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Search: authors:"Alexis A. Kurmis"

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Interference with DNA repair after ionizing radiation by a pyrrole-imidazole polyamide

, Peter B. Dervan, Nicholas G. Nickols. Data curation: Silvia Diaz-Perez, Nathanael Kane, Alexis A. Kurmis, Fei Yang, Nicolas T. Kummer. 9 / 11 Formal analysis: Silvia Diaz-Perez, Alexis A. Kurmis, Fei ... , Nathanael Kane, Alexis A. Kurmis, Fei Yang, Nicholas G. Nickols. Project administration: Nicholas G. Nickols. Resources: Nicholas G. Nickols. Supervision: Peter B. Dervan, Nicholas G. Nickols. Writing

Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide

Pyrrole-imidazole (Py-Im) polyamides are high affinity DNA-binding small molecules that can inhibit protein-DNA interactions. In VCaP cells, a human prostate cancer cell line overexpressing both AR and the TMPRSS2-ERG gene fusion, an androgen response element (ARE)-targeted Py-Im polyamide significantly downregulates AR driven gene expression. Polyamide exposure to VCaP cells...