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Genetic variants in interferon-λ 4 influences HCV clearance in Chinese Han population

Recent many studies indicated a novel dinucleotide variant in ss469415590 (TT vs. ΔG) of interferon-λ 4 (IFNL4) gene strongly associated with hepatitis C virus clearance. To evaluate the impact and clinical usefulness of IFNL4 ss469415590 genotype on predicting both spontaneous HCV clearance and response to therapy in Chinese population, we genotyped 795 chronic HCV carriers, 460...

The Role of a Single Angiogenesis Inhibitor in the Treatment of Recurrent Glioblastoma Multiforme: A Meta-Analysis and Systematic Review

Background Currently, the standard treatment for newly diagnosed glioblastoma multiforme (GBM) is maximal safe surgical resection followed by radiation therapy with concurrent and adjuvant temozolomide. However, disease recurs in almost all patients, and the optimal salvage treatment for recurrent GBM remains unclear. We conducted a systematic review and meta-analysis of...

Polymorphisms in the SP110 and TNF-α Gene and Susceptibility to Pulmonary and Spinal Tuberculosis among Southern Chinese Population

Jiong Li,3 Rong-fu Huang,5 Yan-bing Li,6 Chao-feng Guo,3 Qiang Guo,3 Long-jie Wang,3 Guan-teng Yang,3 and Hong-qi Zhang3 1Department of Laboratory Medicine, The People’s Hospital of Guangxi Autonomous ... -jie Wang, and Rong-fu Huang provided reagents, materials, and technical assistance. Ying Zhou, Jiong Li and Qi-le Gao wrote the paper. Ying Zhou and Chun-yan Tan contributed equally to this work. All

Polymorphisms in the SP110 and TNF-α Gene and Susceptibility to Pulmonary and Spinal Tuberculosis among Southern Chinese Population

Jiong Li,3 Rong-fu Huang,5 Yan-bing Li,6 Chao-feng Guo,3 Qiang Guo,3 Long-jie Wang,3 Guan-teng Yang,3 and Hong-qi Zhang3 1Department of Laboratory Medicine, The People’s Hospital of Guangxi Autonomous ... -jie Wang, and Rong-fu Huang provided reagents, materials, and technical assistance. Ying Zhou, Jiong Li and Qi-le Gao wrote the paper. Ying Zhou and Chun-yan Tan contributed equally to this work. All

Effects of exercise-based cardiac rehabilitation in patients after percutaneous coronary intervention: A meta-analysis of randomized controlled trials

(JDZX2015007). Author information AffiliationsGuang’anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing 100053, ChinaXinyu Yang, Yanda Li, Xingjiang Xiong, Jie Li, Jie Wang & Yanwei XingThe ... • PubMed • Google ScholarSearch for Lijun Wu in:Nature Research journals • PubMed • Google ScholarSearch for Jie Li in:Nature Research journals • PubMed • Google ScholarSearch for Jie Wang in:Nature Research

Giant electrocaloric effect in ferroelectric nanotubes near room temperature

AffiliationsDepartment of Engineering Mechanics, School of Aeronautics and Astronautics, Zhejiang University, Hangzhou 310027, ChinaMan Liu & Jie Wang AuthorsSearch for Man Liu in:Nature Research journals • PubMed ... • Google ScholarSearch for Jie Wang in:Nature Research journals • PubMed • Google Scholar Contributions J.W. conceived and designed the concept. M.L. conducted the simulations. M.L. and J.W. wrote the paper

CRISPR/Cas9-mediated p53 and Pten dual mutation accelerates hepatocarcinogenesis in adult hepatitis B virus transgenic mice

Qi and Zhenzhen Zeng carried out the in vitro and animal experiments. Jie Wang, Ting Zhang, Qiang Xu and Congle Shen carried out the vector design. Lu Wang, Guangde Zhou and Shaomin Yang offered

Vitamin D status and the prevalence of deficiency in lactating women from eight provinces and municipalities in China

Background Vitamin D deficiency has become prevalent worldwide in recent years. However, less evidence was available for lactating women. Objective The purpose of the study was to understand vitamin D status and prevalence of deficiency in lactating women and associated risk factors for vitamin D deficiency from eight provinces and municipalities in China. Methods Lactating women...

Clinical features and viral quasispecies characteristics associated with infection by the hepatitis B virus G145R immune escape mutant

Coexistence of the hepatitis B surface antigen (HBsAg) and hepatitis B surface antibody (anti-HBs) is an uncommon phenomenon, and the underlying mechanisms remain largely unknown. Amino-acid (aa) substitution from glycine to arginine at aa 145 (G145R), in the major hydrophilic region, has been reported in patients with HBsAg and anti-HBs coexistence. However, there is limited...

CD147 promotes cell motility via upregulation of p190-B RhoGAP in hepatocellular carcinoma

Background The acquisition of inappropriate migratory feature is crucial for tumor metastasis. Rho-family GTPases including RhoA are molecular switches that play critical roles in regulating cell movement. We investigated the molecular mechanism underlying CD147 induced RhoA deactivation in hepatocellular carcinoma (HCC) cells. Methods Wound-healing assay was performed to study...

Hybrid weakness in a rice interspecific hybrid is nitrogen-dependent, and accompanied by changes in gene expression at both total transcript level and parental allele partitioning

Background Hybrid weakness, a phenomenon opposite to heterosis, refers to inferior growth and development in a hybrid relative to its pure-line parents. Little attention has been paid to the phenomenological or mechanistic aspect of hybrid weakness, probably due to its rare occurrence. Methodology/Principal findings Here, using a set of interspecific triploid F1 hybrids between...

Effect of Neoadjuvant Chemoradiotherapy on Locally Advanced Rectal Mucinous Adenocarcinoma: A Propensity Score-Matched Study

-bin Xu 0 Sheng-hui Huang 0 Xiao-jie Wang 0 Martin Hubner 0 Department of Colorectal Surgery, Fujian Medical University Union Hospital , Fuzhou, Fujian 350001 , China Aims. To compare the surgical and

Effect of Neoadjuvant Chemoradiotherapy on Locally Advanced Rectal Mucinous Adenocarcinoma: A Propensity Score-Matched Study

, Sheng-hui Huang, and Xiao-jie Wang Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China Correspondence should be addressed to Pan Chi; moc.oohay

Effect of Neoadjuvant Chemoradiotherapy on Locally Advanced Rectal Mucinous Adenocarcinoma: A Propensity Score-Matched Study

, Sheng-hui Huang, and Xiao-jie Wang Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China Correspondence should be addressed to Pan Chi; moc.oohay

Causations of phylogeographic barrier of some rocky shore species along the Chinese coastline

Background Substrate, ocean current and freshwater discharge are recognized as important factors that control the larval dispersal and recruitment of intertidal species. Life history traits of individual species will determine the differential responses to these physical factors, and hence resulting in contrasting phylogeography across the same biogeographic barrier. To determine...

Elevated expression of miR-142-3p is related to the pro-inflammatory function of monocyte-derived dendritic cells in SLE

Background Recent studies have shown that alterations in the function of dendritic cells (DCs) are involved in the pathogenesis of systemic lupus erythematosus (SLE). However, the mechanism of the alteration remains unclear. Methods We cultured monocyte-derived DCs (moDCs) in vitro and examined the cytokines and chemokines in the supernatants of moDCs in negative controls (NC...

Grazoprevir and Elbasvir in Patients with Genotype 1 Hepatitis C Virus Infection: A Comprehensive Efficacy and Safety Analysis

. Yinan Yao, Jie Wang, and Hongbo Chen performed the statistical analysis. Jun Li and Yun Zhang contributed materials and analysis tools. Yinan Yao, Ming Yue, and Peng Huang wrote the paper. All authors

Grazoprevir and Elbasvir in Patients with Genotype 1 Hepatitis C Virus Infection: A Comprehensive Efficacy and Safety Analysis

. Yinan Yao, Jie Wang, and Hongbo Chen performed the statistical analysis. Jun Li and Yun Zhang contributed materials and analysis tools. Yinan Yao, Ming Yue, and Peng Huang wrote the paper. All authors

Induction Chemotherapy Followed by Radiotherapy versus Concurrent Chemoradiotherapy in elderly patients with nasopharyngeal carcinoma: finding from a propensity-matched analysis

Background To date, no guideline is proposed for elderly nasopharyngeal carcinoma (NPC) due to lack of prospective clinical trials. The present study comparing the survivals and toxicities in elderly NPC patients received either induction chemotherapy followed by radiotherapy(IC + RT) or concurrent chemoradiotherapy (CCRT) was therefore undertaken to provide a more accurate basis...

Effectiveness of community-based complementary food supplement (Yingyangbao) distribution in children aged 6-23 months in poor areas in China

Background Poor growth and micronutrient deficiency mainly attack older infants and young children. Some countries have adopted clinically effective measures to combat malnutrition, but the compliance and improvement in efficacy of intervention vehicles in national programs require evaluation. Methods Baseline and follow-up cross-sectional surveys were conducted before and after...