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Epidemiology, genetic epidemiology and Mendelian randomisation: more need than ever to attend to detail

In the current era, with increasing availability of results from genetic association studies, finding genetic instruments for inferring causality in observational epidemiology has become apparently ... . SheehanVanessa Didelez Open Access Original Investigation First Online: 27 May 2019 14 Shares 585 Downloads Part of the following topical collections:Genetic epidemiology of complex diseases

Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity?

(stroke and educational attainment) and provide a more nuanced understanding of population structure, which is set to be revisited as a critical aspect of future analyses in genetic epidemiology. We also ... Downloads Part of the following topical collections:Genetic epidemiology of complex diseases Abstract Replicable genetic association signals have consistently been found through genome-wide association

Epidemiology and screening for renal cancer

PurposeThe widespread use of abdominal imaging has affected the epidemiology of renal cell carcinoma (RCC). Despite this, over 25% of individuals with RCC have evidence of metastases at presentation ... has the potential to downstage the disease. Methods We performed a literature review on the epidemiology of RCC and evidence base regarding screening. Furthermore, contemporary RCC epidemiology data was

Diabetic Gastroparesis: Perspectives From a Patient and Health Care Providers

include botulinum toxin injection into the pylorus, gastric peroral endoscopic myotomy and gastric electrical stimulation. This article provides a detailed review and summary of the epidemiology ... detailed review and summary of the epidemiology, pathophysiology, investigation, and management of diabetic gastroparesis, and also gives an individual patient?s perspective of living with this disabling

The London School of Hygiene and Tropical Medicine: a new century of malaria research

The global malaria situation has scarcely improved in the last 100 years, despite major advances in our knowledge of the basic biology, epidemiology and clinical basis of the disease. Effective ... epidemiology and statistics, tropical nursing, the Diploma in Tropical Medicine and Hygiene and refresher courses in infectious diseases. Research degrees include PhD, DrPH, MPhil and MRes (Master of Science by

From John Snow to omics: the long journey of environmental epidemiology

themselves are usually neither necessary nor sufficient. Epidemiology seems to have reached a limit in disentangling the role of single components in causal complexes, particularly at low doses. To overcome ... societal determinants which are suggested to be the root causes of many non-communicable diseases. Non-communicable disease conditions - Among the heroes of modern epidemiology, John Snow is probably the

Observational studies of treatment effectiveness: worthwhile or worthless?

London, London, UK; 2Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark Abstract: Observational studies which evaluate effectiveness are often viewed with skepticism owing to the fact ... health, University College london , london , UK 1 department of Clinical Epidemiology, Aarhus University , Aarhus, denmark Observational studies which evaluate effectiveness are often viewed with

Genetic and spatial characterization of the red fox (Vulpes vulpes) population in the area stretching between the Eastern and Dinaric Alps and its relationship with rabies and canine distemper dynamics

identified in the study. Knowledge of the regional-scale population structure can improve understanding of the epidemiology and spread of diseases. Our study paves the way for an integrated approach for ... Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe) , Legnaro , Italy , 2 Department of Infectious Disease Epidemiology, Imperial College London , London , United Kingdom , 3

Social justice, epidemiology and health inequalities

important to recognise that epidemiology and public health have a crucial role to play in providing evidence to improve health of society and reduce inequalities. Evidence gives grounds for optimism that ... ‘evidence-based policies’ would pass the epidemiology quality test. An illustration from another scene: the Scottish Parliament. The context: the Health and Sport Committee of the Scottish Parliament taking

International Study of the Epidemiology of Paediatric Trauma: PAPSA Research Study

Objectives Trauma is a significant cause of morbidity and mortality worldwide. The literature on paediatric trauma epidemiology in low- and middle-income countries (LMICs) is limited. This study aims ... prospective cohort study of paediatric trauma admissions, over 1 month, from 15 paediatric surgery centres in 11 countries. Epidemiology, mechanism of injury, injuries sustained, management, morbidity and

Hospital admission with pneumonia and subsequent persistent risk of chronic kidney disease: national cohort study

Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden; 2Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; 3Clinical Epidemiology Unit ... Institutet, Stockholm, Sweden; 4Department of Epidemiology and Public Health, University College, London, UK Background: Although acute onset kidney complications associated with severe infections including

Acute Heart Failure: Definition, Classification and Epidemiology

predominant clinical feature. Management is aimed at treating intercurrent precipitants and encouraging adherence to disease-modifying therapy. Epidemiology of Acute Heart Failure Our knowledge of the ... epidemiology of AHF is informed by a number of large-scale registries conducted in the USA, including ADHERE [ 13 ] and OPTIMIZE-HF [ 14 ], Europe including the European Heart Failure Surveys (EHFS) I [ 15

MC1R variants as melanoma risk factors independent of at-risk phenotypic characteristics: a pooled analysis from the M-SKIP project

Tumori, 2Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy; 3Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden ... , UK 1 Department of Epidemiology, Richard M Fairbanks School of Public Health, Melvin and Bren Simon Cancer Center, Indiana University , Indianapolis, IN , USA 2 School of Epidemiology and Public Health

Features of randomised trials designed by the NPEU Perinatal Trials Service during Adrian Grant’s directorship

Adrian Grant pioneered methodological innovations in the randomised trials organised by the Perinatal Trials Service established at the national Perinatal Epidemiology Unit in Oxford, UK. This ... at the national Perinatal Epidemiology Unit (NPEU). The trials are listed in Appendix 1. Methodological features Appropriate size Our 1984 letter concluded with a warning that, to avoid the dangers

Epidemiology of hip fracture in Belarus: development of a country-specific FRAX model and its comparison to neighboring country models

countries. Differences between the country-specific FRAX patterns and the rank orders of fracture probabilities were modest.ObjectiveThis paper describes the epidemiology of hip fractures in Belarus that was ... Lifecourse Epidemiology Unit, University of Southampton , Southampton , UK 5 Institute for Health and Ageing, Catholic University of Australia , Melbourne , Australia 6 College of Physicians & Surgeons

Clinical epidemiology: A daydream?

never made it-it had disappeared from the clinic, and he concluded with a lament: ''If only Louis had 3 London School of Hygiene and Tropical Medicine , London , UK 4 Department of Clinical Epidemiology ... , Aarhus University Hospital , Aarhus , Denmark 5 Department of Clinical Epidemiology, Leiden University Medical Center , PO Box 9600, 2300 RC Leiden , The Netherlands - succeeded in really commanding the

Linking disease epidemiology and livestock productivity: The case of bovine respiratory disease in France

, Hawkshead Lane, Hatfield, Hertfordshire , United Kingdom , 2 Veterinary Epidemiology and Economics Research Unit, University of Reading , Reading, Berkshire , United Kingdom , 3 Swedish University of

Human cytomegalovirus epidemiology and relationship to tuberculosis and cardiovascular disease risk factors in a rural Ugandan cohort

School of Hygiene and Tropical Medicine, Faculty of Epidemiology and Population Health , London , United Kingdom , 3 Medical Research Council/Uganda Virus Research Institute , Entebbe , Uganda , 4 ... . Epidemiology of cytomegalovirus infections . Rev Infect Dis . 1990 ; 12 : S701± S710 . Available: T=JS&PAGE=reference&D=med1&NEWS=N&AN=214756 PMID: 2173099 2. Cannon MJ

Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics

review compares the clinical characteristics, gross morphology and histopathology, aetiology, epidemiology, and genetics of canine and human OSA. Finally, the current position of canine OSA genetic ... surveillance, epidemiology, evidence and end results (SEER) database in 2004 alone, compared to 3482 cases of OSA in the same database between 1973 and 2004 [ 15, 17 ]. Although OSA is also not very common in

Epidemiology of Sarcopenia: Determinants Throughout the Lifecourse

settings. This review focuses on the epidemiology of the three distinct physiological components of sarcopenia, and highlights the similarities and differences between their patterns of variation with age ... , University of Southampton and University Hospital Southampton NHS Foundation Trust , Southampton SO16 6YD , UK 1 MRC Lifecourse Epidemiology Unit, Southampton General Hospital, University of Southampton