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High-mobility group box 1 potentiates antineutrophil cytoplasmic antibody-inducing neutrophil extracellular traps formation

Background Recent studies found that the circulating high-mobility group box 1 (HMGB1) levels could reflect the disease activity of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). HMGB1 could prime neutrophils by increasing ANCA antigens translocation for ANCA-mediated respiratory burst and degranulation. The current study aimed to investigate whether...

GhWRKY68 Reduces Resistance to Salt and Drought in Transgenic Nicotiana benthamiana

The WRKY transcription factors modulate numerous physiological processes, including plant growth, development and responses to various environmental stresses. Currently, our understanding of the functions of the majority of the WRKY family members and their possible roles in signalling crosstalk is limited. In particular, very few WRKYs have been identified and characterised from...

Mobility of the first metatarsal-cuneiform joint in patients with and without hallux valgus: in vivo three-dimensional analysis using computerized tomography scan

computerized tomography scan Xiang Geng 0 Chen Wang 0 Xin Ma Xu Wang Jiazhang Huang Chao Zhang Jian Xu Junsheng Yang 0 Equal contributors Department of Orthopedics, Huashan Hospital, Fudan University , 12

Next-generation sequence detects ARAP3 as a novel oncogene in papillary thyroid carcinoma

, Xiao-Hua Zhang, Ou-Chen Wang Department of Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China Purpose: Thyroid cancer is the most frequent

Testicular Busulfan Injection in Mice to Prepare Recipients for Spermatogonial Stem Cell Transplantation Is Safe and Non-Toxic

Current methods of administering busulfan to remove the endogenous germ cells cause hematopoietic toxicity, require special instruments and a narrow transplantation time. We use a direct testicular injection of busulfan method for preparing recipients for SSC transplantation. Male ICR mice (recipients) were divided into four groups, and two experimental groups were treated with a...

Repurposing Blu-ray movie discs as quasi-random nanoimprinting templates for photon management

Society and Northwestern MRSEC (NSF DMR-1121262). We thank Professor S.I. Stupp for letting us use his glove boxes. Author information Author notesAlexander J. Smith & Chen Wang These authors ... University, 2145 Sheridan Road, Evanston, Illinois 60208, USADongning Guo AuthorsSearch for Alexander J. Smith in:Nature Research journals • PubMed • Google ScholarSearch for Chen Wang in:Nature Research

The impacts of network competence, knowledge sharing on service innovation performance: Moderating role of relationship quality

Zhaoquan Jian 0 Chen Wang 0 0 School of Business Administration, South China University of Technology (China) Purpose: To examine how network competence, knowledge sharing and relationship quality affect

Sleep Trajectories of Women Undergoing Elective Cesarean Section: Effects on Body Weight and Psychological Well-Being

Background After cesarean section (CS), women may be at great risk for sleep disturbance, but little is known about temporal changes in their sleep patterns and characteristics. We had two aims: 1) to identify distinct classes of sleep-disturbance trajectories in women considering elective CS from third-trimester pregnancy to 6 months post-CS and 2) to examine associations of...

Rapamycin increases CCN2 expression of lung fibroblasts via phosphoinositide 3-kinase

Excessive production of connective tissue growth factor (CTGF, CCN2) and increased motor ability of the activated fibroblast phenotype contribute to the pathogenesis of idiopathic pulmonary fibrosis (IPF). However, molecules and signal pathways regulating CCN2 expression and migration of lung fibroblasts are still elusive. We hypothesize that rapamycin, via binding and blocking...

Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabine

Background Cancer stem cells (CSCs) are considered responsible for the recurrence and chemoresistance of cancer. Dysregulated autophagy is highly prevalent in many types of cancer including pancreatic cancer and has been implicated in cytoprotection and tumor promotion. This study aimed to investigate the role of autophagy in regulating cancer stemness and chemoresistance of...

An Effective Transform Unit Size Decision Method for High Efficiency Video Coding

May 2014 Academic Editor: Her-Terng Yau Copyright © 2014 Chou-Chen Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted

A panel of four genes accurately differentiates benign from malignant thyroid nodules

Background Clinicians are confronted with an increasing number of patients with thyroid nodules. Reliable preoperative diagnosis of thyroid nodules remains a challenge because of inconclusive cytological examination of fine-needle aspiration biopsies. Although molecular analysis of thyroid tissue has shown promise as a diagnostic tool in recent years, it has not been successfully...

High mobility group box 1 contributes to anti-neutrophil cytoplasmic antibody-induced neutrophils activation through receptor for advanced glycation end products (RAGE) and Toll-like receptor 4

Introduction High mobility group box-1 (HMGB1), a typical damage-associated molecular pattern (DAMP) protein, is associated with inflammatory conditions and tissue damage. Our recent study found that circulating HMGB1 levels could reflect the disease activity of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The current study aimed to investigate whether...

ER Adaptor SCAP Translocates and Recruits IRF3 to Perinuclear Microsome Induced by Cytosolic Microbial DNAs

Stimulator of interferon genes (STING, also known as MITA, ERIS or MPYS) induces the activation of TBK1 kinase and IRF3 transcription factor, upon sensing of microbial DNAs. How IRF3 is recruited onto the STING signalosome remains unknown. We report here that silencing of the ER adaptor SCAP markedly impairs the IRF3-responsive gene expression induced by STING. Scap knockdown...

Decreased deformability of lymphocytes in chronic lymphocytic leukemia

ScholarSearch for John Nguyen in:Nature Research journals • PubMed • Google ScholarSearch for Mark A. Cachia in:Nature Research journals • PubMed • Google ScholarSearch for Chen Wang in:Nature Research journals ... resutls and constructed the manuscript. All authors reviewed the manuscript. Competing interests The authors declare no competing financial interests. Corresponding authors Correspondence to Chen Wang or Yu

Innovative Product Design Based on Comprehensive Customer Requirements of Different Cognitive Levels

To improve customer satisfaction in innovative product design, a topology structure of customer requirements is established and an innovative product approach is proposed. The topology structure provides designers with reasonable guidance to capture the customer requirements comprehensively. With the aid of analytic hierarchy process (AHP), the importance of the customer...

Innovative Product Design Based on Comprehensive Customer Requirements of Different Cognitive Levels

To improve customer satisfaction in innovative product design, a topology structure of customer requirements is established and an innovative product approach is proposed. The topology structure provides designers with reasonable guidance to capture the customer requirements comprehensively. With the aid of analytic hierarchy process (AHP), the importance of the customer...

Urinary Levels of High Mobility Group Box-1 Are Associated with Disease Activity in Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis

Background High mobility group box-1 (HMGB1), a kind of pro-inflammatory mediator, is associated with inflammatory conditions and tissue damage. Our previous study demonstrated that the circulating levels of HMGB1 correlated with disease activity of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). In the current study, we aimed to measure urinary levels of...

A Novel Reaction of Peroxiredoxin 4 towards Substrates in Oxidative Protein Folding

Peroxiredoxin 4 (Prx4) is the only endoplasmic reticulum localized peroxiredoxin. It functions not only to eliminate peroxide but also to promote oxidative protein folding via oxidizing protein disulfide isomerase (PDI). In Prx4-mediated oxidative protein folding we discovered a new reaction that the sulfenic acid form of Prx4 can directly react with thiols in folding substrates...

Vehicle color classification using manifold learning methods from urban surveillance videos

Color identification of vehicles plays a significant role in crime detection. In this study, a novel scheme for the color identification of vehicles is proposed using the locating algorithm of regions of interest (ROIs) as well as the color histogram features from still images. A coarse-to-fine strategy was adopted to efficiently locate the ROIs for various vehicle types. Red...