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Computational methods and applications for quantitative systems pharmacology

BackgroundQuantitative systems pharmacology (QSP) is an emerging discipline that integrates diverse data to quantitatively explore the interactions between drugs and multi-scale systems including ... , molecular modeling, logical modeling, network modeling, pathway analysis, multi-scale systems pharmacology platforms and virtual patient for QSP have been developed. We reviewed the major progresses and broad

Bougainvillea Genus: A Review on Phytochemistry, Pharmacology, and Toxicology

of Pharmacy and Pharmacology, vol. 3, no. 5, pp. 185–190, 2009. View at Google Scholar · View at ScopusN. Mishra and V. L. Tandon, “Haematological effects of aqueous extract of ornamental plants in

Bougainvillea Genus: A Review on Phytochemistry, Pharmacology, and Toxicology

, ? Bacteriological examination of some diluted disinfectants routinely used in the Specialist Hospital Yola , Nigeria,? African Journal of Pharmacy and Pharmacology , vol. 3 , no. 5 , pp. 185 - 190 , 2009 . [80] N

Pristimerin protects against doxorubicin-induced cardiotoxicity and fibrosis through modulation of Nrf2 and MAPK/NF-kB signaling pathways

Nishat Ahmed,1 Mohamed A Elkablawy,4,5 Ahmed A Shaaban,2,6 Hany M Abo-Haded3,7 1Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Al-Madinah Al-Munawwarah 30001, Saudi ... Pharmacology, Faculty of Pharmacy, Aqaba University of Technology, Aqaba 77110, Jordan; 7Pediatric Cardiology Unit, Department of Pediatrics, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt

Pharmacology of natural radioprotectors

VP, Vasudev V, Pugalendi KV (2005) Radioprotective effect of sesamol on gamma-radiation induced DNA damage, lipid peroxidation and antioxidants levels in cultured human lymphocytes. Toxicology 209:225 ... damages in cultured human lymphocytes. Toxicology 262:43–49PubMedCrossRefGoogle Scholar Stelzer KJ, Koh WJ, Kurtz H, Greer BE, Griffin TW (1994) Caffeine consumption is associated with decreased severe

Situación de las intoxicaciones en Navarra

We briefly comment on the state of clinical toxicology in Navarra and in the rest of Spain, with reference to the Toxicology Committee of Navarra and its aims. Epidemiological data from the Emergency

Urbanization, environment and pharmaceuticals: advancing comparative physiology, pharmacology and toxicology

assays originally developed to address historical chemical stressors. Because pharmacology and toxicology information is more readily available for these contaminants of emerging concern than other ... immediately clear how useful pre-clinical pharmacology and toxicology information could be to assist ecologically focused efforts. Therapeutics had long been used (e.g. as positive controls) during basic and

Tintas anti-incrustantes de terceira geração: novos biocidas no ambiente aquático

. Additionally, information about physic-chemical properties, environmental levels, toxicology and analytical methods was discussed for the 16 "new" booster biocides used as third-generation antifouling paints ... , Y.; Anal. Chim. Acta 2002, 456, 303.         [ Links ] 66. Cereser, C.; Boget, S.; Parvaz, P.; Revol, A.; Toxicology 2001, 162, 89.         [ Links ] 67. Samanidou, V.; Fytianos, K.; Pfister, G

The human side of automation: experience in clinical pharmacology

environment, clinical pharmacology is the customer of preclinical development in pharmacology, toxicology, drug metabolism and pharmaceutics. We work with drug discovery and preclinical development to provide a ... clinical pharmacology department is quite different fiom this. In an environment where workload and complexity increase progressively in the face of a fixed human and financial resource, seeking efficiency

Making Sense of Pharmacology: Inverse Agonism and Functional Selectivity

Constitutive receptor activity/inverse agonism and functional selectivity/biased agonism are 2 concepts in contemporary pharmacology that have major implications for the use of drugs in medicine and ... considered when drugs are used as medicines or as research tools. constitutive receptor activity, inverse agonism, functional selectivity, biased agonism, pharmacology, G protein coupled receptor

DEVELOPMENT AND VALIDATION OF A SOLID-PHASE EXTRACTION GAS CHROMATOGRAPHY-MASS SPECTROMETRY METHOD FOR THE SIMULTANEOUS QUANTIFICATION OF OPIOID DRUGS IN HUMAN WHOLE BLOOD AND PLASMA

toxicology. ... specificity required in forensic and clinical toxicology. Keywords: Opiods, gas chromatography, mass selective detector, solid-phase extraction. INTRODUCTION Abuse of illicit drugs has incalculable

The human side of automation: experience in clinical pharmacology

environment, clinical pharmacology is the customer of preclinical development in pharmacology, toxicology, drug metabolism and pharmaceutics. We work with drug discovery and preclinical development to provide a ... clinical pharmacology department is quite different fiom this. In an environment where workload and complexity increase progressively in the face of a fixed human and financial resource, seeking efficiency

Behavioral Toxicology: To Toxicants Alter Behavior?

The toxicology section of the Iowa Veterinary Diagnostic Laboratory was started in 1965. The Veterinary Toxicology group has a staff of 6 veterinarians and 4 chemists. Three of the veterinary ... Stimulation . , Psychological Reports . 24 ( 1969 ): 502 . 12. Weiss . Bernard and Laties, Victor. Sehavioral Pharmacology and Toxicology. Annual Review of Pharmacology , 9 , ( 1969 ): 297 - 326 . 2. Testing

Veterinary Toxicology - To Make a Diagnosis

Veterinary Toxicology is rapidly becoming recognized as a distinct discipline in veterinary medicine for several reasons. The use of chemicals for agricultural and household purposes has steadily ... are difficult to differentiate from toxicities. The time has come for veterinary medi­ cine to recognize toxicology as a specia­ lized discipline rather than a branch of physiology or pharmacology

Renal Aspects of Peptic Ulcer Pharmacology

undergoes ex tremely rnpid dc -cstcrificmion to the hiulog1cally active metabol ite, 1111~0proswl ,1cid, priur to or during ah~orpRenal aspects of peptic ulcer pharmacology t ion. No LrnchangL·d d rug 1s

OF REDUCTIONISM AND THE PENDULUM SWING: CONNECTING TOXICOLOGY AND HUMAN HEALTH

In this contribution we will show that research in the field of toxicology, pharmacolo- gy and physiology is by and large characterised by a pendulum swing of which the amplitudes represent risks and ... attempts to robustly connect toxicological research and the potential to improve upon human health with the aid of its results. What will be shown is that research in toxicology, pharmacology and physiology

Kutkins: A Review of Chemistry and Pharmacology

effect. A colorimetric method has been developed for the analysis of the total iridoid content of the rhizomes of Picrorhiza Kurrooa in terms of catalpol. Pharmacology: Some herbalists have described ... vitro study . Division of Pharmacology , Central Drug Research Institute, Lucknow, UP , India. J Pharmacol Toxicol Methods . Oct; 40 ( 3 ): 173 - 9 . 13. Weinges K , Kloss P , Henkels WD . ( 1972