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Tissue Elasticity Regulated Tumor Gene Expression: Implication for Diagnostic Biomarkers of Primitive Neuroectodermal Tumor

Background The tumor microenvironment consists of both physical and chemical factors. Tissue elasticity is one physical factor contributing to the microenvironment of tumor cells. To test the importance of tissue elasticity in cell culture, primitive neuroectodermal tumor (PNET) stem cells were cultured on soft polyacrylamide (PAA) hydrogel plates that mimics the elasticity of...

Genomic insights into the serine protease gene family and expression profile analysis in the planthopper, Nilaparvata lugens

Background The brown planthopper (Nilaparvata lugens) is one of the most destructive rice plant pests in Asia. N. lugens causes extensive damage to rice by sucking rice phloem sap, which results in hopper burn (complete death of the rice plants). Despite its importance, little is known about the digestion, development and defense mechanisms of this hemimetabolous insect pest. In...

A case report of avian influenza H7N9 killing a young doctor in Shanghai, China

Background The novel avian influenza H7N9 virus has caused severe diseases in humans in eastern China since the spring of 2013. On January 18 th 2014, a doctor working in the emergency department of a hospital in Shanghai died of H7N9 virus infection. To understand possible reasons to explain this world’s first fatal H7N9 case of a health care worker (HCW), we summarize the...

Research on the Comparison Analyses of Three-Phase Discrete and Integrated LC Filters in Three-Phase PV Inverter

In three-phase photovoltaic (PV) system, three-phase filter inductors are important part for the output electrical power quality. The comparison analyses of three-phase discrete filter inductors and two kinds of three-phase integrated filter inductors in three-phase PV inverter are proposed. Firstly, the three-phase PV inverter operation with discrete filter inductors is analyzed...

Joint DOA and multi-pitch estimation based on subspace techniques

In this article, we present a novel method for high-resolution joint direction-of-arrivals (DOA) and multi-pitch estimation based on subspaces decomposed from a spatio-temporal data model. The resulting estimator is termed multi-channel harmonic MUSIC (MC-HMUSIC). It is capable of resolving sources under adverse conditions, unlike traditional methods, for example when multiple...

The 5-Year Onset and Regression of Diabetic Retinopathy in Chinese Type 2 Diabetes Patients

Purpose To determine the rate and risk factors of diabetic retinopathy (DR) onset and regression in Chinese type 2 diabetes mellitus patients. Methods This is a 5-year community-based prospective study. The demographic information, systemic examination results and ophthalmological test results of each participant were collected. The study outcomes were DR incidence, defined as...

Use of a Tn5-based transposon system to create a cost-effective Zymomonas mobilis for ethanol production from lignocelluloses

Background Current methods of ethanol production from lignocelluloses generate a mixture of sugars, primarily glucose and xylose; the fermentation cells are always exposed to stresses like high temperature and low nutritional conditions that affect their growth and productivity. Stress-tolerant strains capable of using both glucose and xylose to produce ethanol with high yield...

The specific and rapid labeling of cell surface proteins with recombinant FKBP-fused fluorescent proteins

China (Grant Nos. 31130065, 31270910, 31370851, 31170818, and 31300612) and the CAS Project (KSCX2-EW-Q-11 and KSCX1-1W-J-3). Xi Zhang, Yongqiang Deng, Hao Chang, Chen Ji, Mingshu Zhang, Jianxin Peng

Renal Kallikrein Activation and Renoprotection after Dual Blockade of Renin-Angiotensin System in Diet-Induced Diabetic Nephropathy

exists. Authors’ Contribution Xia Zou and Xiao-xi Zhang contributed equally to this study. Acknowledgments This work was supported by grants from the Guilin Medical University (KY2011002), Program for

Proton Pump Inhibitors Decrease Eotaxin-3 Expression in the Proximal Esophagus of Children with Esophageal Eosinophilia

Objective Besides reducing gastric acid secretion, proton pump inhibitors (PPIs) suppress Th2-cytokine-stimulated expression of an eosinophil chemoattractant (eotaxin-3) by esophageal epithelial cells through acid-independent, anti-inflammatory mechanisms. To explore acid-inhibitory and acid-independent, anti-inflammatory PPI effects in reducing esophageal eosinophilia, we...

Dendritic Cells Regulate Treg-Th17 Axis in Obstructive Phase of Bile Duct Injury in Murine Biliary Atresia

Several cell types are considered to be effector cells in bile duct injury in rhesus rotavirus (RRV)-induced experimental biliary atresia (BA). Here, we identified an increased T helper 17 (Th17) cell population in a BA mode. By depleting the Th17 cells, the BA symptoms (onset of jaundice, acholic stools and retarded growth) were attenuated and the survival rate was improved...

Genetic Structure Analysis of Spirometra erinaceieuropaei Isolates from Central and Southern China

Background Sparganosis caused by invasion of the plerocercoid larvae (spargana) of Spirometra erinaceieuropaei have increased in recent years in China. However, the population genetic structure regarding this parasite is still unclear. In this study, we used the sequences of two mitochondrial genes cytochrome b (cytb) and cytochrome c oxidase subunit I (cox1) to analyze genetic...

Rhegmatogenous Retinal Detachment Surgery in Elderly People over 70 Years Old: Visual Acuity, Quality of Life, and Cost-Utility Values

Background and Purpose To evaluate the influence of rhegmatogenous retinal detachment (RRD) surgery on elderly patients in terms of visual acuity, vision-related quality of life and its cost-effectiveness. Methods Elderly patients over 70 years old, who were diagnosed and underwent RRD surgery at Shanghai First People's Hospital, Shanghai Jiao Tong University, China, from January...

Endothelial microparticles are increased in congenital heart diseases and contribute to endothelial dysfunction

Background We previously demonstrated that endothelial microparticles (EMPs) are increased in mitral valve diseases and impair valvular endothelial cell function. Perioperative systemic inflammation is an important risk factor and complication of cardiac surgery. In this study, we investigate whether EMPs increase in congenital heart diseases to promote inflammation and...

Treating Colon Cancer Cells with FK228 Reveals a Link between Histone Lysine Acetylation and Extensive Changes in the Cellular Proteome

Medicine, China (No. XTCX-2015-ZD1). Author information AffiliationsDepartment of Biochemistry and Molecular Biology, Xinxiang Medical University, Xinxiang 453003, Henan, ChinaTian-yun Wang, Xi Zhang, Qiu ... in:Nature Research journals • PubMed • Google ScholarSearch for Xi Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Qiu-li Sun in:Nature Research journals • PubMed • Google ScholarSearch

Characterization of Spirometra erinaceieuropaei Plerocercoid Cysteine Protease and Potential Application for Serodiagnosis of Sparganosis

Background Sparganosis is a neglected but important food-borne parasitic zoonosis. Clinical diagnosis of sparganosis is difficult because there are no specific manifestations. ELISA using plerocercoid crude or excretory–secretory (ES) antigens has high sensitivity but has cross-reactions with other helminthiases. The aim of this study was to characterize Spirometra...

Renin–angiotensin system blockade for the risk of cancer and death

Wei Ling Min-Hui Zhu Xiao-Xi Zhang Yi Sui Hai-Lu Zhao Introduction: The effects of renin-angiotensin system blockade with angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1

The modulation of nicotinic acetylcholine receptors on the neuronal network oscillations in rat hippocampal CA3 area

Province, Xinxiang Medical University, Henan Province, Henan PR. ChinaYang Wang, Zhan Wang, Jiangang Wang, Yali Wang, Xiaofang Wang, Xi Zhang & Chengbiao LuInstitute of Membrane and System Biology ... journals • PubMed • Google ScholarSearch for Xi Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Jinggui Song in:Nature Research journals • PubMed • Google ScholarSearch for Chengbiao Lu

EphB2 in the Medial Prefrontal Cortex Regulates Vulnerability to Stress

The ephrin B2 (EphB2) receptor is a tyrosine kinase receptor that is associated with synaptic development and maturation. It has recently been implicated in cognitive deficits and anxiety. However, still unknown is the involvement of EphB2 in the vulnerability to stress. In the present study, we observed decreases in EphB2 levels and their downstream molecules in the medial...