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Blocking of stromal interaction molecule 1 expression influence cell proliferation and promote cell apoptosis in vitro and inhibit tumor growth in vivo in head and neck squamous cell carcinoma

Calcium signal plays an important role in a variety of cancer cell metabolism, but knowledge on its role in head and neck squamous cell carcinoma (HNSCC) is limited. Store-operated calcium entry (SOCE) is the principal Ca2+ entry mechanism that maintains calcium concentration and produces calcium signal in non-excitable cells. SOCE is triggered by stromal interaction molecule 1...

Role-playing is an effective instructional strategy for genetic counseling training: an investigation and comparative study

, People's Republic of China 1 Authors' information Xiao-feng Xu, Ph.D. Associate Professor, Department of Medical Genetics, Third Military Medical University , Chongqing 400038 , People's Republic of China 2

Revealing chemical processes and kinetics of drug action within single living cells via plasmonic Raman probes

Better understanding the drug action within cells may extend our knowledge on drug action mechanisms and promote new drugs discovery. Herein, we studied the processes of drug induced chemical changes on proteins and nucleic acids in human breast adenocarcinoma (MCF-7) cells via time-resolved plasmonic-enhanced Raman spectroscopy (PERS) in combination with principal component...

INSAR Flat-earth Phase Removal Approach Based on DEM to Settlement Area

The difficulties of phase unwrapping was increased with the existence of flat-earth phase removal, at the same time, it covered up the real topographical conditions. In order to solve this problem, the paper presented a method of re-flattening. based on DEM to eliminate flat-earth phase, with the interferogram, and then chose some special control points to construct polynomial...

INSAR Flat-earth Phase Removal Approach Based on DEM to Settlement Area

The difficulties of phase unwrapping was increased with the existence of flat-earth phase removal, at the same time, it covered up the real topographical conditions. In order to solve this problem, the paper presented a method of re-flattening. based on DEM to eliminate flat-earth phase, with the interferogram, and then chose some special control points to construct polynomial...

Ginsenoside Rg3 Improves Cardiac Function after Myocardial Ischemia/Reperfusion via Attenuating Apoptosis and Inflammation

Objectives. Ginsenoside Rg3 is one of the ginsenosides which are the main constituents isolated from Panax ginseng. Previous study demonstrated that ginsenoside Rg3 had a protective effect against myocardial ischemia/reperfusion- (I/R-) induced injury. Objective. This study was designed to evaluate the effect of ginsenoside Rg3 on cardiac function impairment induced by myocardial...

Influence of Ammonium Zirconium Carbonate on Properties of Poly(vinyl alcohol)/Xylan Composite Films

Academic Editor: Ilaria Armentano Copyright © 2015 Xiao-feng Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use

Minimum-Energy Multiwavelet Frame on the Interval

Drawing inspiration from the idea of combining multiwavelets on the interval with frame theory organically, we study minimum-energy multiwavelet frame on the interval (MEMWFI). Firstly, left boundary multiscaling functions, right boundary multiscaling functions, and the definition of MEMWFI are put forward, and the equivalent characterizations of MEMWFI are given. Then, two...

Starvation at birth impairs germ cell cyst breakdown and increases autophagy and apoptosis in mouse oocytes

The female reproductive lifespan is largely determined by the size of primordial follicle pool, which is established following germ cell cyst breakdown around birth. Almost two-third of oocytes are lost during germ cell cysts breakdown, following autophagic and apoptosis mechanisms. To investigate a possible relationship between germ cell cyst breakdown and nutrition supply, we...

Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone

The global spread of Zika virus (ZIKV) and its unexpected association with congenital defects necessitates the rapid development of a safe and effective vaccine. Here we report the development and characterization of a recombinant chimeric ZIKV vaccine candidate (termed ChinZIKV) that expresses the prM-E proteins of ZIKV using the licensed Japanese encephalitis live-attenuated...

Transplantation of HGF gene-engineered skeletal myoblasts improve infarction recovery in a rat myocardial ischemia model

Background Skeletal myoblast transplantation seems a promising approach for the repair of myocardial infarction (MI). However, the low engraftment efficacy and impaired angiogenic ability limit the clinical efficiency of the myoblasts. Gene engineering with angiogenic growth factors promotes angiogenesis and enhances engraftment of transplanted skeletal myoblasts, leading to...

Two-dimensional artificial light-harvesting antennae with predesigned high-order structure and robust photosensitising activity

Highly ordered discrete assemblies of chlorophylls that are found in natural light-harvesting antennae are key to photosynthesis, which converts light energy to chemical energy and is the principal producer of organic matter on Earth. Porphyrins and phthalocyanines, which are analogues of chlorophylls, exhibit a strong absorbance of visible and near-infrared light, respectively...

Osteopontin regulates macrophage activation and osteoclast formation in hypertensive patients with vascular calcification

Vascular calcification (VC) is a highly regulated ectopic mineral deposition process involving immune cell infiltration in the vasculatures, which has been recognized to be promoted by hypertension. The matricellular glycoprotein osteopontin (OPN) is strongly induced in myeloid cells as a potential inflammatory mediator of vascular injury. This study aims to examine whether OPN...

A Riccati-Bernoulli sub-ODE method for nonlinear partial differential equations and its application

The Riccati-Bernoulli sub-ODE method is firstly proposed to construct exact traveling wave solutions, solitary wave solutions, and peaked wave solutions for nonlinear partial differential equations. A Bäcklund transformation of the Riccati-Bernoulli equation is given. By using a traveling wave transformation and the Riccati-Bernoulli equation, nonlinear partial differential...

Inhibition of Notch 1 receptor influenced the differentiation of Lin-CD45RA-dendritic cell precursors within ovarian carcinoma microenvironment

Background Previous evidence suggested that the differentiation of Lin-CD45RA-DC precursors were prior to plasmcytoid dendritic cells (pDCs) than myeloid dendritic cells (mDCs) within ovarian cancer microenvironment. However, the mechanism is still unclear. Therefore, we investigated the function of Notch 1 signal pathway in the differentiation of Lin-CD45RA-DC precursors...

Influence of artificial grassland restoration on soil carbon pool in an arid mining land

Successful reclamation of degraded mine land can contribute to recuperate the vegetation and soil carbon sequestration. In this study, soil carbon pool was assessed in a mining land after short-term reclamation. We measured above- and belowground biomass and soil carbon storage of artificial grassland (Astragalus adsurgens and Medicago sativa), which was established in the...

MicroRNA-93 Promotes Epithelial–Mesenchymal Transition of Endometrial Carcinoma Cells

MicroRNA-93, derived from a paralog (miR-106b-25) of the miR-17-92 cluster, is involved in the tumorigenesis and progression of many cancers such as breast, colorectal, hepatocellular, lung, ovarian, and pancreatic cancer. However, the role of miR-93 in endometrial carcinoma and the potential molecular mechanisms involved remain unknown. Our results showed that miR-93 was...

Exact solutions and multi-symplectic structure of the generalized KdV-type equation

The homogeneous balance of undetermined coefficients method is proposed to obtain not only exact solutions but also multi-symplectic structure of some nonlinear partial differential equations. Bilinear equation, N-soliton solutions, traveling wave solutions and multi-symplectic structure are obtained by applying the proposed method to the KdV equation. Accordingly, the definition...