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Systematic evaluation of DNA methylation age estimation with common preprocessing methods and the Infinium MethylationEPIC BeadChip array

BackgroundThe capacity of technologies measuring DNA methylation (DNAm) is rapidly evolving, as are the options for applicable bioinformatics methods. The most commonly used DNAm microarray, the Illumina Infinium HumanMethylation450 (450K array), has recently been replaced by the Illumina Infinium HumanMethylationEPIC (EPIC array), nearly doubling the number of targeted CpG sites...

DNA methylation as a predictor of fetal alcohol spectrum disorder

Background Fetal alcohol spectrum disorder (FASD) is a developmental disorder that manifests through a range of cognitive, adaptive, physiological, and neurobiological deficits resulting from prenatal alcohol exposure. Although the North American prevalence is currently estimated at 2–5%, FASD has proven difficult to identify in the absence of the overt physical features...

Maternal blood contamination of collected cord blood can be identified using DNA methylation at three CpGs

Background Cord blood is a commonly used tissue in environmental, genetic, and epigenetic population studies due to its ready availability and potential to inform on a sensitive period of human development. However, the introduction of maternal blood during labor or cross-contamination during sample collection may complicate downstream analyses. After discovering maternal...

funtooNorm: an R package for normalization of DNA methylation data when there are multiple cell or tissue types

Bouchard 15 16 Antonio Ciampi 14 Ines Colmegna 13 Jean-Philippe Fortin 18 Long Gao 14 Marie-France Hivert 12 17 Marie Hudson 7 11 Michael S. Kobor 5 6 8 Aurelie Labbe 14 l J. M Alexander M. Morin 5 6 Kieran