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Tea consumption and prostate cancer: an updated meta-analysis

Objectives Tea is supposed to have chemopreventive effect against various cancers. However, the protective role of tea in prostate cancer is still controversial. The aim of this study is to elucidate the association between tea consumption and prostate cancer risk by meta-analysis. Methods A total of 21 published articles were retrieved via both computerized searches and review...

Simultaneous Detection and Differentiation of Human Papillomavirus Genotypes 6, 11, 16 and 18 by AllGlo Quadruplex Quantitative PCR

Background Human papillomaviruses (HPV) are classified into high-risk HPV and low-risk HPV. The most common high-risk HPV types in cervical cancer are HPV 16 and 18, and the most common low-risk types causing genital warts are HPV 6 and HPV 11. In this study, applying novel AllGlo fluorescent probes, we established a quadruplex quantitative PCR method to simultaneously detect and...

Fecal bacterial microbiome diversity in chronic HIV-infected patients in China

The purpose of this study was to identify fecal bacterial microbiome changes in patients with chronic human immunodeficiency virus (HIV) infection in China. Bacterial 16S rRNA genes were amplified, sequenced (454 pyrosequencing), and clustered into operational taxonomic units using the QIIME software. Relative abundance at the phylum and genus levels were calculated. Alpha...

Effects of a selective educational system on fatigue, sleep problems, daytime sleepiness, and depression among senior high school adolescents in Taiwan

Tzeng,1,2,4 Hsin-An Chang,1,2,4 Shin-Chang Kuo,1,2,5 Pei-Yin Pan,1,2 Yi-Wei Yeh,1,2,5 Chin-Bin Yeh,1,2 Wei-Chung Mao1,2,6 1Department of Psychiatry, Tri-Service General Hospital, 2School of Medicine

ERCC1 and ERCC2 Variants Predict Survival in Gastric Cancer Patients

Jaffer A. Ajani 0 Qing-Yi Wei 0 Xiaoping Miao, Tongji Medical College, Huazhong University of Science and Technology, China 0 1 Department of Epidemiology, the University of Texas MD Anderson Cancer

Interleukin-17A Promotes MUC5AC Expression and Goblet Cell Hyperplasia in Nasal Polyps via the Act1-Mediated Pathway

Background Recent studies demonstrated that nasal polyps (NP) patients in China and other Asian regions possessed distinct Th17-dominant inflammation and enhanced tissue remodeling. However, the mechanism underlying these observations is not fully understood. This study sought to evaluate the association of interleukin (IL)-17A with MUC5AC expression and goblet cell hyperplasia...

An Inducible Fusaric Acid Tripartite Efflux Pump Contributes to the Fusaric Acid Resistance in Stenotrophomonas maltophilia

Background Fusaric acid (5-butylpicolinic acid), a mycotoxin, is noxious to some microorganisms. Stenotrophomonas maltophilia displays an intrinsic resistance to fusaric acid. This study aims to elucidate the mechanism responsible for the intrinsic fusaric acid resistance in S. maltophilia. Methodology A putative fusaric acid resistance-involved regulon fuaR-fuaABC was identified...

P Wave Dispersion and Maximum P Wave Duration Are Associated with Renal Outcomes in Chronic Kidney Disease

P wave parameters measured by 12-lead electrocardiogram (ECG) are commonly used as a noninvasive tool to evaluate left atrial enlargement. This study was designed to assess whether P wave parameters were associated with renal outcomes in chronic kidney disease (CKD) patients. This longitudinal study enrolled 439 patients with CKD stages 3–5. Renal end points were defined as the...

Estimating Risk of C. difficile Transmission from PCR Positive but Cytotoxin Negative Cases

Background The use of molecular methods to diagnose Clostridium difficile infection (CDI) has improved diagnostic yield compared to conventional methods. However, PCR testing can detect colonization and has introduced several practical challenges pertaining to need for treatment and isolation of cases. Methods For all new cases detected by real-time PCR, concurrent cytotoxin...

Asymmetric trapping of zwitterionic intermediates by sulphur ylides in a palladium-catalysed decarboxylation-cycloaddition sequence

Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, ChinaTian-Ren Li, Fen Tan, Liang-Qiu Lu, Yi Wei, Ya-Ni Wang, Yi-Yin Liu, Qing-Qing Yang, Jia-Rong Chen, De-Qing Shi & Wen-Jing ... Tan in:Nature Research journals • PubMed • Google ScholarSearch for Liang-Qiu Lu in:Nature Research journals • PubMed • Google ScholarSearch for Yi Wei in:Nature Research journals • PubMed • Google

Quasi-steady-state air plasma channel produced by a femtosecond laser pulse sequence

ScholarSearch for Yu-Tong Li in:Nature Research journals • PubMed • Google ScholarSearch for Li-Ming Chen in:Nature Research journals • PubMed • Google ScholarSearch for Zhi-Yi Wei in:Nature Research journals ... Physics, Chinese Academy of Sciences, Beijing 100190, ChinaXin Lu, Shi-You Chen, Jing-Long Ma, Lei Hou, Guo-Qian Liao, Jin-Guang Wang, Yu-Jing Han, Hao Teng, Hai-Nian Han, Yu-Tong Li, Li-Ming Chen, Zhi-Yi

Silencing of mutant p53 by siRNA induces cell cycle arrest and apoptosis in human bladder cancer cells

Background p53 is the most frequently mutated tumor-suppressor gene in human cancers. It has been reported that mutations in p53 result not only in the loss of its ability as a tumor suppressor, but also in the gain of novel cancer-related functions that contribute to oncogenesis. The present study evaluated the potential of silencing of mutant p53 by small interfering RNA in the...

No Association between TGFB1 Polymorphisms and Late Radiotherapy Toxicity: A Meta-Analysis

BackgroundTransforming growth factor-beta 1 (TGF-β1) protein may be multifunctional and related to the development of fibrosis, induction of apoptosis, extracellular signaling and inhibition of proliferation in response to radiation-induced DNA damage. Several studies have investigated associations between single nucleotide polymorphisms (SNPs) in the TGFB1 gene and risk of late...

Decoy Oligonucleotide Rescues IGF1R Expression from MicroRNA-223 Suppression

A mature miRNA generally suppresses hundreds of mRNA targets. To evaluate the selective effect of synthetic oligonucleotide decoys on hsa-miR-223 activity, reporters containing 3’ untranslated regions (UTR) of IGF1R, FOXO1, POLR3G, FOXO3, CDC27, FBXW7 and PAXIP1 mRNAs were constructed for the luciferase assay. The oligonucleotide decoys were designed and synthesized according to...

Meta-analysis of nonsteroidal anti-inflammatory drug intake and prostate cancer risk

Background Epidemiological studies of the association between nonsteroidal anti-inflammatory drug (NSAID) intake and the risk of prostate cancer still remain controversial. Therefore, we conducted a meta-analysis to evaluate the potential association between NSAID intake and prostate cancer risk. Methods Eligible studies were retrieved by both computerized searches and reviews of...

Meta-analysis of nonsteroidal anti-inflammatory drug intake and prostate cancer risk

Epidemiological studies of the association between nonsteroidal anti-inflammatory drug (NSAID) intake and the risk of prostate cancer still remain controversial. Therefore, we conducted a meta-analysis to evaluate the potential association between NSAID intake and prostate cancer risk. Eligible studies were retrieved by both computerized searches and reviews of references...

MoNetFamily: a web server to infer homologous modules and module–module interaction networks in vertebrates

A module is a fundamental unit forming with highly connected proteins and performs a certain kind of biological functions. Modules and module–module interaction (MMI) network are essential for understanding cellular processes and functions. The MoNetFamily web server can identify the modules, homologous modules (called module family) and MMI networks across multiple species for...

MoNetFamily: a web server to infer homologous modules and module–module interaction networks in vertebrates

A module is a fundamental unit forming with highly connected proteins and performs a certain kind of biological functions. Modules and module–module interaction (MMI) network are essential for understanding cellular processes and functions. The MoNetFamily web server can identify the modules, homologous modules (called module family) and MMI networks across multiple species for...

Intermittent Hypoxia after Transient Focal Ischemia Induces Hippocampal Neurogenesis and c-Fos Expression and Reverses Spatial Memory Deficits in Rats

Background Memory impairment is a frequent complication of brain ischemia. Neurogenesis is implicated in learning and memory and is regulated by the transcription factor c-Fos. Preconditioning intermittent hypoxia (IH) attenuates ischemia-related memory impairments, but it is not known whether post-ischemia IH intervention has a similar effect. We investigated the effects of post...