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Quantitative evaluation of the immunodeficiency of a mouse strain by tumor engraftments

Wen Bing Xu Yao Yao Duanqing Pei 1 Peng Li 1 0 Equal contributors 1 Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes

IL-21 Modulates Release of Proinflammatory Cytokines in LPS-Stimulated Macrophages through Distinct Signaling Pathways

Xie,1 Bing-run Liu,1 Yang Li,1 Qing-kang Lv,1 Zhi-qiang Li,1 Wen-jing Xue,1 Bing-xu Huang,1 Wei Chen,1 and Ju-xiong Liu1 1College of Veterinary Medicine, Jilin University, Changchun 130062, China

Promoter of a cotton fibre MYB gene functional in trichomes of Arabidopsis and glandular trichomes of tobacco

Cotton fibres are unicellular seed trichomes. Our previous study suggested that the cotton R2R3 MYB transcript factor GaMYB2 is a functional homologue of the Arabidopsis trichome regulator GLABRA1 (GL1). Here, the GaMYB2 promoter activity is reported in cotton (Gossypium hirsutum), tobacco (Nicotiana tabacum), and Arabidopsis plants. A 2062 bp promoter of GaMYB2 was isolated from...

Berberine Radiosensitizes Human Esophageal Cancer Cells by Downregulating Homologous Recombination Repair Protein RAD51

Background Esophageal squamous cell carcinomas (ESCC) have poor prognosis. While combined modality of chemotherapy and radiotherapy increases survival, most patients die within five years. Development of agents that confer cancer cell-specific chemo- and radiosensitivity may improve the therapy of ESCC. We here reported the discovery of berberine as a potent radiosensitizing...

Effect of TGF-β/Smad signaling pathway on lung myofibroblast differentiation

Aim:Myofibroblasts play important roles in the pathogenesis of lung fibrosis. Transforming growth factor (TGF)-β1 has been widely recognized as a key fibrogenic cytokine. The major signaling pathway of TGF-β1 is through cytoplasmic Smad proteins. Our study investigated the role of individual TGF-β1/Smad signal proteins in mediating α-smooth muscle actin (α-SMA) gene expression...

Activation of ERK/CREB pathway in spinal cord contributes to chronic constrictive injury-induced neuropathic pain in rats

Aim:To investigate whether activation and translocation of extracellular signal-regulated kinase (ERK) is involved in the induction and maintenance of neuropathic pain, and effects of activation and translocation of ERK on expression of pCREB and Fos in the chronic neuropathic pain.Methods:Lumbar intrathecal catheters were chronically implanted in male Sprague-Dawley rats. The...

Environmental Factors Contributing to the Spread of H5N1 Avian Influenza in Mainland China

BackgroundSince late 2003, highly pathogenic avian influenza (HPAI) outbreaks caused by infection with H5N1 virus has led to the deaths of millions of poultry and more than 10 thousands of wild birds, and as of 18-March 2008, at least 373 laboratory-confirmed human infections with 236 fatalities, have occurred. The unrestrained worldwide spread of this disease has caused great...

Spatio-Temporal Distribution of Malaria in Yunnan Province, China

The spatio-temporal distribution pattern of malaria in Yunnan Province, China was studied using a geographic information system technique. Both descriptive and temporal scan statistics revealed seasonal fluctuation in malaria incidences in Yunnan Province with only one peak during 1995–2000, and two apparent peaks from 2001 to 2005. Spatial autocorrelation analysis indicated that...

Spatial analysis of hemorrhagic fever with renal syndrome in China

Background Hemorrhagic fever with renal syndrome (HFRS) is endemic in many provinces with high incidence in mainland China, although integrated intervention measures including rodent control, environment management and vaccination have been implemented for over ten years. In this study, we conducted a geographic information system (GIS)-based spatial analysis on distribution of...

Spatial analysis of hemorrhagic fever with renal syndrome in China

Hemorrhagic fever with renal syndrome (HFRS) is endemic in many provinces with high incidence in mainland China, although integrated intervention measures including rodent control, environment management and vaccination have been implemented for over ten years. In this study, we conducted a geographic information system (GIS)-based spatial analysis on distribution of HFRS cases...

Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents

, Steve Williams, Bing Xu & Tao YuDepartment of Psychiatry, Université de Montreal, CHU Ste Justine Hospital, Montréal, Québec, Canada H3C 3J7Patricia J. ConrodDepartment of Cognitive and Clinical ... , Katharina Weiss, Robert Whelan, Steve Williams, Bing Xu, Juliana Yacubian, Tao Yu & Veronika Ziesch AuthorsSearch for Christian Büchel in:Nature Research journals • PubMed • Google ScholarSearch for Jan