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Performance of Self-Collected Cervical Samples in Screening for Future Precancer Using Human Papillomavirus DNA Testing

Background: Self-collected human papillomavirus (HPV) testing could reduce barriers to cervical cancer screening, with performance comparable to clinician-collected specimens. The ability of self-collected specimens to cross-sectionally and prospectively detect precursor lesions was investigated in an HPV vaccine randomized trial in Costa Rica.

María Cristina García-Sancho y Álvarez-Tostado: Primera neurocirujana en Latinoamérica

Latin America   Gabriela Castañeda López,1 Ana Cecilia Rodríguez de Romo2 *   1 Investigadora asociada en el Laboratorio de Historia de la Medicina del Instituto Nacional de Neurología y ... Medicina, Facultad de Medicina, Universidad Nacional Autónoma de México.   *Correspondencia: Dra. Ana Cecilia Rodríguez de Romo. Laboratorio de Historia de la Medicina. Instituto Nacional de

Impact of Human Papillomavirus Vaccination on Cervical Cytology Screening, Colposcopy, and Treatment

(Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud) Foundation, San José, Costa Rica (Ana Cecilia Rodríguez, Rolando Herrero, Paula González, Carolina Porras, Silvia Jiménez); Division ... ), Lidia Ana Morera (head study nurse), Elmer Pérez (field supervisor), Carolina Porras (coinvestigator), Ana Cecilia Rodríguez (co-Principal Investigator), and Libia Rivas (clinical coordinator); University

¿Reticularismo o neuronismo?: diferente percepción de la misma circunstancia

Rodríguez de Romo   Laboratorio de Historia de la Medicina Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez.   Correspondencia: Ana Cecilia Rodríguez de Romo. Instituto

Long-Term Persistence of Prevalently Detected Human Papillomavirus Infections in the Absence of Detectable Cervical Precancer and Cancer

Background. Detailed descriptions of long-term persistence of human papillomavirus (HPV) in the absence of cervical precancer are lacking. Methods. In a large, population-based natural study conducted in Guanacaste, Costa Rica, we studied a subset of 810 initially HPV-positive women with ≥3 years of active follow-up with ≥3 screening visits who had no future evidence of cervical...

Human Papillomavirus Infection with Multiple Types: Pattern of Coinfection and Risk of Cervical Disease

(See the article by Plummer et al., on pages 891–3.) Objective. We investigated coinfection patterns for 25 human papillomavirus (HPV) types and assessed the risk conferred by multiple HPV types toward cervical disease. Methods. Sexually active women (n=5,871) in the NCI-sponsored Costa Rica HPV Vaccine Trial's prevaccination enrollment visit were analyzed. Genotyping for 25 HPVs...

Longitudinal Study of Human Papillomavirus Persistence and Cervical Intraepithelial Neoplasia Grade 2/3: Critical Role of Duration of Infection

Background The natural history of human papillomavirus (HPV) infections in older women is critical for preventive strategies, including vaccination and screening intervals, but is poorly understood. In a 7-year population-based cohort study in Guanacaste, Costa Rica, we examined whether women’s age and the duration of carcinogenic HPV infections influenced subsequent persistence...

Rapid Clearance of Human Papillomavirus and Implications for Clinical Focus on Persistent Infections

Health professionals and the public need to understand the natural history of human papillomavirus (HPV) infections of the cervix to best use the information provided by new molecular screening tests. We investigated outcomes of 800 carcinogenic HPV infections detected in 599 women at enrollment into a population-based cohort (Guanacaste, Costa Rica). For individual infections...

Determinants of seropositivity among HPV-16/18 DNA positive young women

Background Not all women infected with HPV-16/18 have detectable levels of HPV-16/18 antibodies, those who seroconvert develop low antibody levels, and seroconversion occurs typically several months post-infection. We evaluated determinants of seropositivity among 646 women infected with HPV-16 and/or HPV-18. Methods Data are from the enrollment visit of the NCI-sponsored Costa...

Common Variants in Immune and DNA Repair Genes and Risk for Human Papillomavirus Persistence and Progression to Cervical Cancer

Background. We examined host genetic factors to identify those more common in individuals whose human papillomavirus (HPV) infections were most likely to persist and progress to cervical intraepithelial neoplasia grade 3 (CIN3) and cancer. Methods. We genotyped 92 single-nucleotide polymorphisms (SNPs) from 49 candidate immune response and DNA repair genes obtained from 469 women...