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Can there be science without philosophy?

Over the last few decades, philosophy has gained an increasingly bad reputation among working scientists. Prominent researchers have suggested, in various forms and degrees of mockery, that ... 18th century, these two disciplines were inextricably entangled, and many seminal chapters in the history of science fall under the aegis of ?natural philosophy??Newton?s masterpiece, ?Philosophiae

Caffeine consumption and mortality in chronic kidney disease: a nationally representative analysis

An inverse relationship between coffee consumption and mortality has been reported in the general population. However, the association between caffeine consumption and mortality in patients with ... mortality in patients with chronic kidney disease (CKD) remains uncertain. Methods We analysed 4863 non-institutionalized USA adults with CKD [defined by an estimated glomerular filtration rate (eGFR) of 15

Chronic interstitial nephritis in agricultural communities: a worldwide epidemic with social, occupational and environmental determinants

Increase in the prevalence of chronic kidney disease (CKD) is observed in Central America, Sri Lanka and other tropical countries. It is named chronic interstitial nephritis in agricultural ... ||| characterized renal syndromes [1]. In addition to these 'tradiand dehydration. Existing evidence supports occupational and ||| tional' causes, glomerular and tubulo-interstitial diseases due to environmental

Proteinase-3 and myeloperoxidase serotype in relation to demographic factors and geographic distribution in anti-neutrophil cytoplasmic antibody-associated glomerulonephritis

In anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis, antigen specificity varies between myeloperoxidase (MPO) and proteinase 3 (PR3). This has been reported to vary in ... , with more frequent occurrence in MPA than in GPA and EGPA [4, 5]. The aetiology of AAV is still unknown but is believed to be dependent on both genetic and environmental factors, with no single factor

Cardiovascular disease in the kidney transplant recipient: epidemiology, diagnosis and management strategies

Kidney transplantation (KT) is the optimal therapy for end-stage kidney disease (ESKD), resulting in significant improvement in survival as well as quality of life when compared with maintenance ... maintenance dialysis. The burden of cardiovascular disease (CVD) in ESKD is reduced after KT; however, it still remains the leading cause of premature patient and allograft loss, as well as a source of

Defining AKI: closer to getting the math right

Columbia 2 Université de Montréal, Maisonneuve-Rosemont Hospital Research - In this issue of the journal, Wang et al. describe a novel approach for assessing risk for inpatient mortality using different ... definitions of acute kidney injury (AKI). The authors use absolute changes in serum creatinine (SCr) instead of changes in stages as defined by KDIGO AKI guidelines, and demonstrate that the net

Defining AKI: closer to getting the math right

. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved - Correspondence and offprint requests to: Adeera Levin; Email: In this issue of the journal, Wang et al. describe a novel ... approach for assessing risk for inpatient mortality using different definitions of acute kidney injury (AKI). The authors use absolute changes in serum creatinine (SCr) instead of changes in stages as

Sodium butyrate ameliorates insulin resistance and renal failure in CKD rats by modulating intestinal permeability and mucin expression

The associated increase in the lipopolysaccharide (LPS) levels and uremic toxins in chronic kidney disease (CKD) has shifted the way we focus on intestinal microbiota. This study shows that a ... study shows that a disruption of the intestinal barrier in CKD promotes leakage of LPS from the gut, subsequently decreasing insulin sensitivity. Butyrate treatment improved the intestinal barrier

Causality at the dawn of the ‘omics’ era in medicine and in nephrology

Causality is a core concept in medicine. The quantitative determinacy characterizing today's biomedical science is unprecedented. The assessment of causal relations in human diseases is evolving, and ... the basis of the new precision medicine. causality, dispositionalism, empiricism, Hume, manipulability theory, randomized trial INTRODUCTION Causality, a core concept in the philosophy of science

News from ERA-EDTA: ERA-EDTA Congress in Budapest—Üdvözöljük!

gathers together key European investigators who, each in their respective field of expertise, will present state-of-the-art nephrological research (from basic to clinical science) and will discuss new data ... 2019, in Budapest With more than 10 000 participants, the ERA-EDTA Congress is one of the largest nephrology meetings worldwide and is now becoming more and more international with delegates from all

Renal angiomyolipoma in patients with tuberous sclerosis complex: findings from the TuberOus SClerosis registry to increase disease Awareness

Renal angiomyolipoma occurs at a high frequency in patients with tuberous sclerosis complex (TSC) and is associated with potentially life-threatening complications. Despite this frequency and ... who were newly diagnosed with TSC before participation in the registry were eligible. Data specific to renal angiomyolipoma included physical tumour characteristics (multiple, bilateral, lesion size and

ERA-EDTA invests in transformation to greener health care

degradation of soil constitute major problems for mankind. Respiratory, cardiovascular and kidney diseases, as well as cancer and reproductive and neurodevelopmental diseases, are all in part environmental ... activities. This is in conflict with the general theme in medicine of ?primum non nocere?. While the attention of health professionals, policymakers and politicians to environmental problems in general is on

Monoclonal immunoglobulin G deposits on tubular basement membrane in renal allograft: is this significant for chronic allograft injury?

Tubular basement membrane immune deposits (TBMID) has rarely been observed in renal allografts. It is usually found in BK virus nephropathy and immune complex glomerulonephritis; however, its ... ) deposits of IgG were found in 73 biopsies from 61 patients and the IgG subclass was obtained in 31 biopsies. There were no cases of monoclonal IgA or IgM TBMID. In total, 13 biopsies from 10 patients showed

B-cell therapy in lupus nephritis: an overview

-antigens. B-cells, plasmablasts and plasma cells, as the source of these autoantibodies, play a major role in the development of lupus nephritis (LN), and are therefore promising therapeutic targets. To date ... targets. To date, however, randomized clinical trials of B-cell therapies in LN have not lived up to expectations, whereas uncontrolled cohort and observational studies of B-cell antagonists have been more

TRANSPLANTATION BASIC SCIENCE, ALLOGENIC AND XENOGENIC TOLERANCE

pulse steroid therapy in reducing proteinuria was analysed in kidney transplant recipients R group. Results: Pre-transplantation serum proportion of Gd-IgA1 and IgA-IgG complexes were higher in R group ... or healthy controls (respectively p<0 01 and p<0 001). Both the R and NR groups had increased values of IgA-sCD89 complexes compared to healthy controls, but values were lower in R compared to NR ( p<0

Chronic kidney disease in low- and middle-income countries

Most of the global burden of chronic kidney disease (CKD) is occurring in low- and middle-income countries (LMICs). As a result of rapid urbanization in LMICs, a growing number of populations are ... crowded cities with unplanned infrastructure, poor sanitation and waste disposal and heavy environmental pollution [47]. As a result, a growing number of people live in settings where numerous environmental

TRANSPLANTATION BASIC SCIENCE, ALLOGENIC AND XENOGENIC TOLERANCE

complexes and IgA-sCD89 complexes. Efficacy of pulse steroid therapy in reducing proteinuria was analysed in kidney transplant recipients R group. Results: Pre-transplantation serum proportion of Gd-IgA1 and ... IgA-IgG complexes were higher in R group compared to NR group or healthy controls (respectively p<0 01 and p<0 001). Both the R and NR groups had increased values of IgA-sCD89 complexes compared to

Transplantation: basic science

particles involved in cell-to-cell communication through transfer of proteins and genetic information. The aim of this study was to evaluate the protective role of MSC-derived EVs in the mechanisms of T-cell ... Transplantation and Regenerative Surgery Graduate School of Medical Science, Kyoto Prefectural University of Medicine Kyoto Japan TRANSPLANTATION: BASIC SCIENCE Rebeca Nuñez-Lozano1, Yaremi Quirós1, Penelope

Chronic kidney disease in low- and middle-income countries

Most of the global burden of chronic kidney disease (CKD) is occurring in low- and middle-income countries (LMICs). As a result of rapid urbanization in LMICs, a growing number of populations are ... growing number of people live in settings where numerous environmental toxins, high infectious disease burdens and increasing rates of NCDs, including hypertension and diabetes, are all juxtaposed [ 4, 48

Transplantation: basic science

VESICLES DERIVED FROM MESENCHYMAL STEM CELLS INHIBIT TUBULAR INJURY, T CELL PROLIFERATION AND PROMOTE REGULATORY T CELL DIFFERENTIATION THROUGH TRANSFER OF SPECIFIC RNAs: PROTECTIVE ROLE IN T-CELL ... vesicles (EVs), small particles involved in cell-to-cell communication through transfer of proteins and genetic information. The aim of this study was to evaluate the protective role of MSC-derived EVs in