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Genetic and Dietary Determinants of Insulin-Like Growth Factor (IGF)-1 and IGF Binding Protein (BP)-3 Levels among Chinese Women

Background Higher insulin-like growth factor (IGF)-1 and lower IGF binding protein (BP)-3 levels have been associated with higher commoncancer risk, including breast cancer. Dietary factors, genetic polymorphisms, and the combination of both may influence circulating IGF-1 and IGFBP-3 serum concentrations. Methods From September 2011 to July 2012, we collected demographic...

Effect of α-linolenic acid on endoplasmic reticulum stress-mediated apoptosis of palmitic acid lipotoxicity in primary rat hepatocytes

Background Hepatic inflammation and degeneration induced by lipid depositions may be the major cause of nonalcoholic fatty liver disease (NAFLD). In this study, we investigated the effects of saturated and unsaturated fatty acids (FA) on apoptosis in primary rat hepatocytes. Methods The primary rat hepatocytes were treated with palmitic acid and/or α-linolenic acid in vitro. The...

α-Linolenic acid prevents endoplasmic reticulum stress-mediated apoptosis of stearic acid lipotoxicity on primary rat hepatocytes

Aims Lipid accumulation in non-adipose tissues leads to cell dysfunction and apoptosis, a phenomenon known as lipotoxicity. Unsaturated fatty acids may offset the lipotoxicity associated with saturated fatty acids. Stearic acid induced endoplasmic reticulum (ER) stress and caused apoptotic and necrotic cell death in the primary rat hepatocytes. Methods Cell viability was...

Blood Neutrophil to Lymphocyte Ratio as a Predictor of Hypertension

Hypertension is a significant global public health challenge. Low-grade inflammation is known to facilitate the development of essential hypertension and target-organ hypertensive damage. Neutrophil to lymphocyte ratio (NLR) is a simple and reliable indicator of inflammation that may also be useful in the prediction of hypertension.

Support vector machine prediction of enzyme function with conjoint triad feature and hierarchical context

Background Enzymes are known as the largest class of proteins and their functions are usually annotated by the Enzyme Commission (EC), which uses a hierarchy structure, i.e., four numbers separated by periods, to classify the function of enzymes. Automatically categorizing enzyme into the EC hierarchy is crucial to understand its specific molecular mechanism. Results In this...

Impact of Admission Glycemic Variability, Glucose, and Glycosylated Hemoglobin on Major Adverse Cardiac Events After Acute Myocardial Infarction

GONG SU PHD SHU-HUA MI HONG TAO PHD ZHAO LI HONG-XIA YANG HONG ZHENG YUN ZHOU LEI TIAN C a r d i o v a s c u l a r a n d OBJECTIVEdDysglycemia is associated with poorer prognosis in patients with

Acceptability and Correlates of Primary and Secondary Prevention of Cervical Cancer among Medical Students in Southwest China: Implications for Cancer Education

Objectives To understand knowledge about, and acceptability of, cervical cancer screening and HPV vaccines among medical students; and to explore potential factors that influence their acceptability in China. Methods We conducted a survey among medical students at six universities across southwest China using a 58-item questionnaire regarding knowledge and perceptions of HPV...

Angiotensin II induces extracellular matrix metalloproteinase inducer expression via an AT1R dependent pathway in aortic atherosclerotic plaque in apolipoprotein E knockout mice

The pathogenesis of acute coronary syndrome is rupture of vulnerable plaque. Extracellular matrix metalloproteinase inducer (EMMPRIN) is reported to have a important role in the destabilization of atheroma. Objectives: this investigation examined the effect of angiotensin II (Ang II) on EMMPRIN expression in atherosclerotic plaques in ApoE knockout mice. Methods: ApoE knockout...

Iterative Algorithms Approach to Variational Inequalities and Fixed Point Problems

We consider a general variational inequality and fixed point problem, which is to find a point x* with the property that (GVF): x*∈GVI(C,A) and g(x*)∈Fix(S) where GVI(C,A) is the solution set of some variational inequality Fix(S) is the fixed points set of nonexpansive mapping S, and g is a nonlinear operator. Assume the solution set Ω of (GVF) is nonempty. For solving (GVF), we...

Clinical and experimental studies regarding the expression and diagnostic value of carcinoembryonic antigen-related cell adhesion molecule 1 in non-small-cell lung cancer

Background Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a multifunctional Ig-like cell adhesion molecule that has a wide range of biological functions. According to previous reports, serum CEACAM1 is dysregulated in different malignant tumours and associated with tumour progression. However, the serum CEACAM1 expression in non-small-cell lung carcinomas...

Genetic variation analysis of reemerging porcine epidemic diarrhea virus prevailing in central China from 2010 to 2011

Porcine epidemic diarrhea has re-emerged with devastating impact in central China since October 2010. To investigate and analyze the reason of this outbreak, the M and ORF3 genes of 15 porcine epidemic diarrhea viruses (PEDV), which were collected from different areas of central China during October 2010 and December 2011, were amplified by reverse transcriptase polymerase chain...

Etiology and Clinical Characteristics of Influenza-Like Illness (ILI) in Outpatients in Beijing, June 2010 to May 2011

Background Since May 2009, exposure of the population of Beijing, China to pH1N1 has resulted in an increase in respiratory illnesses. Limited information is available on the etiology and clinical characteristics of the influenza-like illness (ILI) that ensued in adults following the pH1N1 pandemic. Methods Clinical and epidemiological data of ILI in adults was collected. A total...

Preparation and characterization of silk fibroin as a biomaterial with potential for drug delivery

research; in addition, Hao Zhang analyzed data and wrote the paper. Xia Yang designed research, analyzed data and wrote the paper. Fang-yin Dai, Hao-hao Zhang and Wei Zhou helped to prepare the materials and

Diagnostic accuracy of dual-source CT angiography and coronary risk stratification

Diagnostic accuracy of dual-source CT angiography and coronary risk stratification Xia Yang1, Lu-yue Gai1, Ping Li1, Yun-dai Chen1, Tao Li2, Li Yang21Departments of Cardiology, 2Radiology, Chinese People’s Liberation Army General Hospital, Beijing, ChinaPurpose: The aim of this study was to evaluate the diagnostic accuracy of dual-source computed tomography (DSCT) in coronary...

HIV-, HCV-, and Co-Infections and Associated Risk Factors among Drug Users in Southwestern China: A Township-Level Ecological Study Incorporating Spatial Regression

Background The human immunodeficiency virus (HIV) and hepatitis C virus (HCV) are major public health problems. Many studies have been performed to investigate the association between demographic and behavioral factors and HIV or HCV infection. However, some of the results of these studies have been in conflict. Methodology/Principal Findings The data of all entrants in the 11...

Integrating Genetic Association, Genetics of Gene Expression, and Single Nucleotide Polymorphism Set Analysis to Identify Susceptibility Loci for Type 2 Diabetes Mellitus

Laboratories, Boston, Massachusetts (Danielle M. Greenawalt); Sage Bionetworks, Seattle, Washington (Solveig K. Sieberts, Hua Zhong, Xia Yang, Justin Guinney); Department of Epidemiology, Harvard School of

Complete chloroplast genome sequence of a tree fern Alsophila spinulosa: insights into evolutionary changes in fern chloroplast genomes

Background Ferns have generally been neglected in studies of chloroplast genomics. Before this study, only one polypod and two basal ferns had their complete chloroplast (cp) genome reported. Tree ferns represent an ancient fern lineage that first occurred in the Late Triassic. In recent phylogenetic analyses, tree ferns were shown to be the sister group of polypods, the most...

Studies on Preparation of Photosensitizer Loaded Magnetic Silica Nanoparticles and Their Anti-Tumor Effects for Targeting Photodynamic Therapy

Huang 0 Xiao-Xia Yang 0 Xing-Ping Zhou 0 0 Z.-L. Chen (&) Y. Sun P. Huang X.-X. Yang X.-P. Zhou (&) Department of Pharmaceutical Science and Technology, College of Chemistry and Biology, Donghua

S100A8 and S100A9 Are Associated with Colorectal Carcinoma Progression and Contribute to Colorectal Carcinoma Cell Survival and Migration via Wnt/β-Catenin Pathway

Background and Objective S100A8 and S100A9, two members of the S100 protein family, have been reported in association with the tumor cell differentiation and tumor progression. Previous study has showed that their expression in stromal cells of colorectal carcinoma (CRC) is associated with tumor size. Here, we investigated the clinical significances of S100A8 and S100A9 in tumor...

Dual Inhibition of Plasminogen Kringle 5 on Angiogenesis and Chemotaxis Suppresses Tumor Metastasis by Targeting HIF-1α Pathway

Yang Zhong-Han Yang Jian-Xing Ma Chun-Kui Shao Guo-Quan Gao Anjali Jain, Cedars-Sinai Medical Center, United States of America We had demonstrated that plasminogen kringle 5 (K5), a potent angiogenic