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62 papers found.
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T cell receptor repertoire among women who cleared and failed to clear cervical human papillomavirus infection: An exploratory proof-of-principle study

Kuhs, Shih-Wen Lin, Xing Hua, Mark Schiffman, Robert D. Burk, Ana Cecilia Rodriguez, Rolando Herrero, Christian C. Abnet, Neal D. Freedman, Ligia A. Pinto, David Hamm, Harlan Robins, Allan Hildesheim ... Robins, Allan Hildesheim, Mahboobeh Safaeian. Methodology: Xing Hua, David Hamm, Harlan Robins, Jianxin Shi. Project administration: Krystle A. Lang Kuhs, Shih-Wen Lin, Mahboobeh Safaeian. Resources: Ana

Epstein-Barr Virus Antibodies and the Risk of Associated Malignancies: Review of the Literature

Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland (Anna E. Coghill, Allan Hildesheim). This research was funded by the intramural program at the

Invited Commentary: Epstein-Barr Virus–Based Screening for the Early Detection of Nasopharyngeal Carcinoma—A New Frontier

Allan Hildesheim 0 0 National Cancer Institute , 6120 Executive Boulevard, Room 7066, Rockville, MD 20852 ( Approximately 2 million new cases of cancer are caused by infections each year. For many ... Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland (Allan Hildesheim). As an employee of the National Cancer Institute, the author is supported by intramural National Cancer Institute

Associations between self-reported diabetes and 78 circulating markers of inflammation, immunity, and metabolism among adults in the United States

, Britton Trabert, Mark P. Purdue, Nicolas Wentzensen, Ruth M. Pfeiffer, Hormuzd A. Katki, Allan Hildesheim, Troy J. Kemp, Ligia A. Pinto, Anil K. Chaturvedi, Mahboobeh Safaeian. Data curation: Alison L. Van ... acquisition: Britton Trabert, Mark P. Purdue, Nicolas Wentzensen, Allan Hildesheim, Troy J. Kemp, Ligia A. Pinto, Anil K. Chaturvedi, Mahboobeh Safaeian. Investigation: Meredith S. Shiels, Britton Trabert, Mark

Partial Least Square Discriminant Analysis Discovered a Dietary Pattern Inversely Associated with Nasopharyngeal Carcinoma Risk

Evidence on the association between dietary component, dietary pattern and nasopharyngeal carcinoma (NPC) is scarce. A major challenge is the high degree of correlation among dietary constituents. We aimed to identify dietary pattern associated with NPC and to illustrate the dose-response relationship between the identified dietary pattern scores and the risk of NPC. Taking...

Invited Commentary: Circulating Inflammation Markers and Cancer Risk—Implications for Epidemiologic Studies

of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland (Anil K. Chaturvedi, Allan Hildesheim); and Nutritional Epidemiology Branch, Division of Cancer Epidemiology and

A prospective study of absolute risk and determinants of human papillomavirus incidence among young women in Costa Rica

(Immunology Technician); at the National Cancer Institute, Bethesda, MD: Nora Macklin (Trial Coordinator), Allan Hildesheim (Coprincipal Investigator and NCI Co-project Officer), Douglas R. Lowy (HPV Virologist

An Updated Natural History Model of Cervical Cancer: Derivation of Model Parameters

Mathematical models of cervical cancer have been widely used to evaluate the comparative effectiveness and cost-effectiveness of preventive strategies. Major advances in the understanding of cervical carcinogenesis motivate the creation of a new disease paradigm in such models. To keep pace with the most recent evidence, we updated a previously developed microsimulation model of...

Performance of Self-Collected Cervical Samples in Screening for Future Precancer Using Human Papillomavirus DNA Testing

Epidemiológico Guanacaste , Fundación INCIENSA, San José, Costa Rica (CP, PG 2 Carolina Porras , Allan Hildesheim, Paula González, Mark Schiffman 3 The Author 2014. Published by Oxford University Press. All

Impact of Human Papillomavirus Vaccination on Cervical Cytology Screening, Colposcopy, and Treatment

of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland (Diane Solomon, Allan Hildesheim, Sholom Wacholder, Mark Schiffman); and Prevention and Implementation Group ... , Maryland—Allan Hildesheim (coPrincipal Investigator and NCI co-Project Officer), Aimée R. Kreimer (investigator), Douglas R. Lowy (HPV virologist), Nora Macklin (trial coordinator), Mark Schiffman (medical

Human Papillomavirus Vaccine Should Be Given before Sexual Debut for Maximum Benefit

Allan Hildesheim 1 Rolando Herrero 0 0 Proyecto Epidemiologico Guanacaste , Fundacion INCIENSA, San Jose , Costa Rica 1 Division of Cancer Epidemiology and Genetics, National Cancer Institute

A large, population-based study of age-related associations between vaginal pH and human papillomavirus infection

Background Vaginal pH is related to genital tract inflammation and changes in the bacterial flora, both suggested cofactors for persistence of human papillomavirus (HPV) infection. To evaluate the relationship between vaginal pH and HPV, we analyzed data from our large population-based study in Guanacaste, Costa Rica. We examined vaginal pH and the risk of HPV infection...

Longitudinal Analysis of Carcinogenic Human Papillomavirus Infection and Associated Cytologic Abnormalities in the Guanacaste Natural History Study: Looking Ahead to Cotesting

Background. Few studies have addressed the timing of cervical cytologic abnormalities and human papillomavirus (HPV) positivity during the course of an infection. It remains largely unknown how infections detected by HPV and cytology wax and wane relative to each other. The aim of this analysis was to assess the longitudinal relationship of abnormal cytology and HPV positivity in...

Clustering of Multiple Human Papillomavirus Infections in Women From a Population-Based Study in Guanacaste, Costa Rica

Objective. To evaluate clustering patterns of prevalent infection with multiple human papillomavirus (HPV) types in 8365 nonhysterectomized women from the Guanacaste Study of HPV Natural History. Methods. HPV testing was performed on cervical cells by MY09/M11 L1 degenerate consensus primer polymerase chain reaction method, with dot-blot hybridization for genotyping. Logistic...

Circulating Inflammation Markers and Prospective Risk for Lung Cancer

Background Despite growing recognition of an etiologic role for inflammation in lung carcinogenesis, few prospective epidemiologic studies have comprehensively investigated the association of circulating inflammation markers with lung cancer.

Reduced Prevalence of Vulvar HPV16/18 Infection Among Women Who Received the HPV16/18 Bivalent Vaccine: A Nested Analysis Within the Costa Rica Vaccine Trial

National Cancer Institute, Bethesda, MD—Allan Hildesheim (coprincipal investigator and National Cancer Institute [NCI] coproject officer), Aimée R. Kreimer (co-investigator), Douglas R. Lowy (HPV virologist ... Kuhs, Mark Schiffman, Douglas Lowy, Mahboobeh Safaeian, John Schiller, Sholom Wacholder, Allan Hildesheim, and Aimée R. Kreimer: GlaxoSmithKline Biologicals (GSK) provided vaccine and support for aspects

Methylation of Human Papillomavirus Type 16 Genome and Risk of Cervical Precancer in a Costa Rican Population

Background Previous studies have suggested an association between human papillomavirus type 16 (HPV16) genome methylation and cervical intraepithelial neoplasia grade 3 (CIN3) (ie, cervical precancer) and cancer, but the results have been inconsistent.

Cigarette Smoking and Variations in Systemic Immune and Inflammation Markers

Background A comprehensive characterization of the effects of cigarette smoke on systemic soluble immune/inflammatory markers may provide insight into the mechanisms through which smoking causes disease.

Long-Term Persistence of Prevalently Detected Human Papillomavirus Infections in the Absence of Detectable Cervical Precancer and Cancer

Background. Detailed descriptions of long-term persistence of human papillomavirus (HPV) in the absence of cervical precancer are lacking. Methods. In a large, population-based natural study conducted in Guanacaste, Costa Rica, we studied a subset of 810 initially HPV-positive women with ≥3 years of active follow-up with ≥3 screening visits who had no future evidence of cervical...