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Therapeutic effects of human adipose tissue-derived stem cell (hADSC) transplantation on experimental autoimmune encephalomyelitis (EAE) mice

University, Wenzhou 32500, Zhejiang, ChinaJia Li, Ying Chen, Zhibo Chen, Yuanyuan Huang, Dehao Yang, Zhongqian Su, Yiyun Weng, Xiang Li & Xu Zhang AuthorsSearch for Jia Li in:Nature Research journals • PubMed ... Yiyun Weng in:Nature Research journals • PubMed • Google ScholarSearch for Xiang Li in:Nature Research journals • PubMed • Google ScholarSearch for Xu Zhang in:Nature Research journals • PubMed • Google

Benefits of Levothyroxine Replacement Therapy on Nonalcoholic Fatty Liver Disease in Subclinical Hypothyroidism Patients

Objectives. To evaluate the effect of levothyroxine (LT4) replacement therapy on nonalcoholic fatty liver disease (NAFLD) in subclinical hypothyroidism (SCH) patients. Methods. This study was a post hoc analysis of a randomized controlled trial and involved 33 significant and 330 mild SCH patients. All of the significant SCH patients received LT4 supplement. The mild SCH patients...

FastICA peel-off for ECG interference removal from surface EMG

Background Multi-channel recording of surface electromyographyic (EMG) signals is very likely to be contaminated by electrocardiographic (ECG) interference, specifically when the surface electrode is placed on muscles close to the heart. Methods A novel fast independent component analysis (FastICA) based peel-off method is presented to remove ECG interference contaminating multi...

Adaptive Content Management for UGC Video Delivery in Mobile Internet Era

The demand of storing and transferring user generated content (UGC) has been rapidly growing with the popularization of mobile devices equipped with video recording and playback capabilities. As a typical application of software-defined networks/network functions virtualization-based pervasive communications infrastructure, content delivery networks (CDNs) have been widely...

Subgroup J avian leukosis virus infection of chicken dendritic cells induces apoptosis via the aberrant expression of microRNAs

Republic of ChinaDi Liu, Manman Dai, Xu Zhang, Weisheng Cao & Ming LiaoKey Laboratory of Veterinary Vaccine Innovation of the Ministry of Agriculture, Guangzhou, People’s Republic of ChinaDi Liu, Manman Dai ... , Xu Zhang, Weisheng Cao & Ming LiaoSouth China Collaborative Innovation Center for Prevention and Control of Poultry Infectious Diseases and Safety of Poultry Products, Guangzhou, People's Republic of

Relationship between fasting glucose levels and in-hospital mortality in Chinese patients with acute myocardial infarction and diabetes mellitus: a retrospective cohort study

Background Previous studies have demonstrated that elevated admission and fasting glucose (FG) is associated with worse outcomes in patients with acute myocardial infarction (AMI). However, the quantitative relationship between FG levels and in-hospital mortality in patients with AMI remains unknown. The aim of the study is to assess the prevalence of elevated FG levels in...

Stress redistribution in multi-stage hydraulic fracturing of horizontal wells in shales

Multi-stage hydraulic fracturing of horizontal wells is the main stimulation method in recovering gas from tight shale gas reservoirs, and stage spacing determination is one of the key issues in fracturing design. The initiation and propagation of hydraulic fractures will cause stress redistribution and may activate natural fractures in the reservoir. Due to the limitation of the...

Combined Effect of Textured Patterns and Graphene Flake Additives on Tribological Behavior under Boundary Lubrication

A ball-on-plate wear test was employed to investigate the effectiveness of graphene (GP) nanoparticles dispersed in a synthetic-oil-based lubricant in reducing wear. The effect by area ratio of elliptically shaped dimple textures and elevated temperatures were also explored. Pure PAO4 based oil and a mixture of this oil with 0.01 wt% GP were compared as lubricants. At pit area...

Mesenchymal stromal cells inhibit CD25 expression via the mTOR pathway to potentiate T-cell suppression

Mesenchymal stromal cells (MSCs) are known to suppress T-cell activation and proliferation. Several studies have reported that MSCs suppress CD25 expression in T cells. However, the molecular mechanism underlying MSC-mediated suppression of CD25 expression has not been fully examined. Here, we investigated the mTOR pathway, which is involved in CD25 expression in T cells. We...

Synergistic intrafibrillar/extrafibrillar mineralization of collagen scaffolds based on a biomimetic strategy to promote the regeneration of bone defects

Xue Zhong,1 Xu Zhang,1 Changyi Li1 1School of Dentistry, Hospital of Stomatology, Tianjin Medical University, Tianjin, People’s Republic of China; 2Thaibinh University of Medicine and Pharmacy, Thaibinh

Identification and evaluation of resistance to powdery mildew and yellow rust in a wheat mapping population

Deployment of cultivars with genetic resistance is an effective approach to control the diseases of powdery mildew (PM) and yellow rust (YR). Chinese wheat cultivar XK0106 exhibits high levels of resistance to both diseases, while cultivar E07901 has partial, adult plant resistance (APR). The aim of this study was to map resistance loci derived from the two cultivars and analyze...

Exosomes from Human Umbilical Cord Mesenchymal Stem Cells: Identification, Purification, and Biological Characteristics

Our and other groups have discovered that mesenchymal stem cells (MSCs) derived exosomes are a novel therapeutical modality for many diseases. In this study, we summarized a method to extract and purify hucMSCs-exosomes using ultrafiltration and gradient centrifugation in our laboratory and proved that hucMSCs-exosomes prepared according to our procedure were stable and bioactive...

Methamphetamine intoxication in a dog: case report

Background Methamphetamine abuse has undergone a dramatic worldwide increase, and represents a significant and global issue for public health. Incidents of methamphetamine intoxication and death in humans are relatively commonplace. Because of its increasing illicit availability, together with legitimate use in human medicine, accidental or intentional exposure to methamphetamine...

Pathogenic variants screening in seventeen candidate genes on 2p15 for association with ankylosing spondylitis in a Han Chinese population

Objectives Previous studies have found the association between rs10865331 in 2p15 area and ankylosing spondylitis (AS). This study aimed to identify additional functional genetic variants in 2p15 region associated with AS susceptibility. Methods We used next generation sequencing (NGS) in 100 AS cases and 100 healthy controls to screen AS susceptible genetic variants, and...

Regulatory non-coding RNA: new instruments in the orchestration of cell death

Non-coding RNA (ncRNA) comprises a substantial portion of primary transcripts that are generated by genomic transcription, but are not translated into protein. The possible functions of these once considered ‘junk’ molecules have incited considerable interest and new insights have emerged. The two major members of ncRNAs, namely micro RNA (miRNA) and long non-coding RNA (lncRNA...

Homographic Patch Feature Transform: A Robustness Registration for Gastroscopic Surgery

Image registration is a key component of computer assistance in image guided surgery, and it is a challenging topic in endoscopic environments. In this study, we present a method for image registration named Homographic Patch Feature Transform (HPFT) to match gastroscopic images. HPFT can be used for tracking lesions and augmenting reality applications during gastroscopy...

Quantitative and compositional responses of ammonia-oxidizing archaea and bacteria to long-term field fertilization

Waste Utilization and National Engineering Research Center for Organic-based Fertilizers, Department of Plant Nutrition, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, ChinaChao Xue, Xu Zhang ... in:Nature Research journals • PubMed • Google ScholarSearch for Xu Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Chen Zhu in:Nature Research journals • PubMed • Google ScholarSearch

A male pheromone-mediated trade-off between female preferences for genetic compatibility and sexual attractiveness in rats

Introduction Chemosensory signals play a vital role in socio-sexual interactions of rodents. Females rely heavily on chemosensory signals to evaluate genetic similarity and quality of potential mates, but their olfactory preferences for these criteria often conflict in mate choice. Results Using two inbred strains of rats, Brown Norway (BB) and Lewis (LL) and their F1 reciprocal...

Characterization of β-glucosidase from Aspergillus terreus and its application in the hydrolysis of soybean isoflavones

in food and feeds. Compliance with ethics guidelines Feng-ying YAN, Wei XIA, Xiao-xu ZHANG, Sha CHEN, Xin-zheng NIE, and Li-chun QIAN declare that they have no conflict of interest. This article