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Improved Patient Outcomes by Normalizing Sympathovagal Balance: Differentiating Syncope—Precise Subtype Differentiation Leads to Improved Outcomes

Syncope is difficult to definitively diagnose, even with tilt-table testing and beat-to-beat blood pressure measurements, the gold-standard. Both are qualitative, subjective assessments. There are subtypes of syncope associated with autonomic conditions for which tilt-table testing is not useful. Heart rate variability analyses also include too much ambiguity. Three subtypes of...

Improved Patient Outcomes by Normalizing Sympathovagal Balance: Differentiating Syncope—Precise Subtype Differentiation Leads to Improved Outcomes

Yayac,1 John Oh,1 Mushfiqur Siddique,1 Cesar Acosta,1 Jeysel M. Pinales,1 Aaron I. Vinik,2 and Heather L. Bloom3 1Department of Clinical Medicine, Hahnemann Hospital, Drexel University College of

Improved Patient Outcomes by Normalizing Sympathovagal Balance: Differentiating Syncope—Precise Subtype Differentiation Leads to Improved Outcomes

Syncope is difficult to definitively diagnose, even with tilt-table testing and beat-to-beat blood pressure measurements, the gold-standard. Both are qualitative, subjective assessments. There are subtypes of syncope associated with autonomic conditions for which tilt-table testing is not useful. Heart rate variability analyses also include too much ambiguity. Three subtypes of...

A Comparison of Screening Tools for the Early Detection of Peripheral Neuropathy in Adults with and without Type 2 Diabetes

Objective. Examine the effectiveness of the 128 Hz tuning fork, two monofilaments, and Norfolk Quality of Life Diabetic Neuropathy (QOL-DN) questionnaire as tools for the early detection of diabetic peripheral neuropathy (DPN) in overweight, obese, and inactive (OOI) adults or those who have prediabetes (PD) or type 2 diabetes (T2D). Research Design and Methods. Thirty-four...

A Comparison of Screening Tools for the Early Detection of Peripheral Neuropathy in Adults with and without Type 2 Diabetes

. Vinik,3 and Sheri R. Colberg2 1Elizabeth City State University, Elizabeth City, NC, USA 2Old Dominion University, Norfolk, VA, USA 3Eastern Virginia Medical School, Norfolk, VA, USA Correspondence

Delay between Onset of Symptoms and Seeking Physician Intervention Increases Risk of Diabetic Foot Complications: Results of a Cross-Sectional Population-Based Survey

. Veresiu,2 Etta J. Vinik,3 Aaron I. Vinik,4 Bogdan Florea,5 and Cosmina I. Bondor6 1Society of Diabetic Neuropathy, Worwag Pharma GmbH&Co.KG, Romanian Representative Office, 11 Fagului Street, 400483 Cluj ... educational programs on diabetes and its chronic complications. Competing Interests Etta J. Vinik and Aaron I. Vinik have a patent copyright of the Norfolk QOL-DN. Eastern Virginia Medical School engaged in a

Delay between Onset of Symptoms and Seeking Physician Intervention Increases Risk of Diabetic Foot Complications: Results of a Cross-Sectional Population-Based Survey

and Aaron I. Vinik have a patent copyright of the Norfolk QOL-DN. Eastern Virginia Medical School engaged in a licensing agreement with Worwag; royalties were paid to Eastern Virginia Medical School ... which compensated Etta J. Vinik and Aaron I. Vinik. Cosmina I. Bondor reports nonfinancial support from Worwag Pharma GmbH&Co.KG, Romanian Rep. Office, during the conduct of the study. Ioan A. Veresiu

Bariatric Surgery Restores Cardiac and Sudomotor Autonomic C-Fiber Dysfunction towards Normal in Obese Subjects with Type 2 Diabetes

Objective The aim was to evaluate the impact of bariatric surgery on cardiac and sudomotor autonomic C-fiber function in obese subjects with and without Type 2 diabetes mellitus (T2DM), using sudorimetry and heart rate variability (HRV) analysis. Method Patients were evaluated at baseline, 4, 12 and 24 weeks after vertical sleeve gastrectomy or Roux-en-Y gastric bypass. All...

Capsaicin 8% patch repeat treatment plus standard of care (SOC) versus SOC alone in painful diabetic peripheral neuropathy: a randomised, 52-week, open-label, safety study

Aaron I. Vinik 0 Serge Perrot Etta J. Vinik 0 Ladislav Pazdera Hélène Jacobs Malcolm Stoker Stephen K. Long Robert J. Snijder Marjolijne van der Stoep Enrique Ortega Nathaniel Katz 0 Eastern Virginia

Guidelines in the management of diabetic nerve pain clinical utility of pregabalin

Guidelines in the management of diabetic nerve pain clinical utility of pregabalin Aaron I Vinik, Carolina M Casellini Strelitz Diabetes Center for Endocrine and Metabolic Disorders, Eastern Virginia

Role of Peroxynitrite in the Development of Diabetic Peripheral Neuropathy

Aaron I. Vinik 2 0 Department of Medicine, University of Iowa, and Veterans Affairs Medical Center , Iowa City, IA 1 Pennington Biomedical Research Center, Louisiana State University System , Baton Rouge

A Randomized Withdrawal, Placebo-Controlled Study Evaluating the Efficacy and Tolerability of Tapentadol Extended Release in Patients With Chronic Painful Diabetic Peripheral Neuropathy

OBJECTIVE This study evaluated the efficacy and tolerability of tapentadol extended release (ER) for the management of chronic pain associated with diabetic peripheral neuropathy (DPN).

Barely Scratching the Surface

function in diabetes. AARON I. VINIK, MD, PHD, FCP, MACP Acknowledgments No potential conflicts of interest relevant to this article were reported. Barely scratching the surface

A Pooled Analysis Evaluating the Efficacy and Tolerability of Tapentadol Extended Release for Chronic, Painful Diabetic Peripheral Neuropathy

Background and ObjectiveData from two similarly designed studies of tapentadol extended release (ER) for managing neuropathic pain associated with diabetic peripheral neuropathy (DPN; NCT00455520, NCT01041859) in adults were pooled for this analysis, allowing a detailed evaluation of efficacy in patient subgroups and secondary endpoints.MethodsIn each study, patients were...

Cardiac Autonomic Imbalance in Newly Diagnosed and Established Diabetes Is Associated with Markers of Adipose Tissue Inflammation

Introduction. Diabetics die from cardiovascular disease at a much greater rate than nondiabetics. Cardiac autonomic imbalance predicts increased cardiovascular risk and mortality. We studied the relationship between cardiac autonomic imbalance and adipose tissue-derived inflammation in newly diagnosed and established type 2 diabetes. Materials and Methods. Non-diabetics, newly...

Cardiac Autonomic Imbalance in Newly Diagnosed and Established Diabetes Is Associated with Markers of Adipose Tissue Inflammation

Introduction. Diabetics die from cardiovascular disease at a much greater rate than nondiabetics. Cardiac autonomic imbalance predicts increased cardiovascular risk and mortality. We studied the relationship between cardiac autonomic imbalance and adipose tissue-derived inflammation in newly diagnosed and established type 2 diabetes. Materials and Methods. Non-diabetics, newly...

Cardiac Autonomic Imbalance in Newly Diagnosed and Established Diabetes Is Associated with Markers of Adipose Tissue Inflammation

Introduction. Diabetics die from cardiovascular disease at a much greater rate than nondiabetics. Cardiac autonomic imbalance predicts increased cardiovascular risk and mortality. We studied the relationship between cardiac autonomic imbalance and adipose tissue-derived inflammation in newly diagnosed and established type 2 diabetes. Materials and Methods. Non-diabetics, newly...

Neuropathy: The Crystal Ball for Cardiovascular Disease?

examination of heart rate variability and heart rate using electrocardiogram strips and a history of peripheral neuropathy to predict major adverse cardiovascular events remains to be studied. AARON I. VINIK

A 41-year-old man with polyarthritis and severe autonomic neuropathy

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