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Temperature Stress Mediates Decanalization and Dominance of Gene Expression in Drosophila melanogaster

The regulatory architecture of gene expression remains an area of active research. Here, we studied how the interplay of genetic and environmental variation affects gene expression by exposing Drosophila melanogaster strains to four different developmental temperatures. At 18°C we observed almost complete canalization with only very few allelic effects on gene expression. In...

Machine Learning Classification of Cirrhotic Patients with and without Minimal Hepatic Encephalopathy Based on Regional Homogeneity of Intrinsic Brain Activity

Machine learning-based approaches play an important role in examining functional magnetic resonance imaging (fMRI) data in a multivariate manner and extracting features predictive of group membership. This study was performed to assess the potential for measuring brain intrinsic activity to identify minimal hepatic encephalopathy (MHE) in cirrhotic patients, using the support...

Local and distant trauma after hypervelocity ballistic impact to the pig hind limb

The development of high-energy weapons could increase the velocity of projectiles to well over 1000 m/s. The nature of the injuries caused by the ballistic impact of projectiles at velocities much faster than 1000 m/s is unclear. This study characterizes the mechanical and biochemical alterations caused by high-speed ballistic impact generated by spherical steel ball to the hind...

Association between pre-miR-27a functional polymorphism and risk of colorectal cancer in north Chinese Han population

Association between pre-miR-27a functional polymorphism and risk of colorectal cancer in north Chinese Han population Quan Bian,1,* Jian-Jun Chen,2,* Jun-Ping Gu,1 Jing Xu3 1Department of General

Synthesis and Cytotoxicity Evaluation of Tropinone Derivatives

-Jun Chen 0 1 2 0 C.-A. Geng T.-H. Yang T.-Z. Li X.-M. Zhang J.-J. Chen Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201

Molybdenum Nanoscrews: A Novel Non-coinage-Metal Substrate for Surface-Enhanced Raman Scattering

For the first time, Mo nanoscrew was cultivated as a novel non-coinage-metal substrate for surface-enhanced Raman scattering (SERS). It was found that the nanoscrew is composed of many small screw threads stacking along its length direction with small separations. Under external light excitation, strong electromagnetic coupling was initiated within the gaps, and many hot-spots...

Serological Response Predicts Normalization of Cerebrospinal Fluid Abnormalities at Six Months after Treatment in HIV-Negative Neurosyphilis Patients

Province, ChinaYao Xiao, Man-Li Tong, Li-Rong Lin, Li-Li Liu, Kun Gao, Mei-Jun Chen, Hui-Lin Zhang, Wei-Hong Zheng, Tian-Ci Yang & Jian-Jun NiuXiamen Hospital of Traditional Chinese Medicine, Xiamen, Fujian ... Mei-Jun Chen in:Nature Research journals • PubMed • Google Scholar Search for Hui-Lin Zhang in:Nature Research journals • PubMed • Google Scholar Search for Wei-Hong Zheng in:Nature Research journals

Diagnostic performance analysis for diabetic cardiovascular autonomic neuropathy based on short-term heart rate variability using Bayesian methods: preliminary analysis

Objectives This study aimed to estimate the performance of diabetic cardiovascular autonomic neuropathy (DCAN) diagnostic tests in the absence of a gold standard. Background The DCAN prevalence is rapidly growing in all populations worldwide. No document has been reported about diagnostic performance for DCAN based on short-term HRV without a gold standard. Methods We conducted a...

Comparison of tripterygium wilfordii multiglycosides and tacrolimus in the treatment of idiopathic membranous nephropathy: a prospective cohort study

Li 0 Heng Li Qian Liang Jun Chen Jianghua Chen 0 Equal contributors Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University , 79 Qingchun Road, Hangzhou 310003

Liver-Enriched Gene 1, a Glycosylated Secretory Protein, Binds to FGFR and Mediates an Anti-stress Pathway to Protect Liver Development in Zebrafish

Unlike mammals and birds, teleost fish undergo external embryogenesis, and therefore their embryos are constantly challenged by stresses from their living environment. These stresses, when becoming too harsh, will cause arrest of cell proliferation, abnormal cell death or senescence. Such organisms have to evolve a sophisticated anti-stress mechanism to protect the process of...

Identification of Factors for the Preoperative Prediction of Tumour Subtype and Prognosis in Patients with T1 Lung Adenocarcinoma

-lin Tan,2,3 Zhao-yu Wang,2 Zhi-jun Chen,2,3 and Han-bo Le2,3 1Laboratory of Cytobiology and Molecular Biology, Zhoushan Hospital of Wenzhou Medical University, Zhoushan, Zhejiang 316021, China 2Lung ... Science and Technology Bureau of Zhoushan (nos. 2011C12039, 2011C12040, and 2014C31063) to Yong-Kui Zhang, Wang-Yu Zhu, and Zhi-jun Chen; the Medical Bureau of Zhejiang Province (nos. 2015ZDA032, 2016RCB020

Seasonal phoresy as an overwintering strategy of a phytophagous mite

Xu & Jun Chen AuthorsSearch for Sai Liu in:Nature Research journals • PubMed • Google ScholarSearch for Jianling Li in:Nature Research journals • PubMed • Google ScholarSearch for Kun Guo in:Nature ... Jianmin Chen in:Nature Research journals • PubMed • Google ScholarSearch for Changqing Xu in:Nature Research journals • PubMed • Google ScholarSearch for Jun Chen in:Nature Research journals • PubMed

The epidemic characteristics of short stature in school students

, participated in data analysis, drafted the manuscript and participated in its design and coordination. Yue Liu and Xian-jun Chen participated in the design of the study and performed the data acquisition. Li-qi

Improved Robust Filtering Approach for Nonlinear Systems

, Jiangnan University, Wuxi 214122, China Received 24 January 2014; Accepted 20 March 2014; Published 27 April 2014 Academic Editor: Shuping He Copyright © 2014 Jun Chen and Haiqiao Sun. This is an open

Improved Robust Filtering Approach for Nonlinear Systems

, Jiangnan University, Wuxi 214122, China Received 24 January 2014; Accepted 20 March 2014; Published 27 April 2014 Academic Editor: Shuping He Copyright © 2014 Jun Chen and Haiqiao Sun. This is an open

Curcumin attenuates high glucose-induced podocyte apoptosis by regulating functional connections between caveolin-1 phosphorylation and ROS

could also be beneficial in the therapy for other complications of DN. Author contribution Li-na SUN, Guang-ju GUAN, and Gang LIU designed the research; Li-na SUN, Xiang-jun CHEN and Xiang-chun LIU ... University, Shandong University, Ji-nan 250033, ChinaLi-na Sun, Xiang-chun Liu, Guang-ju Guan & Gang LiuChinese Medicine Hospital of Linyi City, Linyi 273400, ChinaXiang-jun Chen AuthorsSearch for Li-na Sun

Dental caries is negatively correlated with body mass index among 7-9 years old children in Guangzhou, China

Background Evidence linking caries in primary dentition and children’s anthropometric measures is contradictory. We aimed to evaluate the prevalence of primary dental caries and its relationship with body mass index (BMI) among 7-9 years old school children in urban Guangzhou, China. Methods This cross-sectional study enrolled 32,461 pupils (14,778 girls and 17,683 boys) aged 7-9...

Lung ultrasonography for the diagnosis of 11 patients with acute respiratory distress syndrome due to bird flu H7N9 infection

Ying Zhan Jun Chen 0 Equal contributors Intensive Care Unit of the Department of Anesthesiology, The First Hospital Affiliated to Suzhou University , Suzhou 215006, Jiangsu , China Background: A novel ... where H7N9 infection is emergent in humans. Authors’ contributions Yu-kun Zhang, Jian Li, and Jun Chen designed the study and co-wrote the manuscript. Yu-kun Zhang, Jian Li, Jian-ping Yang, and Ying Zhan

Numerical and Experimental Investigation on Parameter Identification of Time-Varying Dynamical System Using Hilbert Transform and Empirical Mode Decomposition

Received 21 November 2013; Accepted 3 February 2014; Published 7 April 2014 Academic Editor: Hua-Peng Chen Copyright © 2014 Jun Chen and Guanyu Zhao. This is an open access article distributed under the ... . Acknowledgment Financial support to this paper from the Project of National Key Technology R&D Program in the 12th Five Year Plan of China (2012BAJ03B02) to Jun Chen is appreciated. References A. W. Smyth, S

Effect of Acarbose on Long-Term Prognosis in Acute Coronary Syndromes Patients with Newly Diagnosed Impaired Glucose Tolerance

Objective. To investigate the effect of acarbose therapy on the long-term prognosis of patients with acute coronary syndromes (ACS) complicating newly diagnosed impaired glucose tolerance (IGT). Methodology. 135 patients hospitalized for ACS who had been newly diagnosed with IGT were randomly assigned to acarbose group (150 mg/day, ) or control group (no acarbose, ). All cases in...