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The IL-23p19/EBI3 heterodimeric cytokine termed IL-39 remains a theoretical cytokine in man

ObjectiveThe heterodimeric IL-12 family member cytokines including, IL-12, IL-23, IL-27, and IL-35 and have multiple roles in regulating innate and adaptive immunity with crucial functions in inflammatory disorders such as psoriasis. Chain pairing promiscuity is a feature of the IL-12 family. Recently, based on murine data, a new family member, IL-39, was proposed, consisting of...

Enthesitis: Much More Than Focal Insertion Point Inflammation

Purpose of ReviewRecognition of the importance of enthesitis as the pivotal pathological process underpinning spondyloarthropathies (SpA) has increased in recent years. Thus, we summarized the current knowledge on the pathogenic role of enthesitis on SpA shown by both animal models and human studies in vivo.Recent FindingsExperimental models have shown several SpA-like diseases...

Public reaction to Chikungunya outbreaks in Italy—Insights from an extensive novel data streams-based structural equation modeling analysis

Contributions Conceptualization: Naim Mahroum, Mohammad Adawi, Abdulla Watad. Data curation: Kassem Sharif, Nicola Luigi Bragazzi. Methodology: Roy Waknin, Nicola Luigi Bragazzi. Resources: Bishara Bisharat ... , Arsalan Abu-Much. Supervision: Mohammad Adawi, Howard Amital. Validation: Hussein Mahagna, Bishara Bisharat, Mahmud Mahamid, Arsalan Abu-Much, Abdulla Watad. Writing ? original draft: Naim Mahroum, Roy