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Antibodies from a Patient with Type 1 Diabetes and Celiac Disease Bind to Macrophages that Express the Scavenger Receptor CD163

Can J Gastroenterol Antibodies from a patient with type 1 diabetes and celiac disease bind to macrophages that express the scavenger receptor CD163 Brigitte Sonier MSc Alexander Strom Gen-Sheng Wang

Antibodies from a Patient with Type 1 Diabetes and Celiac Disease Bind to Macrophages that Express the Scavenger Receptor CD163

Can J Gastroenterol Antibodies from a patient with type 1 diabetes and celiac disease bind to macrophages that express the scavenger receptor CD163 Brigitte Sonier MSc Alexander Strom Gen-Sheng Wang

Lower serum extracellular superoxide dismutase levels are associated with polyneuropathy in recent-onset diabetes

Increased oxidative stress is implicated in the pathogenesis of experimental diabetic neuropathy, but translational evidence in recent-onset diabetes is scarce. We aimed to determine whether markers of systemic oxidative stress are associated with diabetic sensorimotor polyneuropathy (DSPN) in recent-onset diabetes. In this cross-sectional study, we measured serum concentrations...

Overexpression of cutaneous mitochondrial superoxide dismutase in recent-onset type 2 diabetes

Aims/hypothesis Oxidative stress and microvascular damage have been implicated in the pathogenesis of diabetic neuropathy, with manganese superoxide dismutase 2 (SOD2) responsible for superoxide detoxification in mitochondria. We hypothesised that patients with recently diagnosed type 2 diabetes would show an altered cutaneous expression of SOD2 and endothelial cell area. Methods...

Spatial analysis improves the detection of early corneal nerve fiber loss in patients with recently diagnosed type 2 diabetes

Corneal confocal microscopy (CCM) has revealed reduced corneal nerve fiber (CNF) length and density (CNFL, CNFD) in patients with diabetes, but the spatial pattern of CNF loss has not been studied. We aimed to determine whether spatial analysis of the distribution of corneal nerve branching points (CNBPs) may contribute to improving the detection of early CNF loss. We...

The Kambarata 2 blast-fill dam, Kyrgyz Republic:blast event, geophysical monitoring and dam structure modelling

Almaz Torgoev 0 Alexander Strom Yuan Xu Tomas Fernandez-Steeger 0 Department of Geology, University of Liege , Liege , Belgium Background: The blast- and earth-fill dam of the Kambarata 2 hydropower

Differential Patterns and Determinants of Cardiac Autonomic Nerve Dysfunction during Endotoxemia and Oral Fat Load in Humans

The autonomic nervous system (ANS) plays an important role in regulating the metabolic homeostasis and controlling immune function. ANS alterations can be detected by reduced heart rate variability (HRV) in conditions like diabetes and sepsis. We determined the effects of experimental conditions mimicking inflammation and hyperlipidemia on HRV and heart rate (HR) in relation to...

Foodborne Transmission of Bovine Spongiform Encephalopathy to Non-Human Primates Results in Preclinical Rapid-Onset Obesity

Obesity has become one of the largest public health challenges worldwide. Recently, certain bacterial and viral pathogens have been implicated in the pathogenesis of obesity. In the present study, we retrospectively analyzed clinical data, plasma samples and post-mortem tissue specimens derived from a risk assessment study in bovine spongiform encephalopathy (BSE)-infected female...

Early Detection of Nerve Fiber Loss by Corneal Confocal Microscopy and Skin Biopsy in Recently Diagnosed Type 2 Diabetes

Papanas Andrey Zhivov Stephan Allgeier Karsten Winter Iris Ziegler Jutta Brüggemann Alexander Strom Sabine Peschel Bernd Köhler Oliver Stachs Rudolf F. Guthoff Michael Roden for the German Diabetes Study

Erratum

· Alexander Strom · Fernando Caceres · Eric Pirard

Improved Preservation of Residual Beta Cell Function by Atorvastatin in Patients with Recent Onset Type 1 Diabetes and High CRP Levels (DIATOR Trial)

Background A recent randomized placebo-controlled trial of the effect of atorvastatin treatment on the progression of newly diagnosed type 1 diabetes suggested a slower decline of residual beta cell function with statin treatment. Aim of this secondary analysis was to identify patient subgroups which differ in the decline of beta cell function during treatment with atorvastatin...