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DNA Ligase 1 is an essential mediator of sister chromatid telomere fusions in G2 cell cycle phase

Fusion of critically short or damaged telomeres is associated with the genomic rearrangements that support malignant transformation. We have demonstrated the fundamental contribution of DNA ligase 4 ... ). Whilst DNA ligase 3 (LIG3) and 4 (LIG4) have long been ascribed functions in non-homologous end-joining (NHEJ) repair (3), LIG1 has conventionally been associated with DNA replication (4–7). During the

Structural insights into chromosome attachment to the nuclear envelope by an inner nuclear membrane protein Bqt4 in fission yeast

The dynamic association of chromosomes with the nuclear envelope (NE) is essential for chromosome maintenance. Schizosaccharomyces pombe inner nuclear membrane protein Bqt4 plays a critical role in ... (SPB) to form a bouquet-like configuration (14,17). The formation of telomere bouquet is critical for efficient pairing and recombination of homologous chromosomes. Upon access into the first meiotic

Chromosome polymorphisms in natural populations of the South American grasshopper Sinipta dalmani

inversion) and in the other chromosomes (M4 inversion). Our results showed that the chromosome polymorphisms in S. dalmani may be associated with a significant decrease in genetic recombination, which may ... exchanges of shorter fragments reducing the efficiency of genetic recombination (Dumas and Britton-Davidian, 2002). In S. dalmani chromosome polymorphisms may be associated with a significant decrease in

Bacterial biofilms with emphasis on coagulase-negative staphylococci

protective environment and favoring the exchange of genetic material between cells as well as intercellular communication. The ability to produce biofilm is observed in a large group of bacteria, including ... the present review was to describe basic and genetic aspects of biofilm formation and methods for its detection, with emphasis on biofilm creation by CNS and its relationship with diseases caused by

RPA resolves conflicting activities of accessory proteins during reconstitution of Dmc1-mediated meiotic recombination

Dmc1 catalyzes homology search and strand exchange during meiotic recombination in budding yeast and many other organisms including humans. Here we reconstitute Dmc1 recombination in vitro using six ... genetic diversity as well as the reciprocal crossover chromosomes required to promote high fidelity reductional chromosome segregation. Meiotic recombination is initiated by the transesterase Spo11 which

Evolution of DNMT2 in drosophilids: Evidence for positive and purifying selection and insights into new protein (pathways) interactions

adenines in DNA. CG16863 CG16863 The protein has zinc finger, BED-type, which is thought to be involved in chromatin insulation at BEAF (boundary element-associated factor) and DREF, a transcriptional ... cytosine-C5 methylation of tRNAs is associated with their structural stability and the rates of protein synthesis in mammals. Cytosine-C5 methylation is involved in protecting tRNA against degradation

Comparative analysis of mutational robustness of the intrinsically disordered viral protein VPg and of its interactor eIF4E

could have a lower impact on the virus fitness. This could favor its exploration of adaptive solutions. The potyviral protein VPg contains IDRs with determinants for adaptation to its host plant. To ... ]. This type of protein possesses loosely packed cores involving secondary structures interspaced with disordered regions [ 35 ]. Viral proteins display a high occurrence of such features. A comparative

Molecular characterization of Histomonas meleagridis exoproteome with emphasis on protease secretion and parasite-bacteria interaction

The exoproteome of parasitic protists constitutes extracellular proteins that play a fundamental role in host-parasite interactions. Lytic factors, especially secreted proteases, are capable of ... CsbD family protein, which were all described to be associated with stress response [ 61?63 ]. As adapted to the in vitro growth, the attenuated H. meleagridis seems to cope more successfully with the

Role of BRCA1-associated protein (BRAP) variant in childhood pulmonary arterial hypertension

PAH in their childhood. Whole-exome next-generation sequencing was performed in the 2 PAH patients and the proband’s healthy mother, and a BRCA1-associated protein (BRAP) gene variant, p.Arg554Leu, was ... 1. Patient disposition. PAH indicates pulmonary arterial hypertension; BMPR2, bone morphogenetic protein receptor type II; ALK1, activin receptor-like kinase 1; ENG, endoglin; CAV1, caveolin-1; KCNK3

Relationship of an hRAD54 gene polymorphism (2290 C/T) in an Ecuadorian population with chronic myelogenous leukemia

The hRAD54 gene is a key member of the RAD52 epistasis group involved in repair of double-strand breaks (DSB) by homologous recombination (HR). Thus, alterations of the normal function of these genes ... cells in order to eliminate deleterious effects is homologous recombination (HR) (Kooistra et al., 1997). HR is generally a precise way of resolving DSB and successful chromosome segregation during

Enterovirus infections and type 1 diabetes mellitus: is there any relationship?

decades, which cannot be explained only by genetic factors. Environmental perturbations have also been associated to the development of diabetes. Among these factors, viral triggers have been implicated ... ; particularly enteroviruses, which have been associated to the induction of the disease. Supporting the hypothesis, numerous lines of evidence coming from mouse models and patients with this type of diabetes have

Structural identification of conserved RNA binding sites in herpesvirus ORF57 homologs: implications for PAN RNA recognition

Kaposi's sarcoma-associated herpesvirus (KSHV) transcribes a long noncoding polyadenylated nuclear (PAN) RNA, which promotes the latent to lytic transition by repressing host genes involved in ... nut1, T1.1) (5,6) and the ORF57/Mta protein (here called ksORF57, to discriminate it from homologous ORF57 proteins found in other herpesviruses) (7–10). PAN RNA accumulates in the nucleus becoming the

Clinical and genetic aspects of familial isolated pituitary adenomas

and genetic features of syndromic disease such as multiple endocrine neoplasia type 1 and Carney complex. Familial isolated pituitary adenoma is inherited in an autosomal dominant manner and accounted ... % of children with macroadenomas. Genetic screening for aryl-hydrocarbon interacting protein gene mutations is warranted in selected high-risk patients who may benefit from early recognition and follow

Creating Hybrid Genes by Homologous Recombination

Recombination of homologous genes is a powerful mechanism for generating sequence diversity, and can be applied to protein analysis and directed evolution. In vitro recombination methods such as DNA ... Disease Markers 0278-0240 Creating hybrid genes by homologous recombination 0 Peter L. Wang Centre for Protein Engineering and Laboratory of Molecular Biology , Hills Road, Cambridge CB2 2QH

Matrix Metalloproteinases in COPD and atherosclerosis with emphasis on the effects of smoking

significant for MMP-1 and-12 after adjusting for traditional risk factors. Conclusion COPD and concomitant plaque in the carotid artery were associated with elevated levels of MMP-1 and -MMP-12 even when ... , Shore AC, Palombo C, Natali A, et al. Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes. Arterioscler

Exploiting a wheat EST database to assess genetic diversity

%) contigs and 96 (10%) singletons were homologous to wheat genes. The database-matched contigs and singletons were assigned to eight functional groups related to protein synthesis, photosynthesis, metabolism ... Research Center, Genetic Engineering and Biotechnology Institute, Gebze-Kocaeli, Turkey IIDepartment of Molecular Biology and Genetics, Istanbul University, Istanbul, Turkey Send correspondence to

Collective radioresistance of T47D breast carcinoma cells is mediated by a Syncytin-1 homologous protein

radiosensitivity of T47D human breast carcinoma cells in tight clusters is different from that of isolated cells. Molecular analyses show that T47D cells express a Syncytin-1 homologous protein (SyHP). We observe ... homologous protein (SyHP). We observe that SyHP translocates to the external surface of the plasma membrane of cells killed by radiation treatment. The data support the fundamental role of SyHP in the

Distribution of N-acetyltransferase Type 1 (NAT1) genotypes and alleles in a Turkish population

NAT1 is an intronless gene on chromosome 8p21.3 encoding a 290-amino-acid-long protein showing acetyltransferase activity. Some 26 alleles of NAT1 gene have been identified in human populations. In ... *11/NAT1*4 (7.46), NAT1*10/NAT1*10 (3.98%). Frequencies of NAT1*3, *4 (wild-type), *10 and *11 alleles were 3.73%, 69.6%, 17.66% and 7.2%, respectively. The frequency of NAT1*11 was the highest amongst

Association of GNAS imprinting defects and deletions of chromosome 2 in two patients: clues explaining phenotypic heterogeneity in pseudohypoparathyroidism type 1B/iPPSD3

features of AHO were described, but no explanation for such phenotypic heterogeneity is available.An AHO-like phenotype was associated with the loss of genetic information stored in chromosome 2q37, making ... changes at one or more GNAS differentially methylated regions (DMRs), associated with or without a genetic (deletion) or cytogenetic (uniparental disomy (UPD)) defect. Pseudohypoparathyroidism type 1B

Restoring pollen fertility in transgenic male-sterile eggplant by Cre/loxp-mediated site-specific recombination system

the Barnase gene were obtained, all proved to be male-sterile and incapable of producing viable pollen. Flowers stamens were shorter, but the vegetative phenotype was similar to wild-type. Five T0 ... seeds. Genetic engineering may offer a new opportunity to introduce nuclear male sterility (NMS) to eggplant. Previous studies of Cre-mediated recombination in plants focused on the removal of