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Search: authors:"Alexandra L Brown"

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Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase

information Author notesAmarjit Mishra & Alexandra L. Brown These authors contributed equally to this work Stewart J. Levine & Jay H. Chung These authors jointly supervised this work AffiliationsLaboratory of ... , Bethesda, Maryland 20892, USAXuan Qu & Zu-Xi Yu AuthorsSearch for Amarjit Mishra in:Nature Research journals • PubMed • Google ScholarSearch for Alexandra L. Brown in:Nature Research journals • PubMed

Identification of novel substrates for human checkpoint kinase Chk1 and Chk2 through genome-wide screening using a consensus Chk phosphorylation motif

Checkpoint kinase 1 (Chk1) and Chk2 are effector kinases in the cellular DNA damage response and impairment of their function is closely related to tumorigenesis. Previous studies revealed several substrate proteins of Chk1 and Chk2, but identification of additional targets is still important in order to understand their tumor suppressor functions. In this study, we screened...