brain of the neonatal mouse. However, the effect of FMRP on MTs remains unclear. Mounting evidence shows...

VHZ is a novel centrosomal phosphatase associated with cell growth and human primary cancers

Background VHZ is a VH1-like (member Z) dual specific protein phosphatase encoded by DUSP23 gene. Some of the dual specific protein phosphatases (DSPs) play an important role in cell cycle control and have shown to be associated with carcinogenesis. Here, the expression of VHZ associated with cell growth and human cancers was investigated. Results We generated a mouse monoclonal...

Identifying Currents in the Gene Pool for Bacterial Populations Using an Integrative Approach

The evolution of bacterial populations has recently become considerably better understood due to large-scale sequencing of population samples. It has become clear that DNA sequences from a multitude of genes, as well as a broad sample coverage of a target population, are needed to obtain a relatively unbiased view of its genetic structure and the patterns of ancestry connected to...

Integrating post-genomic approaches as a strategy to advance our understanding of health and disease

Following the publication of the complete human genomic sequence, the post-genomic era is driven by the need to extract useful information from genomic data. Genomics, transcriptomics, proteomics, metabolomics, epidemiological data and microbial data provide different angles to our understanding of gene-environment interactions and the determinants of disease and health. Our goal...

Enhanced Bayesian modelling in BAPS software for learning genetic structures of populations

Background During the most recent decade many Bayesian statistical models and software for answering questions related to the genetic structure underlying population samples have appeared in the scientific literature. Most of these methods utilize molecular markers for the inferences, while some are also capable of handling DNA sequence data. In a number of earlier works, we have...

Computer-Aided Lead Optimization: Improved Small-Molecule Inhibitor of the Zinc Endopeptidase of Botulinum Neurotoxin Serotype A

Optimization of a serotype-selective, small-molecule inhibitor of botulinum neurotoxin serotype A (BoNTA) endopeptidase is a formidable challenge because the enzyme-substrate interface is unusually large and the endopeptidase itself is a large, zinc-binding protein with a complex fold that is difficult to simulate computationally. We conducted multiple molecular dynamics...