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Vertebral artery terminating in posterior inferior cerebellar artery: A normal variation with clinical significance

A vertebral artery (VA) terminating in a posterior inferior cerebellar artery (PICA) is often considered to be a normal variation associated with VA hypoplasia. We aimed to investigate the clinical significance of this cerebrovascular variant. A total of 80 patients with clinically evident cerebrovascular events in posterior circulation were examined by duplex sonography and...

2-O-Methylmagnolol upregulates the long non-coding RNA, GAS5, and enhances apoptosis in skin cancer cells

-Wen Liu Tzu-Chien V. Wang Chi-Yuan Chen Magnolol, a hydroxylated biphenol compound isolated from the bark of Magnolia officinalis, has been shown to exhibit antiproliferative effect in various cancer

Characterization of clinical extensively drug-resistant Pseudomonas aeruginosa in the Hunan province of China

Background Pseudomonas aeruginosa strains that are classed as extensively drug resistant (XDR-PA) are resistant to all antibiotics except for one or two classes and are frequently the cause of hard-to-treat infections worldwide. Our study aimed to characterize clinical XDR-PA isolates recovered during 2011–2012 at nine hospitals in the Hunan province of China. Methods Thirty...

Arbuscular mycorrhizal fungi enhance soil carbon sequestration in the coalfields, northwest China

Carbon storage is affected by photosynthesis (Pn) and soil respiration (Rs), which have been studied extensively in natural and agricultural systems. However, the effects of Pn and Rs on carbon storages in the presence of arbuscular mycorrhizal fungi (AMF) in coalfields remain unclear. A field experiment was established in 2014 in Shendong coal mining subsidence area. The...

The residue I257 at S4–S5 linker in KCNQ1 determines KCNQ1/KCNE1 channel sensitivity to 1-alkanols

Jiu-ping DING conceived and designed the experiments; Chang XIE, Hao-wen LIU, Na PAN and Jing YAO performed the research, designed the experiments and analyzed the data; Jing YAO, Hao-wen LIU and Jiu ... 20120142120062); Jing YAO was also supported by university fund (No 2042014KF0230). Author information Author notesChang Xie & Hao-wen Liu These authors contributed equally to this work. AffiliationsCollege of

Inhibition of Calcium-Activated Chloride Channel ANO1/TMEM16A Suppresses Tumor Growth and Invasion in Human Lung Cancer

Lung cancer or pulmonary carcinoma is primarily derived from epithelial cells that are thin and line on the alveolar surfaces of the lung for gas exchange. ANO1/TMEM16A, initially identified from airway epithelial cells, is a member of Ca2+-activated Cl- channels (CaCCs) that function to regulate epithelial secretion and cell volume for maintenance of ion and tissue homeostasis...

NEAP/DUSP26 suppresses receptor tyrosine kinases and regulates neuronal development in zebrafish

Expression of neuroendocrine-associated phosphatase (NEAP, also named as dual specificity phosphatase 26, [DUSP26]) is restricted to neuroendocrine tissues. We found that NEAP, but not its phosphatase-defective mutant, suppressed nerve growth factor (NGF) receptor TrkA and fibroblast growth factor receptor 1 (FGFR1) activation in PC12 cells upon NGF stimulation. Conversely...

Electric Field-Controlled Crystallizing CaCO3 Nanostructures from Solution

The role of electric field is investigated in determining the structure, morphology, and crystallographic characteristics of CaCO3 nanostructures crystallized from solution. It is found that the lattice structure and crystalline morphology of CaCO3 can be tailed by the electric field applied to the solution during its crystallization. The calcite structure with cubic-like...

The effects of manganese oxide octahedral molecular sieve chitosan microspheres on sludge bacterial community structures during sewage biological treatment

, Ministry of Education, Wuhan Textile University, Wuhan, 430073, ChinaFei PanEnvironmental Engineering Program, Department of Civil Engineering, Auburn University, Auburn, AL 36849, USAFei Pan, Wen Liu ...  & Dongye ZhaoSchool of Materials Science and Engineering, Wuhan Textile University, Wuhan 430073, ChinaXianze Yin AuthorsSearch for Fei Pan in:Nature Research journals • PubMed • Google ScholarSearch for Wen

Application of Stabilized Nanoparticles for In Situ Remediation of Metal-Contaminated Soil and Groundwater: a Critical Review

. Stabilized nanoparticle; Metal; Immobilization; Adsorption; Soil; Groundwater - Remediation of soil and groundwater contaminated with toxic metals has been a major environmental challenge for decades. Wen ... Liu, Shuting Tian and Xiao Zhao contributed equally to this work. Introduction Among the top-listed metals are lead (Pb), cadmium (Cd), mercury (Hg), chromium (Cr), arsenic (As), and a host of the

Online NIR Analysis and Prediction Model for Synthesis Process of Ethyl 2-Chloropropionate

Online near-infrared spectroscopy was used as a process analysis technique in the synthesis of 2-chloropropionate for the first time. Then, the partial least squares regression (PLSR) quantitative model of the product solution concentration was established and optimized. Correlation coefficient () of partial least squares regression (PLSR) calibration model was 0.9944, and the...

Equivalent Conditions of Generalized Convex Fuzzy Mappings

December 2013; Published 8 January 2014 Academic Editors: T. Allahviranloo, E. Ammar, and G. Bonanno Copyright © 2014 Xue Wen Liu and Dou He. This is an open access article distributed under the Creative

Aggregation of Whey Protein Hydrolysate Using Alcalase 2.4 L

Here, we describe peptide aggregation, which is also known as enzymatic protein resynthesis. Whey protein hydrolysate (WPH) is the starting material for assembling peptides. Analyses of the involved amino acids, intrinsic fluorescence, fluorescence phase diagram, secondary structure, turbidity, and surface hydrophobicity were performed to investigate the reaction process. The...

Heat Shock Factor 1 Mediates Latent HIV Reactivation

HSF1, a conserved heat shock factor, has emerged as a key regulator of mammalian transcription in response to cellular metabolic status and stress. To our knowledge, it is not known whether HSF1 regulates viral transcription, particularly HIV-1 and its latent form. Here we reveal that HSF1 extensively participates in HIV transcription and is critical for HIV latent reactivation...

Pharmacogenomics study on cadherin 2 network with regard to HIV infection and methadone treatment outcome

Heroin dependent patients have a high incidence of HIV infection. In contrast to the gene expression method, we developed a systemic correlation analysis method built upon the results of pharmacogenomics study in a methadone maintenance treatment (MMT) cohort consisting of 344 Taiwanese heroin dependent patients. We identified genetic variants and their encoding proteins that may...

Efficacy and safety of calcineurin inhibitor treatment for IgA nephropathy: a meta-analysis

IgA nephropathy is the most common progressive glomerular disease to end stage renal failure worldwide. Calcineurin inhibitors (CNIs) is a selective immunosuppressant widely used in organ transplantation. The efficacy and safety of calcineurin inhibitors for the treatment of IgA nephropathy remain uncertain. We performed a systematic literature search using the PubMed, Embase...

Quantitative proteomic analysis for novel biomarkers of buccal squamous cell carcinoma arising in background of oral submucous fibrosis

Background In South and Southeast Asian, the majority of buccal squamous cell carcinoma (BSCC) can arise from oral submucous fibrosis (OSF). BSCCs develop in OSF that are often not completely resected, causing local relapse. The aim of our study was to find candidate protein biomarkers to detect OSF and predict prognosis in BSCCs by quantitative proteomics approaches. Methods We...

The chromatin scaffold protein SAFB1 localizes SUMO-1 to the promoters of ribosomal protein genes to facilitate transcription initiation and splicing

, Columbus, OH 43210 , USA 1 Present addresses: Hui-wen Liu, Oregon Health and Science University , Portland, OR 97239 , USA. Xiaoyan Guan, Florida State University , Tallahassee, FL , USA 2 Department of