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39 papers found.
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Severe metabolic acidosis after out-of-hospital cardiac arrest: risk factors and association with outcome

BackgroundMetabolic acidosis is frequently observed as a consequence of global ischemia–reperfusion after out-of-hospital cardiac arrest (OHCA). We aimed to identify risk factors and assess the impact of metabolic acidosis on outcome after OHCA.MethodsWe included all consecutive OHCA patients admitted between 2007 and 2012. Using admission data, metabolic acidosis was defined by...

Post-resuscitation care: ERC–ESICM guidelines 2015

Jerry P. Nolan Alain Cariou - injury [9]. Clinical data on neurological injury are con- published guidelines on prognostication after cardiac arrest flicting but a recent study of air versus

Hyperoxia toxicity after cardiac arrest: What is the evidence?

This review gives an overview of current knowledge on hyperoxia pathophysiology and examines experimental and human evidence of hyperoxia effects after cardiac arrest. Oxygen plays a pivotal role in critical care management as a lifesaving therapy through the compensation of the imbalance between oxygen requirements and supply. However, growing evidence sustains the hypothesis of...

The rate of brain death and organ donation in patients resuscitated from cardiac arrest: a systematic review and meta-analysis

Background The occurrence of brain death in patients with hypoxic-ischaemic brain injury after resuscitation from cardiac arrest creates opportunities for organ donation. However, its prevalence is currently unknown. Methods Systematic review. MEDLINE via PubMed, ISI Web of Science and the Cochrane Database of Systematic Reviews were searched for eligible studies (2002–2016). The...

Cold fluids during cardiac arrest: faster cooling but not better outcome!

Alain Cariou Kjetil Sunde - Table 1 Risks and benefits of intra-arrest cooling with cold fluids Maximal protective effects on brain and other tissues Myocardial infarct size reduction (if the cause

Sudden death in ICU: the Finnish experience

Alain Cariou David Bracco Alain Combes - limitations and DNAR (do not attempt resuscitation) in terms of cardiac arrest causes, incidence and outcome. policies, as supported by the proportion of

Therapeutic hypothermia and coronary angiography are mandatory after out-of-hospital cardiac arrest: Yes

Jerry P. Nolan Alain Cariou - Table 1 Coronary artery disease among out-of-hospital cardiac arrest patients with no obvious extra-cardiac cause [2] ST elevation Significant or LBBB CAD

Neuroprotective effect of therapeutic hypothermia versus standard care alone after convulsive status epilepticus: protocol of the multicentre randomised controlled trial HYBERNATUS

Convulsive status epilepticus (CSE) is a major medical emergency associated with a 50 % morbidity rate. CSE guidelines have recommended prompt management for many years, but there is no evidence to date that they have significantly improved practices or outcomes. Developing neuroprotective strategies for use after CSE holds promise for diminishing morbidity and mortality rates...

Association of REL polymorphisms and outcome of patients with septic shock

Background cRel, a subunit of NF-κB, is implicated in the inflammatory response observed in autoimmune disease. Hence, knocked-out mice for cRel had a significantly higher mortality, providing new and important functions of cRel in the physiopathology of septic shock. Whether genetic variants in the human REL gene are associated with severity of septic shock is unknown. Methods...

Brainstem response patterns in deeply-sedated critically-ill patients predict 28-day mortality

: Nicolas Adam, Jeremy Allary, Nora Ait Hamou, Xavier Ambrosi, Marion Antona, Eric Azabou, Omar Ben Hadj Salem, Guillaume Berquier, Francis Bolgert, Alain Cariou, Patrick Chillet, Fabrice ChreÂtien, Vincent

To cool or not to cool non-shockable cardiac arrest patients: it is time for randomized controlled trials

Nicolas Deye Jasmin Arrich Alain Cariou - Table 1 Pros and cons of TH in patients with non-shockable OHCA Pathophysiological arguments: protective effects in asphyxic animal CA models (in terms of

Platelet transfusions in cancer patients with hypoproliferative thrombocytopenia in the intensive care unit

Background Thrombocytopenia is a frequent finding in critically ill cancer patients for whom indications of platelet transfusions are unclear. We herein addressed the current practices in platelet transfusion and the risk of bleeding in cancer patients with hypoproliferative thrombocytopenia in the intensive care unit (ICU). Methods A retrospective monocenter study over a 7-year...

Design and conduct of the activated protein C and corticosteroids for human septic shock (APROCCHSS) trial

Cariou 1 Claude Martin 7 Benoit Misset 6 Alain Renault 5 Blandine Lehmann 4 Valérie Millul 8 Virginie Maxime 0 3 Eric Bellissant 5 0 General ICU, Service de Réanimation, Hôpital Raymond Poincaré

Timing and causes of death in septic shock

BackgroundMost studies about septic shock report a crude mortality rate that neither distinguishes between early and late deaths nor addresses the direct causes of death. We herein aimed to determine the modalities of death in septic shock.MethodsThis was a 6-year (2008–2013) monocenter retrospective study. All consecutive patients diagnosed for septic shock within the first 48 h...