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Brugia malayi Asparaginyl–Transfer RNA Synthetase Induces Chemotaxis of Human Leukocytes and Activates G-Protein–Coupled Receptors CXCR1 and CXCR2

BackgroundLymphatic filariasis is a chronic human parasitic disease in which the parasites repeatedly provoke acute and chronic inflammatory reactions in the host bloodstream and lymphatics. Excretory-secretory products derived from filariae are believed to play an important role in the development of associated immunologic conditions; however, the specific mechanisms involved in...

Natural Selection and Adaptive Evolution of Leptin in the Ochotona Family Driven by the Cold Environmental Stress

BackgroundEnvironmental stress can accelerate the evolutionary rate of specific stress-response proteins and create new functions specialized for different environments, enhancing an organism's fitness to stressful environments. Pikas (order Lagomorpha), endemic, non-hibernating mammals in the modern Holarctic Region, live in cold regions at either high altitudes or high...

Mitochondrial Uncoupling Protein-2 (UCP2) Mediates Leptin Protection Against MPP+ Toxicity in Neuronal Cells

Mitochondrial dysfunction is involved in the pathogenesis of neurodegenerative diseases, including Parkinson’s disease (PD). Uncoupling proteins (UCPs) delink ATP production from biofuel oxidation in mitochondria to reduce oxidative stress. UCP2 is expressed in brain, and has neuroprotective effects under various toxic insults. We observed induction of UCP2 expression by leptin...

Cloning of the Bacillus thuringiensis serovar sotto chitinase (Schi) gene and characterization of its protein

-Chao FangI; Ping-Zhong CaiII; Wen-Zhao YanII; Jie WuII; Hui-Fang GuoI IJiangsu Academy of Agricultural Sciences, Institute of Plant Protection, Nanjing, Jiangsu Province, China IISichuan Academy of

Negative Regulation of c-Myc Transcription by Pancreas Duodenum Homeobox-1

The pancreatic and duodenal homeobox factor-1 (Pdx1) is essential for pancreatic development and insulin gene transcription, whereas c-Myc has a deleterious effect on islet function. However, the relationship between c-Myc and Pdx1 is poorly concerned. Here we demonstrated that Pdx1 could suppress c-Myc promoter activity, which relied on T cell factor (Tcf) binding elements...

Increased expression of non-sulfated chondroitin correlates with adverse clinicopathological parameters in prostate cancer

. Author information AffiliationsDepartment of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, SingaporeYvonne Hui-Fang Teng, Puay-Hoon Tan, Boon-Huat Bay & George Wai-Cheong ... Yvonne Hui-Fang Teng in:Nature Research journals • PubMed • Google ScholarSearch for Puay-Hoon Tan in:Nature Research journals • PubMed • Google ScholarSearch for Sing-Joo Chia in:Nature Research journals

Pre-clinical Experimental Therapeutics and Pharmacology

, whereas IA plus BBBD should increase the tumor uptake. ET-09. BRAF TARGETED THERAPY IN BRAF V600E MUTANT GLIOBLASTOMA INTRACRANIAL XENOGRAFTS Hui-Fang Li 1, Rintaro Hashizume 2, Yasuyuki Aoki 2, Sujatmi ... INHIBITOR COMBINATION THERAPIES FOR ASSESSING POTENTIAL TREATMENT STRATEGIES FOR NEWLY DIAGNOSED GBM Karine Michaud 1, David A. Solomon 2, Hui-Fang Li 2, Jung-Sik Kim 2, Michael D. Prados 1, Tomoko Ozawa 1