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Search: authors:"Akihiko Koyama"

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Potential distribution of Tridentiger barbatus (Günther 1861) and Tridentiger nudicervicus (Tomiyama 1934) in the Seto Inland Sea, western Japan

We developed distribution models for two near-threatened gobiid fishes, Tridentiger barbatus and Tridentiger nudicervicus, based on distribution data and geographic variables in the Ariake Sea, the Yatsushiro Sea, and Suonada Bay. Subsequently, we estimated the potential distribution of both species across all areas of the Seto Inland Sea based on the model predictions. The...

Tau Reduction Does Not Prevent Motor Deficits in Two Mouse Models of Parkinson's Disease

Many neurodegenerative diseases are increasing in prevalence and cannot be prevented or cured. If they shared common pathogenic mechanisms, treatments targeting such mechanisms might be of benefit in multiple conditions. The tau protein has been implicated in the pathogenesis of diverse neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD...

Human P301L-Mutant Tau Expression in Mouse Entorhinal-Hippocampal Network Causes Tau Aggregation and Presynaptic Pathology but No Cognitive Deficits

were similar to those observed in NTG controls (Fig. S2). Scale bar: 500 mm. (PNG) Julie Harris is currently at the Allen Institute for Brain Science, Seattle, WA. Akihiko Koyama is currently at Eisai

A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in α-synuclein transgenic C. elegans

Mutations or multiplications in α-synuclein gene cause familial forms of Parkinson disease or dementia with Lewy bodies (LB), and the deposition of wild-type α-synuclein as LB occurs as a hallmark lesion of these disorders, collectively referred to as synucleinopathies, implicating α-synuclein in the pathogenesis of synucleinopathy. To identify modifier genes of α-synuclein...