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Apolipoprotein C1 regulates epiboly during gastrulation in zebrafish

Apolipoprotein C1 (Apoc1) is associated with lipoprotein metabolism, but its physiological role during embryogenesis is largely unknown. We reveal a new function of Apoc1b, a transcript isoform of Apoc1, in epiboly during zebrafish gastrulation. Apoc1b is expressed in yolk syncytial layers and in deep cells of the ventral and lateral region of the embryos. It displays a radial...

Coverage, use and maintenance of bed nets and related influence factors in Kachin Special Region II, northeastern Myanmar

Background Myanmar is one of the 31 highest burden malaria countries worldwide. Scaling up the appropriate use of insecticide-treated nets (ITNs) is a national policy for malaria prevention and control. However, the data on use, influencing factors and maintenance of bed nets is still lack among the population in Kachin Special Region II (KR2), Northeastern Myanmar. Methods The...

Enhanced Thermal Stability and Hydrolytic Ability of Bacillus subtilis Aminopeptidase by Removing the Thermal Sensitive Domain in the Non-Catalytic Region

Besides the catalytic ability, many enzymes contain conserved domains to perform some other physiological functions. However, sometimes these conserved domains were unnecessary or even detrimental to the catalytic process for industrial application of the enzymes. In this study, based on homology modeling and molecular dynamics simulations, we found that Bacillus subtilis...

A 3D model for coupling dynamics analysis of high-speed train/track system

A 3D dynamic model of a high-speed train coupled with a flexible ballast track is developed and is presented in this study. In this model, each vehicle is modeled as a 42 degrees of freedom multi-body system, which takes into consideration the nonlinear dynamic characteristics of the suspensions. A detailed inter-vehicle connection model including nonlinear couplers and inter...

Endothelial microparticles are increased in congenital heart diseases and contribute to endothelial dysfunction

Background We previously demonstrated that endothelial microparticles (EMPs) are increased in mitral valve diseases and impair valvular endothelial cell function. Perioperative systemic inflammation is an important risk factor and complication of cardiac surgery. In this study, we investigate whether EMPs increase in congenital heart diseases to promote inflammation and...

Dynamics of Potassium Release and Adsorption on Rice Straw Residue

Straw application can not only increase crop yields, improve soil structure and enrich soil fertility, but can also enhance water and nutrient retention. The aim of this study was to ascertain the relationships between straw decomposition and the release-adsorption processes of K+. This study increases the understanding of the roles played by agricultural crop residues in the...

Ultra-flexible nonvolatile memory based on donor-acceptor diketopyrrolopyrrole polymer blends

Flexible memory cell array based on high mobility donor-acceptor diketopyrrolopyrrole polymer has been demonstrated. The memory cell exhibits low read voltage, high cell-to-cell uniformity and good mechanical flexibility, and has reliable retention and endurance memory performance. The electrical properties of the memory devices are systematically investigated and modeled. Our...

Comparative analysis of human and mouse immunoglobulin variable heavy regions from IMGT/LIGM-DB with IMGT/HighV-QUEST

Wang Peng Wang Li Zhou Xinsheng Yao Background: Immunoglobulin (IG) complementarity determining region (CDR) includes VH CDR1, VH CDR2, VH CDR3, VL CDR1, VL CDR2 and VL CDR3. Of these, VH CDR3 plays a

MiR-1178 Promotes the Proliferation, G1/S Transition, Migration and Invasion of Pancreatic Cancer Cells by Targeting CHIP

CHIP, a co-chaperone protein that interacts with Hsc/Hsp70, has been shown to be under-expressed in pancreatic cancer cells and has demonstrated a potential tumor suppressor property. Nevertheless, the underlying mechanisms of CHIP regulation in pancreatic cancer cells remain unknown. In this study, we found that miR-1178 decreased the translation of the CHIP protein by targeting...

Complete depletion of primordial germ cells in an All-female fish leads to Sex-biased gene expression alteration and sterile All-male occurrence

Li Yang Wang Xi-Yin Li Jian-Xiang Zhong Xiao-Juan Zhang Jun Zhang Li Zhou Jian-Fang Gui 0 Equal contributors State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology

In vitro selection of DNA-cleaving deoxyribozyme with site-specific thymidine excision activity

Single-nucleotide polymorphisms, either inherited or due to spontaneous DNA damage, are associated with numerous diseases. Developing tools for site-specific nucleotide modification may one day provide a way to alter disease polymorphisms. Here, we describe the in vitro selection and characterization of a new deoxyribozyme called F-8, which catalyzes nucleotide excision...

Insulin deficiency induces rat renal mesangial cell dysfunction via activation of IGF-1/IGF-1R pathway

experiments; Jun NI and De-cui SHAO analyzed the data; Nai-jun MIAO and Jin-lan XU contributed the reagents and materials; Ya-li KONG, Li ZHOU, and Hong XUE wrote the manuscript. Ya-li KONG, Xiao-xia WANG and ... AffiliationsDepartment of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai 200032, ChinaYa-li Kong, Yang Shen, Jun Ni, De-cui Shao, Nai-jun Miao, Jin-lan Xu, Li Zhou, Hong Xue, Wei

Design and Analysis of a Novel Compact Wideband Antenna with Two Excited Modes

A novel planar compact wideband antenna with coplanar waveguide (CPW) feeding configuration is presented in this paper. The proposed antenna is fed and coupled by the CPW feeding line at the same time. Therefore, two distinct excited modes are realized. Besides, detail investigation is presented as well to demonstrate the properties of the proposed antenna. Eventually, the...

Novel Compact CPW-Fed Antennas with Harmonic Suppression and Bandwidth Enhancement

Technology, Chengdu 610054, China Received 9 December 2011; Accepted 4 July 2012 Academic Editor: Hala A. Elsadek Copyright © 2012 Zhi-Li Zhou et al. This is an open access article distributed under the

Progress in high-speed train technology around the world

This is a review of high-speed train development in the sense of technology advances all over the world. Three generations of high-speed trains are classified according to their technical characteristics and maximum operating speed. Emphasis is given to the newly developed high-speed train in China, CRH380. The theoretical foundations and future development of CRH380 are briefly...

Why are the neurodegenerative disease-related pathways overrepresented in primary HIV-infected peripheral blood mononuclear cells: a genome-wide perspective

We demonstrate for the first time that the genome-wide profiling of HIV-infected peripheral blood mononuclear cells (PBMCs) from HIV-patients free of neurologic disease show overrepresentation of neurodegenerative pathways (Alzheimer’s, Parkinson’s, ALS, Huntington’s and Prion Disease, etc.) in genome-wide microarray analysis, which suggests that this genome-wide representation...

Expression of c-fos Was Associated with Clinicopathologic Characteristics and Prognosis in Pancreatic Cancer

It has long been regarded that pancreatic cancer (PC) is a life-threatening malignant tumor. Thus, much attention has been paid for factors, especially relative molecules, predictive for prognosis of PC. However, c-fos expression in PC was less investigated. In addition, its association with clinicopathologic variables and prognosis remains unknown. In the present study...

Wnt pathway in atypical teratoid rhabdoid tumors

Background Atypical teratoid rhabdoid tumor (ATRT) is an aggressive pediatric brain tumor with limited therapeutic options. The hypothesis for this study was that the Wnt pathway triggered by the Wnt5B ligand plays an important role in ATRT biology. To address this hypothesis, the role of WNT5B and other Wnt pathway genes was analyzed in ATRT tissues and ATRT primary cell lines.

ProBDNF Signaling Regulates Depression-Like Behaviors in Rodents under Chronic Stress

Chronic exposure to stressful environment is a key risk factor contributing to the development of depression. However, the mechanisms involved in this process are still unclear. Brain-derived neurotropic factor (BDNF) has long been investigated for its positive role in regulation of mood, although the role of its precursor, proBDNF, in regulation of mood is not known. In this...

PPAR Agonist Rosiglitazone Suppresses Renal mPGES-1/PGE2 Pathway in db/db Mice

Evidence had shown the detrimental effect of prostaglandin (PG) E2 in diabetic nephropathy (DN) of STZ-induced type-1 diabetes but its role in the development of DN of type-2 diabetes remains uncertain. The present study was undertaken to investigate the regulation of PGE2 synthetic pathway and the interaction between peroxisome proliferator-activated receptor (PPAR)γ and PGE2...