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Voyage inside the cell: Microsystems and nanoengineering for intracellular measurement and manipulation

Properties of organelles and intracellular structures play important roles in regulating cellular functions, such as gene expression, cell motility and metabolism. The ability to directly interrogate intracellular structures inside a single cell for measurement and manipulation has significant implications in the understanding of subcellular and suborganelle activities...

Human sperm rheotaxis: a passive physical process

A long-standing question in natural reproduction is how mammalian sperm navigate inside female reproductive tract and finally reach the egg cell, or oocyte. Recently, fluid flow was proposed as a long–range guidance cue for sperm navigation. Coitus induces fluid flow from oviduct to uterus, and sperm align themselves against the flow direction and swim upstream, a phenomenon...

Microfluidic Assessment of Frying Oil Degradation

journals • PubMed • Google ScholarSearch for Yu Sun in:Nature Research journals • PubMed • Google Scholar Contributions M.L., S.X., C.R., J.L. and Y.S. conceived and designed the project. M.L., Z.X. and Z.W ... no competing financial interests. Corresponding authors Correspondence to Shaorong Xie or Jun Luo or Yu Sun. Supplementary information PDF files1.Supplementary Information 2.Supplementary

Identification of the Avulsion-Injured Spinal Motoneurons

In laboratory studies, counting the spinal motoneurons that survived axonal injury is a major method to estimate the severity and regenerative capacity of the injured motoneurons after the axonal injury and rehabilitation surgery. However, the typical motoneuron marker, the choline acetyltransferase (ChAT), could not be detected in the injured motoneurons within the first 3–4...

Distribution pattern of left-ventricular myocardial strain analyzed by a cine MRI based deformation registration algorithm in healthy Chinese volunteers

The cine magnetic resonance imaging based technique feature tracking-cardiac magnetic resonance (FT-CMR) is emerging as a novel, simple and robust method to evaluate myocardial strain. We investigated the distribution characteristics of left-ventricular myocardial strain using a novel cine MRI based deformation registration algorithm (DRA) in a cohort of healthy Chinese subjects...

IVT-SAPAS: Low-Input and Rapid Method for Sequencing Alternative Polyadenylation Sites

Gene transcribing with alternative polyadenylation (APA) sites leads to mRNA isoforms, which may encode different proteins or harbor different 3'UTRs. APA plays an important role in regulating gene expression network among various physiological processes, such as development, immune responses and cancer. Several methods of library construction for APA study have been developed to...

Prevalence and Phylogenetic Analysis of Human Bocaviruses 1-4 in Pediatric Patients with Various Infectious Diseases

Objectives Viral infections caused by human bocaviruses 1–4 (HBoV1-4) are more complicated than previously believed. A retrospective, large-scale study was undertaken to explore the prevalence of HBoV1-4 in pediatric patients with various infectious diseases and delineate their phylogenetic characteristics. Methods Clinical samples from four specimen types, including 4,941...

Lateralization of gene expression in the honeybee brain during olfactory learning

In the last decade, it has been demonstrated that brain functional asymmetry occurs not only in vertebrates but also in invertebrates. However, the mechanisms underlying functional asymmetry remain unclear. In the present study, we trained honeybees of the same parentage and age, on the proboscis extension reflex (PER) paradigm with only one antenna in use. The comparisons of...

Predictable Chronic Mild Stress during Adolescence Promotes Fear Memory Extinction in Adulthood

Early-life stress in adolescence has a long-lasting influence on brain function in adulthood, and it is mostly recognized as a predisposing factor for mental illnesses, such as anxiety and posttraumatic stress disorder. Previous studies also indicated that adolescent predictable chronic mild stress (PCMS) in early life promotes resilience to depression- and anxiety-like behaviors...

Local application of rapamycin reduces epidural fibrosis after laminectomy via inhibiting fibroblast proliferation and prompting apoptosis

Background Epidural fibrosis is a common complication after laminectomy. It is associated with intractable lower back pain and additional complications. To date, no study has evaluated whether the local application of rapamycin (RAPA) can inhibit fibroblast proliferation and reduce epidural scar adhesion after laminectomy. The results of the present study showed that the local...

Genetic variants of PPAR-gamma coactivator 1B augment NLRP3-mediated inflammation in gouty arthritis

Ting-Jui Chen 0 4 7 Yu-Sun Chang 5 7 Der-Yuan Chen 6 7 Shuen-Iu Hung 0 7 0 Institute of Pharmacology, Program in Molecular Medicine, School of Medicine, National Yang-Ming University , Taipei 1

Dietary legume consumption reduces risk of colorectal cancer: evidence from a meta-analysis of cohort studies

20130142110017 for Xiaoping Miao and The National Natural Science Foundation of China (NSCF-81222038). Author information Author notesBeibei Zhu & Yu Sun These authors contributed equally to this work ... (Wuhan), and Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaBeibei Zhu, Yu Sun, Rong Zhong

Photoinhibition and photoinhibition-like damage to the photosynthetic apparatus in tobacco leaves induced by pseudomonas syringae pv. Tabaci under light and dark conditions

Background Pseudomonas syringae pv. tabaci (Pst), which is the pathogen responsible for tobacco wildfire disease, has received considerable attention in recent years. The objective of this study was to clarify the responses of photosystem I (PSI) and photosystem II (PSII) to Pst infection in tobacco leaves. Results The net photosynthetic rate (Pn) and carboxylation efficiency (CE...

Reduction of intraarticular adhesion of knee by local application of rapamycin in rabbits via inhibition of fibroblast proliferation and collagen synthesis

Background The formation of intraarticular adhesion is a common complication after total knee arthroplasty or anterior cruciate ligament reconstruction. Previously, little research was reported regarding whether the local application of rapamycin (RAPA) could reduce intraarticular adhesion following knee surgery. In our present study, we determined the therapeutic effect of RAPA...

Reduction of intraarticular adhesion of knee by local application of rapamycin in rabbits via inhibition of fibroblast proliferation and collagen synthesis

Shuai Zhao†1, 2, 3, Yu Sun†2, 3, Xiaolei Li1, 2, 3, Jingcheng Wang1, 2, 3Email author, Lianqi Yan1, 2, 3Email author, Hui Chen2, 3, Daxin Wang1, 2, 3, Jihang Dai2, 3 and Jun He2, 3 †Contributed equally

A C-terminally truncated mouse Best3 splice variant targets and alters the ion balance in lysosome-endosome hybrids and the endoplasmic reticulum

Author notesLichang Wu & Yu Sun These authors contributed equally to this work. AffiliationsDepartment of Animal Sciences and Technology, Qingdao Agricultural University, Qingdao, ChinaLichang Wu, Qingjie ... Pan, Huanqi Liu & Yinchuan LiCollege of Biotechnology, Tianjin University of Science and Technology, Tianjin, ChinaLichang Wu, Yu Sun, Liqiao Ma, Jun Zhu, Baoxia Zhang, Yuyin Li & Aipo Diao

Diagnostic Application of Targeted Next-Generation Sequencing of 80 Genes Associated with Disorders of Sexual Development

Institute for Pediatric Research, Shanghai, 200092, ChinaYanjie Fan, Xia Zhang, Lili Wang, Ruifang Wang, Zhuo Huang, Yu Sun, Jun Ye, Lianshu Han, Wenjuan Qiu, Huiwen Zhang, Lili Liang, Xuefan Gu & Yongguo ... Ruifang Wang in:Nature Research journals • PubMed • Google ScholarSearch for Zhuo Huang in:Nature Research journals • PubMed • Google ScholarSearch for Yu Sun in:Nature Research journals • PubMed • Google

Comorbidity and dementia: A nationwide survey in Taiwan

Background Comorbid medical diseases are highly prevalent in the geriatric population, imposing hardship on healthcare services for demented individuals. Dementia also complicates clinical care for other co-existing medical conditions. This study investigated the comorbidities associated with dementia in the elderly population aged 65 years and over in Taiwan. Methods We...

Recent advances in nanorobotic manipulation inside scanning electron microscopes

ScholarSearch for Jun Luo in:Nature Research journals • PubMed • Google ScholarSearch for Ji Ge in:Nature Research journals • PubMed • Google ScholarSearch for Yu Sun in:Nature Research journals • PubMed • Google ... Scholar Competing interests The authors declare no conflict of interest. Corresponding authors Correspondence to Ji Ge or Yu Sun. Rights and permissions This work is licensed under a Creative Commons

Digital Microfluidic Processing of Mammalian Embryos for Vitrification

Cryopreservation is a key technology in biology and clinical practice. This paper presents a digital microfluidic device that automates sample preparation for mammalian embryo vitrification. Individual micro droplets manipulated on the microfluidic device were used as micro-vessels to transport a single mouse embryo through a complete vitrification procedure. Advantages of this...