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Athletes with channelopathy may be eligible to play

The European and Bethesda recommendations roughly state that any athlete with channelopathy is not eligible to participate in sports on a presumed risk of potentially life-threatening ventricular tachycardia or fibrillation. However, eligibility decision-making on a presumed risk of ventricular tachycardia or fibrillation is debatable. Channelopathies are primary electrical...

The Netherlands Arrhythmogenic Cardiomyopathy Registry: design and status update

BackgroundClinical research on arrhythmogenic cardiomyopathy (ACM) is typically limited by small patient numbers, retrospective study designs, and inconsistent definitions.AimTo create a large national ACM patient cohort with a vast amount of uniformly collected high-quality data that is readily available for future research.MethodsThis is a multicentre, longitudinal...

Outpatient treatment with the wearable cardioverter defibrillator: clinical experience in two Dutch centres

Introduction The latest European Society of Cardiology Guidelines recommend consideration of a wearable cardioverter-defibrillator (WCD) for patients with a poor left ventricular ejection fraction (LVEF) who are at risk of sudden arrhythmic death but are not eligible for an implantable defibrillator. For these patients a WCD can be an alternative to long-term hospitalisation...

Think twice before you tell

A. A. M. Wilde 0 ) Academic Medical Centre Amsterdam , Amsterdam, the Netherlands 1. van der Zwaag PA, van Rijsingen IA, de Ruiter R, et al. Recurrent and founder mutations in the Netherlands

Think twice before you tell

A. A. M. Wilde Rhythm puzzle - question 0 ) Academic Medical Centre Amsterdam , Amsterdam, the Netherlands - A 34-year-old female comes to your outpatient clinic because of her family history. Her

A common arrhythmia, not so common at an old age

A. A. M. Wilde 0 ) Academic Medical Centre , Amsterdam, Netherlands Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use

Palpitations in a 19-year old man and a slow heart rate at rest

A. A. M. Wilde 0 ) Department of Cardiology, Academic Medical Center , Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands A 19-year-old young man presents in your outpatient clinic brother

Palpitations in a 19-year old man and a slow heart rate at rest

A. A. M. Wilde Answer to rhythm puzzle - This is clearly an abnormal ECG for a 19-year-old man. Initially there is sinus rhythm with a rate that is slightly under 60 beats/min. With 210 msec the PQ

An atypical arrhythmia

A. A. M. Wilde 0 ) Cardioloog AMC Amsterdam, Department of Cardiology, Academic Medical Centre , Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands - You will find the answer elsewhere in this

An atypical arrhythmia

A. A. M. Wilde Answer to rhythm puzzle 0 ) Department of Cardiology, Academic Medical Centre , Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands - There is a narrow complex tachycardia with a

Should you be worried?

J. Elias 0 A. R. Willems 0 A. A. M. Wilde 0 0 A. A. M. Wilde Academical Medical centre Amsterdam , Meibergdreef 9, Postbus 22660, 1100 DD Amsterdam, the Netherlands common in males than females

Dutch outcome in implantable cardioverter-defibrillator therapy (DO-IT): registry design and baseline characteristics of a prospective observational cohort study to predict appropriate indication for implantable cardioverter-defibrillator

BackgroundImplantable cardioverter-defibrillators (ICDs) are widely used for the prevention of sudden cardiac death. At present, both clinical benefit and cost-effectiveness of ICD therapy in primary prevention patients are topics of discussion, as only a minority of these patients will eventually receive appropriate ICD therapy.Methods/designThe DO-IT Registry is a nationwide...

One more time: bibliometric analysis of scientific output remains complicated

T. Opthof 0 A. A. M. Wilde 0 0 T. Opthof Department of Medical Physiology, University Medical Center Utrecht , Utrecht, the Netherlands - Dear Sir, In the May issue of the Netherlands Heart

Bibliometric data in clinical cardiology revisited. The case of 37 Dutch professors

T. Opthof 0 A. A. M. Wilde 0 0 T. Opthof Department of Medical Physiology, University Medical Center Utrecht , Utrecht, the Netherlands In this paper, we assess the bibliometric parameters of 37

Genetic predisposition for sudden cardiac death in myocardial ischaemia: the Arrhythmia Genetics in the NEtherlandS study

Sudden cardiac death from ventricular fibrillation during myocardial infarction is a leading cause of total and cardiovascular mortality. This multifactorial, complex condition clusters in families, suggesting a substantial genetic cause. We carried out a genomewide association study (GWAS) for sudden cardiac death, in the AGNES (Arrhythmia Genetics in the Netherlands) population...

The sense and nonsense of direct-to-consumer genetic testing for cardiovascular disease

, the Netherlands 1 A. A. M. Wilde Department of Cardiology, Academic Medical Center, University of Amsterdam , Amsterdam, the Netherlands 2 A. C. J. W. Janssens ( 3 ) Department of Epidemiology, Erasmus

Founder mutations in the Netherlands: familial idiopathic ventricular fibrillation and DPP6

In this part of a series on founder mutations in the Netherlands, we review familial idiopathic ventricular fibrillation linked to the DPP6 gene. Familial idiopathic ventricular fibrillation determines an intriguing subset of the inheritable arrhythmia syndromes as there is no recognisable phenotype during cardiological investigation other than ventricular arrhythmias highly...

The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium

. J. Aanhaanen B. P. Scicluna C. Annink M. J. B. van den Hoff A. A. M. Wilde M. W. Veldkamp J. M. T. de Bakker V. M. Christoffels C. R. Bezzina Heart Failure Research Center, Academic Medical Center