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Search: authors:"A. C. J. W. Janssens"

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The sense and nonsense of direct-to-consumer genetic testing for cardiovascular disease

, the Netherlands 1 A. A. M. Wilde Department of Cardiology, Academic Medical Center, University of Amsterdam , Amsterdam, the Netherlands 2 A. C. J. W. Janssens ( 3 ) Department of Epidemiology, Erasmus

Pregnancy in multiple sclerosis: clinical and self-report scales

Relapse rate is decreased during pregnancy in multiple sclerosis (MS). Risk for postpartum relapse is increased in the first 3 months after delivery. We aimed to study clinical course of MS around pregnancy, using clinical as well as self-report scales, including data on quality of life (QoL), and to identify clinical factors predisposing for postpartum relapse. We performed a...

Value of EUS in Determining Curative Resectability in Reference to CT and FDG-PET: The Optimal Sequence in Preoperative Staging of Esophageal Cancer?

Background The separate value of endoscopic ultrasonography (EUS), multidetector computed tomography (CT), and 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in the optimal sequence in staging esophageal cancer has not been investigated adequately. Methods The staging records of 216 consecutive operable patients with esophageal cancer were reviewed blindly...

Meta-analyses of genetic studies on major depressive disorder

The genetic basis of major depressive disorder (MDD) has been investigated extensively, but the identification of MDD genes has been hampered by conflicting results from underpowered studies. We review all MDD case–control genetic association studies published before June 2007 and perform meta-analyses for polymorphisms that had been investigated in at least three studies. The...

Insulin-resistance and metabolic syndrome are related to executive function in women in a large family-based study

TMT Trail Making Test 4 K. W. van Dijk Department of Internal Medicine, Leiden University Medical Center , postal zone S-04-P, PO Box 9600, 2300 RC Leiden, The Netherlands 5 A. C. J. W. Janssens J. C. M

Fatigue: an important feature of late-onset Pompe disease

Objective To investigate the prevalence and severity of fatigue in adult patients with Pompe disease. Methods The Fatigue Severity Scale (FSS) was assessed in an international population of 225 adults with Pompe disease, a metabolic disorder presenting as a slowly progressive proximal myopathy. The FSS scores were compared to those of healthy controls and the relationship between...

Genetic risk profiles for depression and anxiety in adult and elderly cohorts

Oostra, H Tiemeier, A C J W Janssens & C M van DuijnDepartment of Psychiatry, VU University Medical Center, Amsterdam, The NetherlandsB W J H Penninx & R van DyckGenetic Epidemiology Unit, Queensland ... Tiemeier in:Nature Research journals • PubMed • Google ScholarSearch for A C J W Janssens in:Nature Research journals • PubMed • Google ScholarSearch for D I Boomsma in:Nature Research journals • PubMed

The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data

The relationship between major depressive disorder (MDD) and bipolar disorder (BD) remains controversial. Previous research has reported differences and similarities in risk factors for MDD and BD, such as predisposing personality traits. For example, high neuroticism is related to both disorders, whereas openness to experience is specific for BD. This study examined the genetic...