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Vitamin D binding protein polymorphisms significantly impact vitamin D status in children

BackgroundPolymorphic alleles of the vitamin D (vitD)-binding protein (VDBP) gene are associated with discriminatory differences in circulating concentrations of 25-hydroxyvitamin D (25-D), the ... . Genetic and environmental determinants of 25- hydroxyvitamin D and 1 ,25 -dihydroxyvitamin D levels in Hispanic and African Americans . J. Clin. Endocrinol. Metab . 93 , 3381 - 3388 ( 2008 ). 29. Fu , L. et

Genetic and metabolic predictors of hepatic fat content in a cohort of Italian children with obesity

ObjectivesTo comprehensively explore metabolic and genetic contributors to liver fat accumulation in overweight/obese children.MethodsTwo hundred thirty Italian children with obesity were ... depend on the shorter time of exposure to environmental factors interacting with the GCKR gene variant. In fact, it has been reported that the rs1260326 variant, which encodes for the GCKR P446L protein

Correction: The effect of light wavelength on in vitro bilirubin photodegradation and photoisomer production

of Chemistry and RECETOX, Faculty of Science, Masaryk University , Kamenice 5, 625 00 Brno , Czech Republic Shared first authors: Hendrik J. Vreman, Stephanie Kourula, Jana Jas?prova? - Following ... associated with the ?Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University, Kate?insk? 32, 120 00 Prague, Czech Republic?. This has been corrected in both

The International Neonatal Consortium: collaborating to advance regulatory science for neonates

Institute (C-Path), which has 12 consortia working in a ?precompetitive space? to share data and expertise to advance regulatory science. Close relationships with regulators in the United States, Europe ... laboratory values, and long-term follow-up of outcomes. INVOLVEMENT OF KEY PARTNERS IN NEONATAL REGULATORY SCIENCE INC will develop approaches that integrate neonatal nurses and families, and other

Biological, environmental, and social influences on childhood obesity

The prevalence of childhood obesity has increased globally over the past three decades, with evidence of recent leveling off in developed countries. Reduction in the, currently high, prevalence of ... (35,37,39,40,41,42). In addition, lower obesity levels are observed in areas where the natural environment has high recreational value (43). While evidence suggests that the above environmental factors affect risk

Epigenetics: linking social and environmental exposures to preterm birth

in personal product use, diet, and residential geographical separation. Emerging evidence suggests that environmental exposure to metals and plasticizers contribute to preterm birth and epigenetic ... addressed the role of epigenetics in the pathophysiology of preterm birth. In this review, we highlight a few recent studies that support the plausibility of a role for environmental epigenetics in modifying

Maternal influence on the fetal microbiome in a population-based study of the first-pass meconium

have an effect.ConclusionThe microbiome of the first-pass meconium was not altered by immediate perinatal factors, but was affected by maternal factors during pregnancy, implying the in utero transfer of ... environmental exposures during pregnancy and delivery. Methods Study Design and Population For this population-based study, we recruited consecutive newborn infants born in Central Finland Central Hospital in

Neonatal resuscitation in global health settings: an examination of the past to prepare for the future

landscape. A brief situational analysis of asphyxia-related newborn mortality in low-resource settings is linked to renewed efforts to reduce neonatal mortality in the Every Newborn Action Plan. Possible ... global landscape of neonatal resuscitation that have been driven by evaluation of evidence around resuscitation science, training in neonatal resuscitation, and implementation of programs focusing on care

Surfactant replacement therapy for respiratory distress syndrome in preterm infants: United Kingdom national consensus

Kingdom (UK) neonatal specialists on the use of surfactant for the management of respiratory distress syndrome RDS in preterm infants. RDS due to surfactant deficiency is common in preterm infants. Signs ... , including tachypnoea, recessions, and grunting, usually commence shortly after birth, and increase in severity during the first 12?48 h of postnatal life. Significant RDS may require mechanical ventilation

Estimation of adult and neonatal RBC lifespans in anemic neonates using RBCs labeled at several discrete biotin densities

vs. allogeneic adult RBCs performed concurrently in the same infant. Biotin labeling of autologous neonatal RBCs and allogeneic adult donor RBCs permits concurrent direct comparison of autologous vs ... survive for longer than they would have in the infant donor ( 7 ), suggesting that environmental circulatory conditions may play a major and unappreciated role in relative RBC survival. The most commonly

Glucocorticoid receptor expression on circulating leukocytes in healthy and asthmatic adolescents in response to exercise

prospective exercise training intervention of healthy and asthmatic adolescents, GR expression in leukocytes was measured using flow cytometry in response to an acute exercise challenge before and after the ... neutrophils . J Appl Physiol 2008 ; 104 : 236 - 43 . 12. Cooper DM , Kaplan M , Baumgarten L , Weiler-Ravell D , Whipp BJ , Wasserman K. Coupling of ventilation and CO_2_ production during exercise in children

Risk factors of different congenital heart defects in Guangdong, China

environmental exposures, including living in newly renovated rooms, residential proximity to main traffic, paternal smoking, and maternal occupation as manual worker, were significantly associated with CHDs with ... General Hospital (Guangdong Academic of Medical Science) , Guangzhou, Guangdong , China Background: Limited studies have evaluated the risk factors for congenital heart defects (CHDs) in China and compared

Emerging science of hydroxyurea therapy for pediatric sickle cell disease

Hydroxyurea (HU) is the sole approved pharmacological therapy for sickle cell disease (SCD). Higher levels of fetal hemoglobin (HbF) diminish deoxygenated sickle globin polymerization in vitro and ... these questions from a translational science perspective. SCD affects an estimated 90,000 people in the United States ( 2 ), with more than 1,900 newborns detected annually through universal newborn

Useful pharmacodynamic endpoints in children: selection, measurement, and next steps

Pharmacodynamic (PD) endpoints are essential for establishing the benefit-to-risk ratio for therapeutic interventions in children and neonates. This article discusses the selection of an appropriate ... endpoint, which is a critical methodological step in designing pediatric efficacy and safety studies. We provide an overview of existing guidance on the choice of PD endpoints in pediatric clinical research

Association between breastfeeding duration and cognitive development, autistic traits and ADHD symptoms: a multicenter study in Spain

association of breastfeeding with cognitive function apart from socio-environmental factors, and also suggests a protective role against autistic traits. Results are in agreement with recommendations for ... cognition beyond parental and socio-environmental factors ( 3?6 ). Inconsistent assessment of breastfeeding duration and intensity, and variability in the tasks used to assess child intelligence, may have

Application of NPE in the assessment of a patent ductus arteriosus

In many preterm infants, the ductus arteriosus remains patent beyond the first few days of life. This prolonged patency is associated with numerous adverse outcomes, but the extent to which these ... outcomes, with a paucity of data on the correct diagnostic and pathophysiological assessment of the patent ductus arteriosus (PDA) in association with long-term outcomes. Echocardiography is the selected

Parent, child and public involvement in child health research: core value not just an optional extra

informed and give their opinion about the world around them1. Here we discuss PatientPublic Involvement (PPI) in research and why it is important and provide a framework to assist healthcare professionals ... . WHAT IS PPI Patients? and public involvement (PPI) ( means involving anyone not professionally interested or experienced in health and care in in

Understanding the role of gut microbiome in metabolic disease risk

between predisposing genetic and environmental factors. Animal studies show that gut microbiota and its genome (microbiome) influence alterations in energy balance (increased energy harvest) and immunity ... seem to be highly specific for each individual, resulting in large interindividual variations that depend on both host genetics and environmental factors ( 1,2 ). This specificity has hindered our

The role of social determinants in explaining racial/ethnic disparities in perinatal outcomes

insights into this subject, including adding social determinant data to population-based datasets; exploring multiple constructs in their analysis; and examining environmental factors. The objective of this ... multiple social constructs in these observed disparities; or account for physical and environmental factors in racial/ethnic differences in outcomes. The objective of this review is to examine this recent

Prenatal exposure to bisphenol A and risk of allergic diseases in early life

Background:Prenatal exposure to bisphenol A (BPA) affects immune system and promotes allergy and asthma in mice, but findings in human studies are limited. We investigated whether prenatal exposure ... , Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology