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Search: authors:"Amit N Khachane"

7 papers found.
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Mining Mammalian Transcript Data for Functional Long Non-Coding RNAs

Background The role of long non-coding RNAs (lncRNAs) in controlling gene expression has garnered increased interest in recent years. Sequencing projects, such as Fantom3 for mouse and H-InvDB for human, have generated abundant data on transcribed components of mammalian cells, the majority of which appear not to be protein-coding. However, much of the non-protein-coding...

Strong association between pseudogenization mechanisms and gene sequence length

Pseudogenes arise from the decay of gene copies following either RNA-mediated duplication (processed pseudogenes) or DNA-mediated duplication (nonprocessed pseudogenes). Here, we show that long protein-coding genes tend to produce more nonprocessed pseudogenes than short genes, whereas the opposite is true for processed pseudogenes. Protein-coding genes longer than 3000 bp are 6...

Assessing the genomic evidence for conserved transcribed pseudogenes under selection

Background Transcribed pseudogenes are copies of protein-coding genes that have accumulated indicators of coding-sequence decay (such as frameshifts and premature stop codons), but nonetheless remain transcribed. Recent experimental evidence indicates that transcribed pseudogenes may regulate the expression of homologous genes, through antisense interference, or generation of...

Dynamics of Reductive Genome Evolution in Mitochondria and Obligate Intracellular Microbes

Amit N. Khachane 0 Kenneth N. Timmis 0 Vtor A. P. Martins dos Santos 0 0 Department of Environmental Microbiology, Helmholtz Center for Infection Research , Braunschweig, Germany Reductive evolution

Uracil content of 16S rRNA of thermophilic and psychrophilic prokaryotes correlates inversely with their optimal growth temperatures

Amit N. Khachane 0 Kenneth N. Timmis 0 Vtor A. P. Martins dos Santos 0 0 Division of Microbiology, GBFGerman Research Centre for Biotechnology , Braunschweig, Germany We report here the finding of a

Genome-Wide Pharmacogenomic Study of Neurocognition As an Indicator of Antipsychotic Treatment Response in Schizophrenia

of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USAJoseph L McClay, Daniel E Adkins, Karolina Åberg, Jozsef Bukszár, Amit N Khachane & Edwin J C G van den OordDepartment of ... ScholarSearch for Karolina Åberg in:Nature Research journals • PubMed • Google ScholarSearch for Jozsef Bukszár in:Nature Research journals • PubMed • Google ScholarSearch for Amit N Khachane in:Nature Research

The missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae

Gaigalat 14 Stefanie Herrmann 13 Amit N Khachane 12 Christof Larisch 9 Stefanie Link 7 Burkhard Linke 9 Folker Meyer 1 9 Sascha Mormann 14 Diana Nakunst 14 Christian Rckert 14 Susanne Schneiker