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JAK-STAT6 Pathway Inhibitors Block Eotaxin-3 Secretion by Epithelial Cells and Fibroblasts from Esophageal Eosinophilia Patients: Promising Agents to Improve Inflammation and Prevent Fibrosis in EoE

Background Although most studies on treatments for eosinophilic esophagitis (EoE) have focused on effects in the epithelium, EoE is a transmural disease. Eosinophils that infiltrate the subepithelial layers of the esophagus lead to fibrosis and the serious complications of EoE, and current therapies have shown minimal effects on this fibrosis. We aimed to elucidate T helper (Th)2...

Nanocomposites with Liquid-Like Multiwalled Carbon Nanotubes Dispersed in Epoxy Resin without Solvent Process

, China Received 25 July 2013; Accepted 2 April 2014; Published 11 June 2014 Academic Editor: Nanda Gopal Sahoo Copyright © 2014 Xi Zhang et al. This is an open access article distributed under the

Nanocomposites with Liquid-Like Multiwalled Carbon Nanotubes Dispersed in Epoxy Resin without Solvent Process

, China Received 25 July 2013; Accepted 2 April 2014; Published 11 June 2014 Academic Editor: Nanda Gopal Sahoo Copyright © 2014 Xi Zhang et al. This is an open access article distributed under the

Clinical Efficacy of Therapy with Recombinant Human Interferon α1b in Hand, Foot, and Mouth Disease with Enterovirus 71 Infection

A rapid expansion of HFMD with enterovirus 71 infection outbreaks has occurred and caused deaths in recent years in China, but no vaccine or antiviral drug is currently available for EV71 infection. This study aims to provide treatment programs for HFMD patients. We conducted a randomized, double-blind, controlled trial and evaluated clinical efficacy of therapy with rHuIFN-α1b...

Effects of Zusanli and Ashi Acupoint Electroacupuncture on Repair of Skeletal Muscle and Neuromuscular Junction in a Rabbit Gastrocnemius Contusion Model

-yun Zhao,4 Qian Shen,5 Shou-yao Liu,6 Qian-wei Xu,7 Qing-xi Zhang,8 and Yun-ting Wang9 1Department of Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China 2College of

Prevalence of Metabolic Syndrome and Its Components among Chinese Professional Athletes of Strength Sports with Different Body Weight Categories

Background There is an increasing concern on cardiometabolic health in young professional athletes at heavy-weight class. Objective Our cross-sectional survey aimed to evaluate the prevalence of metabolic syndrome and clustering of metabolic risk factors in a population of young and active professional athletes of strength sports in China. Methods From July 2006 to December 2008...

Favorable outcome of haploidentical hematopoietic stem cell transplantation in Philadelphia chromosome-positive acute lymphoblastic leukemia: a multicenter study in Southwest China

Background Since the introduction of tyrosine kinase inhibitors (TKIs) into combination chemotherapy regimens, the majority of newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) patients have achieved complete remission (CR). However, without allogeneic hematopoietic stem cell transplantation (HSCT), long-term outcomes in adults remain...

Treatment Outcome of Radiotherapy Alone versus Radiochemotherapy in IE/IIE Extranodal Nasal-Type Natural Killer/T Cell Lymphoma: A Meta-Analysis

Background Previous studies have revealed conflicting findings concerning the efficacy of radiotherapy (RT) and radiochemotherapy (RCT) in IE/IIE extranodal nasal-type natural killer/T cell lymphoma (ENKTL). In this study, we conducted a comprehensive meta-analysis to address this issue. Methods We systematically searched PubMed, Cochrane Central Register of Controlled Trials...

FamAnn: an automated variant annotation pipeline to facilitate target discovery for family-based sequencing studies

Summary: FamAnn is an automated variant annotation pipeline designed for facilitating target discovery for family-based sequencing studies. It can apply a different inheritance pattern or a de novo mutations discovery model to each family and select single nucleotide variants and small insertions and deletions segregating in each family or shared by multiple families. It also...

Epidemiology of norovirus infections among diarrhea outpatients in a diarrhea surveillance system in Shanghai, China: a cross-sectional study

Jiayu Hu 0 Huanyu Wu Jian Li Wenjia Xiao Xi Zhang Zheng'an Yuan Fan Wu 0 Equal contributors Department of Infectious Disease Control and Prevention, Shanghai Municipal Center for Disease Control and

CD44v/CD44s expression patterns are associated with the survival of pancreatic carcinoma patients

Zhonghu Li 0 Kai Chen 0 Peng Jiang Xi Zhang Xiaowu Li Zhihua Li 0 Equal contributors Department of Hepatobiliary Surgery Institute, Southwest Hospital, Third Military Medical University , 30

A Five-Year Prospective Study of Diabetic Retinopathy Progression in Chinese Type 2 Diabetes Patients with “Well-Controlled” Blood Glucose

Purpose To determine the progression rate and risk factors for diabetic retinopathy (DR) in Chinese type 2 diabetic patients who have reached the target hemoglobin A1c (HbA1c) level recommended by the American Diabetes Association. Methods This was a 5-year community-based prospective study. The study population consisted of patients with type 2 diabetes with HbA1c less than 7.0...

EphB2 in the Medial Prefrontal Cortex Regulates Vulnerability to Stress

The ephrin B2 (EphB2) receptor is a tyrosine kinase receptor that is associated with synaptic development and maturation. It has recently been implicated in cognitive deficits and anxiety. However, still unknown is the involvement of EphB2 in the vulnerability to stress. In the present study, we observed decreases in EphB2 levels and their downstream molecules in the medial...

The modulation of nicotinic acetylcholine receptors on the neuronal network oscillations in rat hippocampal CA3 area

Province, Xinxiang Medical University, Henan Province, Henan PR. ChinaYang Wang, Zhan Wang, Jiangang Wang, Yali Wang, Xiaofang Wang, Xi Zhang & Chengbiao LuInstitute of Membrane and System Biology ... journals • PubMed • Google ScholarSearch for Xi Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Jinggui Song in:Nature Research journals • PubMed • Google ScholarSearch for Chengbiao Lu

Renin–angiotensin system blockade for the risk of cancer and death

Wei Ling Min-Hui Zhu Xiao-Xi Zhang Yi Sui Hai-Lu Zhao Introduction: The effects of renin-angiotensin system blockade with angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1

Characterization of Spirometra erinaceieuropaei Plerocercoid Cysteine Protease and Potential Application for Serodiagnosis of Sparganosis

Background Sparganosis is a neglected but important food-borne parasitic zoonosis. Clinical diagnosis of sparganosis is difficult because there are no specific manifestations. ELISA using plerocercoid crude or excretory–secretory (ES) antigens has high sensitivity but has cross-reactions with other helminthiases. The aim of this study was to characterize Spirometra...

Endothelial microparticles are increased in congenital heart diseases and contribute to endothelial dysfunction

Background We previously demonstrated that endothelial microparticles (EMPs) are increased in mitral valve diseases and impair valvular endothelial cell function. Perioperative systemic inflammation is an important risk factor and complication of cardiac surgery. In this study, we investigate whether EMPs increase in congenital heart diseases to promote inflammation and...

Treating Colon Cancer Cells with FK228 Reveals a Link between Histone Lysine Acetylation and Extensive Changes in the Cellular Proteome

Medicine, China (No. XTCX-2015-ZD1). Author information AffiliationsDepartment of Biochemistry and Molecular Biology, Xinxiang Medical University, Xinxiang 453003, Henan, ChinaTian-yun Wang, Xi Zhang, Qiu ... in:Nature Research journals • PubMed • Google ScholarSearch for Xi Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Qiu-li Sun in:Nature Research journals • PubMed • Google ScholarSearch

Rhegmatogenous Retinal Detachment Surgery in Elderly People over 70 Years Old: Visual Acuity, Quality of Life, and Cost-Utility Values

Background and Purpose To evaluate the influence of rhegmatogenous retinal detachment (RRD) surgery on elderly patients in terms of visual acuity, vision-related quality of life and its cost-effectiveness. Methods Elderly patients over 70 years old, who were diagnosed and underwent RRD surgery at Shanghai First People's Hospital, Shanghai Jiao Tong University, China, from January...

Genetic Structure Analysis of Spirometra erinaceieuropaei Isolates from Central and Southern China

Background Sparganosis caused by invasion of the plerocercoid larvae (spargana) of Spirometra erinaceieuropaei have increased in recent years in China. However, the population genetic structure regarding this parasite is still unclear. In this study, we used the sequences of two mitochondrial genes cytochrome b (cytb) and cytochrome c oxidase subunit I (cox1) to analyze genetic...