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Computational modeling of pancreatic cancer patients receiving FOLFIRINOX and gemcitabine-based therapies identifies optimum intervention strategies

data cleaning and Michor laboratory members for discussions. Author Contributions Conceptualization: Kimiyo N. Yamamoto, Akira Nakamura, Franziska Michor. Data curation: Kimiyo N. Yamamoto, Akira ... Nakamura, Angela C. Tramontano, Uri Kartoun, Tetsunosuke Shimizu, Yoshihiro Inoue, Mitsuhiro Asakuma, Kazuhisa Uchiyama, Chin Hur. Formal analysis: Kimiyo N. Yamamoto, Akira Nakamura, Lin L. Liu, Mithat

Evaluation of Dynamic Tumor-tracking Intensity-modulated Radiotherapy for Locally Advanced Pancreatic Cancer

Intensity-modulated radiotherapy (IMRT) is now regarded as an important treatment option for patients with locally advanced pancreatic cancer (LAPC). To reduce the underlying tumor motions and dosimetric errors during IMRT as well as the burden of respiratory management for patients, we started to apply a new treatment platform of the dynamic tumor dynamic tumor-tracking...

Structural basis of L-glucose oxidation by scyllo-inositol dehydrogenase: Implications for a novel enzyme subfamily classification

Nakamura, Shunsuke Yajima. Data curation: Kazuhiro Fukano, Kunio Ozawa, Tetsu Shimizu. Formal analysis: Tetsu Shimizu. Funding acquisition: Akira Nakamura, Shunsuke Yajima. Investigation: Kazuhiro Fukano ... , Kunio Ozawa, Masaya Kokubu, Tetsu Shimizu. Methodology: Kazuhiro Fukano, Tetsu Shimizu, Yasuyuki Sasaki, Akira Nakamura, Shunsuke Yajima. Project administration: Shinsaku Ito, Yasuyuki Sasaki, Akira

Studies on the regulatory mechanism of isocitrate dehydrogenase 2 using acetylation mimics

Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, JapanYuqun Xu, Lingwen Liu, Akira Nakamura, Takuya Miyakawa & Masaru TanokuraDepartments of Aging and Geriatric Research, University of Florida, Gainesville ... • Google Scholar Search for Akira Nakamura in:Nature Research journals • PubMed • Google Scholar Search for Shinichi Someya in:Nature Research journals • PubMed • Google Scholar Search for Takuya Miyakawa

Clinical features of IgG4-related periaortitis/periarteritis based on the analysis of 179 patients with IgG4-related disease: a case–control study

Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized systemic condition characterized by high serum immunoglobulin G4 (IgG4) concentration and IgG4-bearing plasma cell infiltration in affected organs. Although it has become evident that IgG4-RD also involves the systemic aortic/arterial system, the precise details of this condition remain unclear. The present study...

The evolutionally-conserved function of group B1 Sox family members confers the unique role of Sox2 in mouse ES cells

Background In mouse ES cells, the function of Sox2 is essential for the maintenance of pluripotency. Since the Sox-family of transcription factors are well conserved in the animal kingdom, addressing the evolutionary origin of Sox2 function in pluripotent stem cells is intriguing from the perspective of understanding the origin of pluripotency. Results Here we approach this...

Atraumatic Occult Odontoid Fracture in Patients with Osteoporosis-Associated Thoracic Kyphotic Deformity: Report of a Case and Review of the Literature

Anderson type II odontoid fractures are reported to be the most common injury of the odontoid process in patients over the age of 65. However, atraumatic occult Anderson type III odontoid fractures have been rarely described and remain a diagnostic challenge. In the present report, we illustrate a 78-year-old female with osteoporosis-associated marked thoracic kyphotic deformity...

Atraumatic Occult Odontoid Fracture in Patients with Osteoporosis-Associated Thoracic Kyphotic Deformity: Report of a Case and Review of the Literature

Anderson type II odontoid fractures are reported to be the most common injury of the odontoid process in patients over the age of 65. However, atraumatic occult Anderson type III odontoid fractures have been rarely described and remain a diagnostic challenge. In the present report, we illustrate a 78-year-old female with osteoporosis-associated marked thoracic kyphotic deformity...

TLR signals posttranscriptionally regulate the cytokine trafficking mediator sortilin

Haifeng Shi Caroline C. Philpott Akira Nakamura OPEN Regulating the transcription, translation and secretion of cytokines is crucial for controlling the appropriate balance of inflammation. Here we report

Region-Specific Activation of oskar mRNA Translation by Inhibition of Bruno-Mediated Repression

A complex program of translational repression, mRNA localization, and translational activation ensures that Oskar (Osk) protein accumulates only at the posterior pole of the Drosophila oocyte. Inappropriate expression of Osk disrupts embryonic axial patterning, and is lethal. A key factor in translational repression is Bruno (Bru), which binds to regulatory elements in the osk...

Dichotomy in Fc?RIIB deficiency and autoimmune-prone SLAM haplotype clarifies the roles of the Fc receptor in development of autoantibodies and glomerulonephritis

Background The significance of a unique inhibitory Fc receptor for IgG, Fc?RIIB (RIIB), in the prevention of spontaneous production of autoantibodies remains controversial, due mainly to the fact that the RIIB locus is adjacent to the autoimmune-related SLAM locus harboring the genes coding for signaling lymphocyte activation molecules, making it difficult to isolate the effect...

Interest in dietary pattern, social capital, and psychological distress: a cross-sectional study in a rural Japanese community

Background Among life-style factors affecting mental health, dietary habits are becoming a public health concern in their relation to psychological distress and social capital. We examined associations between interest in dietary pattern, social capital, and psychological distress with a population-based cross-sectional study in rural Japan. Methods A total of 16,996 residents of...

The Nutrient-Responsive Hormone CCHamide-2 Controls Growth by Regulating Insulin-like Peptides in the Brain of Drosophila melanogaster

The coordination of growth with nutritional status is essential for proper development and physiology. Nutritional information is mostly perceived by peripheral organs before being relayed to the brain, which modulates physiological responses. Hormonal signaling ensures this organ-to-organ communication, and the failure of endocrine regulation in humans can cause diseases...

Secretory leukocyte protease inhibitor modulates urethane-induced lung carcinogenesis

Secretory leukocyte protease inhibitor (SLPI), 11.7 kDa serine protease inhibitor, is produced primarily in the respiratory tract, but it is often elevated in lung, head/neck and ovarian cancers. SLPI expression in relation to cancer progression, metastasis and invasion has been studied extensively in non-small cell lung cancer. However, the role of SLPI during the early stages...

Ci-Pem-1 localizes to the nucleus and represses somatic gene transcription in the germline of Ciona intestinalis embryos

Maki Shirae-Kurabayashi 0 Kazuki Matsuda 0 Akira Nakamura ) 0 0 Laboratory for Germline Development, RIKEN Center for Developmental Biology , Kobe, Hyogo 650-0047 , Japan SUMMARY In many animal

The impact of abdominal compression on outcome in patients treated with stereotactic body radiotherapy for primary lung cancer

Wambaka Ange MAMPUYA Yukinori MATSUO Nami UEKI Mitsuhiro NAKAMURA Nobutaka MUKUMOTO Akira NAKAMURA Yusuke IIZUKA Takahiro KISHI Takashi MIZOWAKI Masahiro HIRAOKA The aim of this study was to

Less is more: specification of the germline by transcriptional repression

Akira Nakamura Geraldine Seydoux In animals, the germline is the only lineage that transmits genetic information to the next generation. Although the founder cells of this lineage are specified