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Associations between diabetes mellitus and pulmonary hypertension in chronic respiratory disease patients

patients. Author Contributions Conceptualization: Akiomi Yoshihisa, Koichi Sugimoto. Data curation: Tomoko Takahashi, Akiomi Yoshihisa, Koichi Sugimoto. Formal analysis: Akiomi Yoshihisa, Koichi Sugimoto ... . Investigation: Tomoko Takahashi, Koichi Sugimoto. Methodology: Akiomi Yoshihisa. Project administration: Yasuchika Takeishi. Supervision: Kazuhiko Nakazato, Takafumi Ishida, Yasuchika Takeishi. Validation

Autoimmune disease mouse model exhibits pulmonary arterial hypertension

information S1 File. NC3Rs ARRIVE guidelines checklist. (PDF) Author Contributions Conceptualization: Koichi Sugimoto, Kazuhiko Nakazato, Akiomi Yoshihisa, Yasuchika Takeishi. Data curation: Koichi ... Sugimoto. Formal analysis: Koichi Sugimoto, Akiomi Yoshihisa. Investigation: Koichi Sugimoto, Akihiko Sato, Satoshi Suzuki, Takeshi Machida. Methodology: Takeshi Machida, Hideharu Sekine. Project

Pulmonary Arterial Capacitance Predicts Cardiac Events in Pulmonary Hypertension Due to Left Heart Disease

Background Although pulmonary hypertension due to left heart disease (LHD-PH) accounts for the largest proportion of pulmonary hypertension, few reports on the epidemiological analysis of LHD-PH exist. Recently, pulmonary arterial capacitance (PAC) has attracted attention as a possible factor of right ventricular afterload along with pulmonary vascular resistance. We therefore...

Familial hypertrophic obstructive cardiomyopathy with the GLA E66Q mutation and zebra body

Background Fabry disease is caused by mutations in the α-galactosidase A (GLA) gene, which is located in X-chromosome coding for the lysosomal enzyme of GLA. Among many gene mutations, E66Q mutation is under discussion for its pathogenicity because there is no clinical report showing pathological evidence of Fabry disease with E66Q mutation. Case presentation A 65-year-old...

Impact of Sleep-Disordered Breathing on Heart Rate Turbulence in Heart Failure Patients

Background Sleep-disordered breathing (SDB) is associated with adverse outcomes in patients with chronic heart failure (CHF). Additionally, heart rate turbulence (HRT) reflects changes in the sinus cycle length of baroreceptor in response to hemodynamic fluctuations after ventricular premature beat. Recent studies have suggested that HRT as a marker of vagal activity has a...

Liver Dysfunction Assessed by Model for End-Stage Liver Disease Excluding INR (MELD-XI) Scoring System Predicts Adverse Prognosis in Heart Failure

Aims Liver dysfunction due to heart failure (HF) is often referred to as cardiac or congestive hepatopathy. The composite Model for End-Stage Liver Disease excluding INR (MELD-XI) is a robust scoring system of liver function, and a high score is associated with poor prognosis in advanced HF patients with a heart transplantation and/or ventricular assist device. However, the...